Combined analysis of onco-epidemiological studies of the relationship between lung cancer and indoor radon exposure

• Autorzy: Yarmoshenko Ilia V. , Malinovsky Georgy P.

Identyfikatory

DOI

10.2478/nuka-2020-0012

• Konferencja: III International Conference „Radon in the Environment” (3 ; 27-31 May 2019 ; Krakow, Poland)
• Języki publikacji: EN

Abstrakty

EN

Objectives: Recent results of epidemiological and medical statistics studies of lung cancer and indoor radon in different regions of the world make a relevant new combined analysis of residential exposure health effects. In particular, new data were obtained by means of a meta-analysis of case-control studies as well as taking into account a confounding effect of human papillomavirus infection in studies of geographically aggregated data. Materials and methods: Two sources of epidemiological data are considered: (1) studies of ecological design and (2) case-control studies. Ecological studies included the analysis performed for the USA counties and Russian oblasts with adjusting for the main confounders. Data on the case-control studies were gained from the meta-analysis of 31 individual studies with a weighting of obtained odds ratios according to the quality of radon exposure reconstruction and size of the reference group. Estimations of lung cancer excess relative risk (ERR) associated with indoor radon exposure are combined. Results: Two types of epidemiological study design provided generally consistent EER estimations. The combined value of ERR due to radon exposure is 0.14 (90% CI: 0.10–0.18) per 100 Bq/m3 . Conclusion: Available geographically aggregated data in regions of Russia and the United States and the meta-analysis of case-control studies conducted in a large number of countries confirm the association of lung cancer with indoor radon exposure.

Słowa kluczowe

EN

lung cancer; radon; relative risk

• Wydawca: Institute of Nuclear Chemistry and Technology
• Czasopismo: Nukleonika
• Rocznik: 2020
• Tom: Vol. 65, No. 2
• Strony: 83--88
• Opis fizyczny: Bibliogr. 23 poz., rys

Twórcy

autor

Yarmoshenko Ilia V.

• Institute of Industrial Ecology UB RAS Sophy Kovalevskoy 20 St., Ekaterinburg, Russia

autor

Malinovsky Georgy P.

• Institute of Industrial Ecology UB RAS Sophy Kovalevskoy 20 St., Ekaterinburg, Russia

