Bismuth-based nanoparticles as radiosensitizer in low and high dose rate brachytherapy

• Autorzy: Rajaee Azimeh , Wang Shi , Zhao Lingyun

Identyfikatory

DOI

10.2478/pjmpe-2019-0011

• Języki publikacji: EN

Abstrakty

EN

Background: Recently bismuth-based nanoparticles have attracted increasing attention as a dose amplification agent in radiation therapy due to high atomic number, high photoelectric absorption, low cost, and low toxicity. Objectives: This study aims to calculate physical aspects of dose enhancement of bismuth-based nanoparticles in the presence of brachytherapy source by Monte Carlo simulation and an analytical method for low mono-energy. Materials and methods: After simulation and validation brachytherapy sources (Iodine-125 and Ytterbium-169) by Monte Carlo code, bismuth-based nanoparticles (bismuth, bismuth oxide, bismuth sulfide, and bismuth ferrite) were modeled in the sizes of 50 nm and 100 nm for two concentrations of 10 and 20 mg/ml. Dose enhancement factors for the bismuth-based nanoparticles were measured at both brachytherapy sources. Furthermore, the dose amplification was calculated with an analytic method at 30 keV mono-energy. Results: Dose enhancement factor was greatest with pure bismuth nanoparticles, followed by bismuth oxide, bismuth sulfide and bismuth ferrite for both radiation source and simulation methods. The dose amplification for the bismuth-based nanoparticles increased with increasing size and concentration of nanoparticles. Conclusion: The physical aspect dose enhancement of the nanoparticles was shown by Monte Carlo and analytic method. The results have proved bismuth-based nanoparticles deserve further study as a radiosensitizer.

Słowa kluczowe

EN

bismuth-based nanoparticles; brachytherapy sources; radiosensitizers; Monte Carlo simulation; dose enhancement

• Wydawca: Polskie Towarzystwo Fizyki Medycznej ; De Gruyter
• Czasopismo: Polish Journal of Medical Physics and Engineering
• Rocznik: 2019
• Tom: Vol. 25, Iss. 2
• Strony: 79--85
• Opis fizyczny: Bibliogr. 27 poz., rys., tab.

Twórcy

autor

Rajaee Azimeh

• Institute of Medical Physics and Engineering, Department of Engineering Physics, Tsinghua University, 100084, Beijing, China

autor

Wang Shi

• Institute of Medical Physics and Engineering, Department of Engineering Physics, Tsinghua University, 100084, Beijing, China

autor

Zhao Lingyun

• State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, 100084, Beijing, China

Bibliografia

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Uwagi

Opracowanie rekordu ze środków MNiSW, umowa Nr 461252 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2020).