The intima with early atherosclerotic lesions is load-bearing component of human thoracic aorta

• Autorzy: Kobielarz M. , Kozuń M. , Kuzan A. , Maksymowicz K. , Witkiewicz W. , Pezowicz C.

Identyfikatory

DOI

10.1016/j.bbe.2016.10.008

• Języki publikacji: EN

Abstrakty

EN

The aim of the study was to evaluate the mechanical properties of the adventitia, media, and especially intima of the human thoracic aortic wall in the early stages of atherosclerosis (stage I to III according to the Stary's classification). Histological and immunohistochemical techniques were used to evaluate the severity of atherosclerosis and the correctness of separation of the respective layers. Circumferential specimens of the adventitia, media, and intima (n = 193) were prepared from 27 arteries. The mechanical properties, i.e. the ultimate tensile strength, the maximum strain, and the maximum tangential elastic moduli, were determined in uniaxial tensile test and presented as a median (Me). The tensile strength of the intima (Me = 105 kPa) is comparable to the media (Me = 123 kPa) and lower than for the adventitia (Me = 808.5 kPa). The intima also undergoes the lowest maximum strain (Me = 0.008), and its elastic modulus (Me = 11510 kPa) is significantly higher compared to the media (Me = 5280 kPa). Therefore, presented results indicate that even in the early stages of atherosclerotic development the intima takes part in the process of mechanical loads bearing.

Słowa kluczowe

EN

atherosclerosis; intima; mechanical properties

PL

stwardnienie tętnicy; błona wewnętrzna naczynia; właściwości mechaniczne

• Wydawca: Nałęcz Institute of Biocybernetics and Biomedical Engineering of the Polish Academy of Sciences ; Elsevier
• Czasopismo: Biocybernetics and Biomedical Engineering
• Rocznik: 2017
• Tom: Vol. 37, no. 1
• Strony: 35--43
• Opis fizyczny: Bibliogr. 34 poz., rys., tab., wykr.

Twórcy

autor

Kobielarz M.

• Department of Biomedical Engineering, Mechatronics and Theory of Mechanisms, Wroclaw University of Technology, Lukasiewicza 7/9, 50-371 Wroclaw. Fax: [phone]

autor

Kozuń M.

• Department of Biomedical Engineering, Mechatronics and Theory of Mechanisms, Wroclaw University of Technology, Lukasiewicza 7/9, 50-371 Wroclaw. Fax: [phone]

autor

Kuzan A.

• Department of Medical Biochemistry, Wroclaw Medical University, Wroclaw, Poland

autor

Maksymowicz K.

• Department of Forensic Medicine, Wroclaw Medical University, Wroclaw, Poland

autor

Witkiewicz W.

• Wrovasc – Integrated Cardiovascular Centre, Regional Hospital in Wroclaw, Research and Development Center, Wroclaw, Poland

autor

Pezowicz C.

• Department of Biomedical Engineering, Mechatronics and Theory of Mechanisms, Wroclaw University of Technology, Lukasiewicza 7/9, 50-371 Wroclaw. Fax: [phone]

Bibliografia

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Uwagi

PL

Opracowanie ze środków MNiSW w ramach umowy 812/P-DUN/2016 na działalność upowszechniającą naukę (zadania 2017).