Alkaloidy kory chinowej : małe cząsteczki, które wiele mogą

• Autorzy: Kacprzak K. , Czarnecki P.

Warianty tytułu

EN

Cinchona alkaloids : small hardworkers

• Języki publikacji: PL

Abstrakty

EN

Cinchona alkaloids comprising quinine, quinidine, cinchonidine and cinchonine as the major members constitute a unique class of quinoline alkaloids with tremendous impact on human civilization (Section 1). The odyssey of Cinchona alkaloids began with the discovery of their antimalarial properties followed by antiarrhytmic action of quinidine. Currently medicinal chemistry of Cinchona alkaloids derivatives develops rapidly and many other activities such as cytotoxic, multidrug resistance inhibitory have been demonstrated (Section 5) [5]. Beside medicine Cinchona alkaloids gave also the fundaments of stereochemistry and asymmetric synthesis. An extraordinary catalytic potency of parent and modified Cinchona alkaloids (deserving privileged catalyst classification) include more than 50 types of diverse stereoselective reactions, with few spectacular such as asymmetric dihydroxylation of alkenes or heterogeneous α-ketoesters hydrogenation (Section 3) [3]. Last but not least the portfolio of applications of Cinchona alkaloids includes resolution of racemates by diastereomeric crystallization or by the use of Cinchona- -based chiral stationary phases for ion-exchange enantioselective chromatography and other recognition or sensing systems (Section 4) [166]. Easy transformation of Cinchona alkaloids (for example by click chemistry) into other chiral and modular building blocks together with current pressure on a more intense exploration of sustainable products make cinchona alkaloids of primary importance for modern synthetic, catalytic and medicinal chemistry. The aim of this review which covers over 200 references is to briefly summarize all aspects of Cinchona alkaloid chemistry and biology with the special emphasis on new applications.

Słowa kluczowe

PL

chinina; alkaloidy kory chinowej; chinidyna; synteza asymetryczna; rozdział enancjomerów; chiralność

EN

quinine; cinchona alkaloids; quinidine; asymmetric synthesis; enantiomer separation; chirality

• Wydawca: Polskie Towarzystwo Chemiczne
• Czasopismo: Wiadomości Chemiczne
• Rocznik: 2013
• Tom: [Z] 67, 5-6
• Strony: 443--493
• Opis fizyczny: Bibliogr. 233 poz., rys., schem.

Twórcy

autor

Kacprzak K.

• Wydział Chemii UAM ul. Umultowska 89B, 61-614 Poznań

autor

Czarnecki P.

• Wydział Chemii UAM ul. Umultowska 89B, 61-614 Poznań

Bibliografia

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