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Development of the objective method for detection and analysis of disorders in the olfactory event-related potentials

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EN
Abstrakty
EN
This paper presents an objective method for early diagnosis of disorders and diseases of olfactory system. To achieve this goal the author designed a fragrance dosing prototype, which is synchronized with the dedicated recorder of olfactory evoked potentials. Automatic synchronization of registration of olfactory event-related potentials with dosing of stimulus fragrances enables precise determination of latency occurring between stimulation and response of the central nervous system. Obtained results allow to prove that developed prototype enables the evaluation of the olfactory system disorders in the context of neurodegenerative disorders. However it is necessary to establish a standardization procedures, before a wide implementation in a clinical practice. That is why the developed method requires a broader research which is an issue of a much larger group of patients and significantly longer duration of the study.
Twórcy
autor
  • Department of Microelectronics and Computer Science, Lodz University of Technology, Wólczańska 221/223, 90-924 Łódź, Poland
autor
  • Department of Microelectronics and Computer Science, Lodz University of Technology, Wólczańska 221/223, 90-924 Łódź, Poland
Bibliografia
  • [1] Y. Fan, K. Cheung, M.M. Chong, H.D. Chua, K.W. Chow and C.H. Liu. “Computational Fluid Dynamics Analysis on the Upper Airways of Obstructive Sleep Apnea Using Patient-Specific Models”. Intl. Journal of Computer Science. Vol 38, No 4. Advance Online Publication.. Nov. 2011.
  • [2] K.S. Burrowes, A.J. Swan, N.J. Warren and M.H. Tawhai. “Towards a virtual lung: multi-scale, multi-physics modelling of the pulmonary system”. Phyl. Trans. Of The Royal Society A, Vol. 366, pp 3247-3263, July 2008.
  • [3] J.F. Golden, J.W. Clark,Jr. and P.M. Stevens. “Mathematical Modelling of Pulmonary Airway Dynamics”. IEEE Tr. On Biomedical Engineering, Vol. BME-20, No. 6, pp 397-404, Nov. 1973.
  • [4] M.F. Olender, J.W. Clark, Jr. and P.M. Stevens. “Analog Computer Simulation of Maximum Expiratory Flow Limitation”. IEEE Tr. On Biomedical Engineering, Vol. BME-23, No. 6, pp 445-452, Nov. 1976.
  • [5] K.R. Lutchen, F.P. Primiano, Jr. and G.M. Saidel. “A Nonlinear Model Combining Pulmonary Mechanics and Gas Concentration Dynamics”. IEEE Tr. On Biomedical Engineering, Vol. BME-29, No. 9, pp 629-641, Set. 1982.
  • [6] S. Abboud, O. Barnea, A. Guber, N. Narkiss and I. Bruderman. “Maximum expiratory flow-volume curve: mathematical model and experimental results”. Mod. Eng. Phys. Vol. 17, No. 5, pp 332-336, 1995.
  • [7] C.H. Liu, S.C. Niranjan, J.W. Clark, Jr., K.Y. San, J.B. Zwischenberger, and A. Bidani. “Airway mechanics, gas exchange and blood flow in a nonlinear model of the normal human lung”. J. Appl. Physiol., Vol. 84, pp 1447-1469, 1998.
  • [8] A. Athanasiades, F. Ghorbel, J.W. Clark, Jr., S.C. Niranjan, J. Olansen, J.B. Zwischenberger, and A. Bidani. “Energy Analysis of a Nonlinear Model of the Normal Human Lung”. J. of Biological Systems, Vol. 8, No 2, pp 115-139, 2000.
  • [9] A.G. Polak and K.R. Lutchen. “Computational Model for Forced Expiration from Asymmetric Normal Lungs”. Annals of Biomedical Engineering, Vol. 31, pp 891-907, 2003.
  • [10] D.L. Fry and R.E. Hyatt. “A Unified Analysis of the Relationship Between Pressure, Volume and Gasflow in the Lungs of Normal and Diseased Human Subjects”. American Journal of Medicine, pp 672-689, Oct. 1960.
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Bibliografia
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