In vitro evaluation of degradable electrospun polylactic acid/bioactive calcium phosphate ormoglass scaffolds

• Autorzy: Majchrowicz Anna , Roguska A. , Krawczyńska A. , Lewandowska M. , Martí‑Muñoz J. , Engel E. , Castano O.

Identyfikatory

DOI

10.1007/s43452-020-00052-y

• Języki publikacji: EN

Abstrakty

EN

Nowadays, the main limitation for clinical application of scaffolds is considered to be an insufficient vascularization of the implanted platforms and healing tissues. In our studies, we proposed a novel PLA-based hybrid platform with aligned and random fibrous internal structure and incorporated calcium phosphate (CaP) ormoglass nanoparticles (0, 10, 20 and 30 wt%) as an off-the-shelf method for obtaining scaffolds with pro-angiogenic properties. Complex morphological and physicochemical evaluation of PLA–CaP ormoglass composites was performed before and after in vitro degradation test in SBF solution to assess their biological potential. The degradation process of PLA–CaP ormoglass composites was accompanied by numerous CaP-based precipitations with extended topography and cauliflower-like shape which may enhance bonding of the material with the bone tissue and accelerate the regenerative process. Random fiber orientation was preferable for CaP compounds deposition upon in vitro degradation. CaP compounds precipitated firstly for randomly oriented composite nonwovens with 20 and 30 wt% addition of ormoglass. Moreover, the preliminary bioactivity test has shown that BSA adsorbed to PLA–CaP ormoglass composites (both aligned and randomly oriented) with 20 and 30 wt% of ormoglass nanoparticles which was not observed for pure PLA scaffolds.

Słowa kluczowe

EN

composites; PLA; calcium phosphate ormoglass; electrospinning; degradation

PL

kompozyty; fosforan wapnia; szkło; degradacja

• Wydawca: Springer ; Wrocław University of Science and Technology
• Czasopismo: Archives of Civil and Mechanical Engineering
• Rocznik: 2020
• Tom: Vol. 20, no. 2
• Strony: 296--306
• Opis fizyczny: Bibliogr. 40 poz., rys., wykr.

Twórcy

autor

Majchrowicz Anna

• Faculty of Materials Science and Engineering, Warsaw University of Technology (WUT), Wołoska 141, 02-507 Warsaw, Poland

autor

Roguska A.

• Institute of Physical Chemistry, Polish Academy of Sciences, Warsaw, Poland

autor

Krawczyńska A.

• Faculty of Materials Science and Engineering, Warsaw University of Technology (WUT), Wołoska 141, 02-507 Warsaw, Poland

autor

Lewandowska M.

• Faculty of Materials Science and Engineering, Warsaw University of Technology (WUT), Wołoska 141, 02-507 Warsaw, Poland

autor

Martí‑Muñoz J.

• Biomaterials for Regenerative Therapies, Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain
• CIBER en Bioingeniería, Biomateriales y Nanomedicina, CIBER-BBN, Zaragoza, Spain
• Materials Sciences and Metallurgy, Universitat Politècnica de Catalunya (UPC), Barcelona, Spain

autor

Engel E.

• Biomaterials for Regenerative Therapies, Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain

autor

Castano O.

• Biomaterials for Regenerative Therapies, Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain
• CIBER en Bioingeniería, Biomateriales y Nanomedicina, CIBER-BBN, Zaragoza, Spain
• Electronics and Biomedical Engineering, Universitat de Barcelona (UB), Barcelona, Spain
• Institute of Nanoscience and Nanotechnology, University of Barcelona (UB), 08028 Barcelona, Spain

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Uwagi

PL

Opracowanie rekordu ze środków MNiSW, umowa Nr 461252 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2021)