Bibliografia

• 1. United Nations Environment Programme. (2016). Radiation: effects and sources. UNEP.
• 2. Yarmoshenko, I., Vasilyev, A., Malinovsky, G., Bossew, P., Žunić, Z. S., Onischenko, A. & Zhukovsky, M. (2016). Variance of indoor radon concentration: Major infl uencing factors. Sci. Total Environ., 15(541), 155–160. DOI: 10.1016/j.scitotenv.2015.09.077.
• 3. Lubin, J. H., Boice, J. D., Edling, C., Hornung, R. W., Howe, G., Kunz, E., Kusiak, R. A., Morrison, H. I., Radford, E. P., Samet, J. M., Tirmarche, M., Woodward, A., Xiang, Y. S., & Pierce, D. A. (1994). Radon and lung cancer risk: A joint analysis of 11 underground miner studies. Bethesda, MD: U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health. (NIH Publication no. 94-3644).
• 4. Committee on Health Risks of Exposure to Radon (BEIR VI). (1999). Health effects of exposure to radon. Washington, D.C.: National Academy Press.
• 5. Darby, S., Hill, D., Auvinen, A., Barros-Dios, J. M., Baysson, H., Bochicchio, F., Deo, H., Falk, R., Forastiere, F., Hakama, M., Heid, I., Kreienbrock, L., Kreuzer, M., Lagarde, F., Mäkeläinen, I., Muirhead, C., Oberaigner, W., Pershagen, G., Ruano-Ravina, ., Ruosteenoja, E., Schaffrath Rosario, A., Tirmarche, M., Tomáscaronek, L., Whitley, E., Wichmann, H. -E., & Doll, R. (2005). Radon in homes and risk of lung cancer: collaborative analysis of individual data from 13 European case-control studies. Br. Med. J., 330(7485), 223–227. DOI: 10.1136/bmj.38308.477650.63.
• 6. International Commission on Radiological Protection. (2014). Radiological protection against radon exposure. (ICRP Publication 126). Ann. ICRP, 43(3).
• 7. Stidley, C. A., & Samet, J. M. (1993). A review of ecologic studies of lung cancer and indoor radon. Health Phys., 65(3), 234–251. DOI: 10.1097/00004032-199309000-00001.
• 8. Klein, F., Amin Kotb, W. F., & Petersen, I. (2009). Incidence of human papilloma virus in lung cancer. Lung Cancer, 65(1), 13–18. DOI: 10.1016/j.lungcan.2008.10.003.
• 9. Xiong, W. M., Xu, Q. P., Li, X., Xiao, R. D., Cai, L., & He, F. (2017). The association between human papillomavirus infection and lung cancer: a system review and meta-analysis. Oncotarget, 8(56), 96419–96432. DOI: 10.18632/oncotarget.21682.
• 10. Tsyganov, M. M., Pevzner, A. M., Ibragimova, M. K., Deryusheva, I. V., & Litviakov, N. V. (2019). Human papillomavirus and lung cancer: an overview and a meta-analysis. J. Cancer Res. Clin. Oncol., 145(8), 1919–1937. DOI: 10.1007/s00432-019-02960-w.
• 11. Malinovsky, G., Yarmoshenko, I., & Zhukovsky, M. (2018). Radon, smoking and HPV as lung cancer risk factors in ecological studies. Int. J. Radiat. Biol., 94(1), 62–69. DOI: 10.1080/09553002.2018.1399225.
• 12. Malinovsky, G., Yarmoshenko, I., & Vasilyev, A. (2019). Meta-analysis of case-control studies on the relationship between lung cancer and indoor radon exposure. Radiat. Environ. Biophys., 58(1), 39–47. DOI: 10.1007/s00411-018-0770-5.
• 13. Yarmoshenko, I. V., & Malinovsky, G. P. (2016). Lung cancer mortality and radon exposure in Russia. Nukleonika, 61(3), 263–268. DOI: 10.1515/nuka-2016-0044.
• 14. Malinovsky, G. P., Yarmoshenko, I. V., & Zhukovsky, M. V. (2017). Radon, smoking and human papilloma virus as risk factors for lung cancer in an environmental epidemiological study. Radiatsionnaya Gygiena, 10(2), 106–114. DOI: 10.21514/1998-426X-2017-10-2-106-114. (in Russian).
• 15. International Commission on Radiological Protection. (2010). Lung cancer risk from radon and progeny and statement on radon. (ICRP Publication 115). Ann. ICRP, 40(1).
• 16. Krewski, D., Lubin, J. H., Zielinski, J. M., Alavanja, M., Catalan, V. S., Field, R. W., Klotz, J. B., Létourneau, E. G., Lynch, C. F., Lyon, J. I., Sandler, D. P., Schoenberg, J. B., Steck, J. A., Stolwijk, J. A., Weinberg, C., & Wilcox, H. B. (2005). Residential radon and risk of lung cancer. A combined analysis of 7 North American case-control studies. Epidemiology, 16(2), 137–145. DOI: 10.1097/01.ede.0000152522.80261.e3.
• 17. Lubin, J. H., Wang, Z. Y., Boice, J. D. Jr, Xu, Z. Y., Blot, W. J., De Wang, L., & Kleinerman, R. A. (2004). Risk of lung cancer and residential radon in China: pooled results of two studies. Int. J. Cancer, 109(1), 132–137. DOI: 10.1002/ijc.11683.
• 18. Cohen, B. L. (1995). Test of the linear-no threshold theory of radiation carcinogenesis for inhaled radon decay products. Health Phys., 68(2), 157–174. DOI: 10.1097/00004032-199502000-00002.
• 19. Puskin, J. S. (2003). Smoking as a confounder in ecologic correlations of cancer mortality rates with average county radon levels. Health Phys., 84(4), 526–532. DOI: 10.1097/00004032-200304000-00012.
• 20. Onishchenko, A., & Zhukovsky, M. (2019). The influence of uncertainties of radon exposure on the results of case-control epidemiological study. Int. J. Radiat. Biol., 95(3), 354–359. DOI: 10.1080/09553002.2019.1547846.
• 21. Fearn, T., Hill, D. C., & Darby, S. C. (2008). Measurement error in the explanatory variable of a binary regression: regression calibration and integrated conditional likelihood in studies of residential radon and lung cancer. Statist. Med., 27, 2159–2176. DOI: 10.1002/sim.3163.
• 22. Yarmoshenko, I., Malinovsky, G., Vasilyev, A., & Zhukovsky, M. (2015). Reconstruction of national distribution of indoor radon concentration in Russia using results of regional indoor radon measurement programs. J. Environ. Radioact., 150, 99–103. DOI: 10.1016/j.jenvrad.2015.08.007.
• 23. Kaprin, A. D., Starinsky, V. V., & Petrova, G. V. (2019). Malignant neoplasm in Russia in 2018 (morbidity and mortality). Moscow: P. Herzen Moscow Oncology Research Institute. (in Russian)

Uwagi

Opracowanie rekordu ze środków MNiSW, umowa Nr 461252 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2020).