Organic bacteriostatic material

• Autorzy: Flak Tomasz , Paluch Jarosław , Gabor Jadwiga , Okła Hubert , Stanula Arkadiusz , Markowski Jarosław , Plich Jan , Swinarew Andrzej S.

Identyfikatory

DOI

10.34821/eng.biomat.155.2020.17-21

• Języki publikacji: EN

Abstrakty

EN

The use of antibiotics to treat bacterial infections is becoming less and less effective year by year due to the increasing resistance of bacteria. The microbial evolutionarily acquired resistance to antibiotics increases the threat to man’s life due to difficulties regarding effective therapies to fight infections. Therefore, apart from treatment, it is necessary to introduce appropriate prophylaxis which limits the multiplication of bacterial colonies on everyday use objects. Due to the antibiotic resistance phenomenon, it is important to find a new material with antibacterial properties for FDM 3D printing in medical applications. The work contains research on a new chemical compound used as an additive to thermoplastics. The rhodamine derivative was synthesized via the 4-diphenylaminobenzaldehyde reaction with 1.3-indendione in a boiling mixture of EtOH/H2SO4. The obtained chemical compound was used as a bacteriostatic modifier of the polycarbonate (PC) properties, as such a modification enables application e.g. for medical device housings or for surfaces frequently touched by people. The modifier and the commercially available polymer were compounded with a high-temperature screw extruder and a filament for FDM 3D printer was created. The modified polymer revealed antibacterial properties relative to Escherichia coli and good thermal stability during the processing.

Słowa kluczowe

EN

bacteriostatic; rhodamine; polymer; Escherichia Coli

• Wydawca: Polish Society for Biomaterials in Cracow
• Czasopismo: Engineering of Biomaterials
• Rocznik: 2020
• Tom: Vol. 23, no. 155
• Strony: 17--21
• Opis fizyczny: Bibliogr. 10 poz., rys., tab.

Twórcy

autor

Flak Tomasz

• Polymertech Ltd. 75 Pułku Piechoty 1, 41-500 Chorzów, Poland
• Faculty of Science and Technology, University of Silesia in Katowice, 75 Pułku Piechoty 1A, 41-500 Chorzów, Poland

autor

Paluch Jarosław

• Department of Laryngology, School of Medicine in Katowice, Medical University of Silesia in Katowice, Poland ul. Medyków 18, 40-752 Katowice, Poland

autor

Gabor Jadwiga

• Faculty of Science and Technology, University of Silesia in Katowice, 75 Pułku Piechoty 1A, 41-500 Chorzów, Poland

autor

Okła Hubert

• Faculty of Science and Technology, University of Silesia in Katowice, 75 Pułku Piechoty 1A, 41-500 Chorzów, Poland

autor

Stanula Arkadiusz

• Department of Individual Sports, Institute of Sport Science, The Jerzy Kukuczka Academy of Physical Education, Mikołowska 72A, 40-065 Katowice, Poland

autor

Markowski Jarosław

• Department of Laryngology, School of Medicine in Katowice, Medical University of Silesia in Katowice, Poland ul. Medyków 18, 40-752 Katowice, Poland

autor

Plich Jan

• Department of Laryngology, School of Medicine in Katowice, Medical University of Silesia in Katowice, Poland ul. Medyków 18, 40-752 Katowice, Poland

autor

Swinarew Andrzej S.

• Faculty of Science and Technology, University of Silesia in Katowice, 75 Pułku Piechoty 1A, 41-500 Chorzów, Poland
• Department of Individual Sports, Institute of Sport Science, The Jerzy Kukuczka Academy of Physical Education, Mikołowska 72A, 40-065 Katowice, Poland

Bibliografia

• [1] Høiby N., Bjarnsholt T., Givskov M., Molin S., Ciofu O.: Antibiotic resistance of bacterial biofilms. Int J Antimicrob Agents 35(4) (2010) 322-332. doi:10.1016/j.ijantimicag.2009.12.011
• [2] Novo A., André S., Viana P., Nunes O.C., Manaia C.M.: Antibiotic resistance, antimicrobial residues and bacterial community composition in urban wastewater. Water Res. 47(5) (2013) 1875-1887. doi:10.1016/j.watres.2013.01.010
• [3] Dafale N.A., Semwal U.P., Rajput R.K., Singh G.N.: Selection of appropriate analytical tools to determine the potency and bioactivity of antibiotics and antibiotic resistance. J Pharm Anal. 6(4) (2016) 207-213. doi:10.1016/j.jpha.2016.05.006
• [4] Bakhsheshi-Rad H.R., Hamzah E., Kasiri-Asgarani M., Saud S.N., Yaghoubidoust F., Akbari E.: Structure, corrosion behavior, and antibacterial properties of nano-silica/graphene oxide coating on biodegradable magnesium alloy for biomedical applications. Vacuum 131 (2016) 106-110.
• [5] Li L., Zhao C., Zhang Y., et al. Effect of stable antimicrobial nanosilver packaging on inhibiting mildew and in storage of rice. Food Chem. 215 (2017) 477-482. doi:10.1016/j.foodchem.2016.08.013
• [6] Scientific Committee on Emerging and Newly Identified Health Risks SCENIHR, Opinion on nanosilver. Safety, health and environmental effects and role in antimicrobial resistance, 10-11 June 2014 r., European Union, 2013 ISSN 1831-4783, ISBN 978-92-79- 30132-2, doi:10.2772/76851 ND-AS-13-002-EN-N.
• [7] Bucki R., Pastore J.J., Randhawa P., Vegners R., Weiner D.J., Janmey P.A.: Antibacterial activities of rhodamine B-conjugated gelsolin-derived peptides compared to those of the antimicrobial peptides cathelicidin LL37, magainin II, and melittin. Antimicrob Agents Chemother. 48(5) (2004) 1526-1533. doi:10.1128/ aac.48.5.1526-1533.2004
• [8] Xiaolei Wu, Hai Shu, Baojing Zhou, Yougliang Geng, Xiaofeng Bao, Jing Zhu: Design and synthesis of a new rhodamine B-based fluorescent probe for selective detection of glutathione and its application for live cell imaging, Sensors and Actuators B: Chemical 237 (2016) 431-442. doi:10.1016/j.snb.2016.06.161.
• [9] Li Yi, Zhang Zhou-Na, Ca Wei, Gao Xiao-Meng, Wang Beng: Mercury ion selective light addressable potentiometric sensor based on PVC membrane. Zhejiang DaxueXuebao (Gongxue Ban)/Journal of Zhejiang University (Engineering Science) 44 (2010) 1231-1236. doi:10.3785/j.issn.1008-973X.2010.06.033.
• [10] ISO 22196:2007(E), Plastics. Measurement of antibacterial activity on plastics surfaces.

Uwagi

Opracowanie rekordu ze środków MNiSW, umowa Nr 461252 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2020).