The Technological Parameter Optimization of Rapid Freeze Prototyping for 3D Tissue Scaffold Fabrication

• Autorzy: Liu D. , Liu Y. , Jing C. , Wang Q. , Li Q. , Hu Q.

Warianty tytułu

PL

Optymalizacja parametrów technologicznych przy wytwarzaniu struktur trójwymiarowych metoda RFP

• Języki publikacji: EN

Abstrakty

EN

When using the Rapid freeze prototype (RFP) process to fabricate 3D tissue bone scaffold, the selecting of technological parameters directly affects lap ratio, which is the foundation of continuous fabrication and scaffold quality. Through analyzing the force of non-solidified fiber, Velocity ratio, liquid temperature, solid content, nozzle diameter and row spacing have been chosen as the influence factors and the L16 (45) orthogonal experiments have been done The experiments result is that material viscosity and row spacing is the most important factors for lap ratio influence. Optimal parameters combination has been got by range analysis. Finally, the mixed solution of gelatin-chitosan experiment with the optimal parameters has successfully produced multilayer tissue bone scaffold, including multiple scale structure.

PL

W artykule zaprezentowano process wytwarzania materiałów trójwymiarowych metoda gwałtownego oziębiania – RFP (rapid freeze prototype). Materiałem wyjściowym jest mieszanina żelatyny i chitozanu. Na proces tworzenia struktury ma wpływ wiele czynników, takich jak: temperatura cieczy, zawartość składnika stałego, rozmiary węzłów, średnica i odstępy między rzędami.

Słowa kluczowe

EN

orthogonal experiment; optimal parameters; rapid freeze prototype

PL

optymalizacja parametrów; metoda gwałtownego oziębiania; trójwymiarowe modelowanie

• Wydawca: Wydawnictwo SIGMA-NOT
• Czasopismo: Przegląd Elektrotechniczny
• Rocznik: 2012
• Tom: R. 88, nr 9b
• Strony: 47--50
• Opis fizyczny: Bibliogr. 14 poz., rys., tab.

Twórcy

autor

Liu D.

• University of Shanghai

autor

Liu Y.

• University of Shanghai

autor

Jing C.

• University of Shanghai

autor

Wang Q.

• University of Shanghai

autor

Li Q.

• University of Shanghai

autor

Hu Q.

• University of Shanghai

Bibliografia

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• [3] Wu Rendong. STUDY ON LOW-TEMPERATURE ICE-MODEL FORMING BASED ON RAPID PROTOTYPE[J], Gryogenics, 2003,4：36-42.
• [4] Chao Feng, Yongnian Yan, Renji Zhang. Comparison and analysis of continuously jetting and discretely jetting method i(P/V) Tf(℃) w(%) D(mm) L(mm) Wr(%) used in rapid ice prototype forming [J]. Materials and Design, 2002, 23:77-81.
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• [6] ZHANG Renji. Novel Rapid Prototyping Method to Fabricate Poly (lactide-co-glycolide) Scaffold with High Porosity [J]. Chinese Journal of Mechanical Engineering, 2010,46(5):105-109.
• [7] Frances D. Bryant, Ming C. Leu. Predictive Modeling and Experimental Verification of Temperature and Concentration in Rapid Freeze Prototyping With Support Material [J]. Journal of Manufacturing Science and Engineering, 2009, 131: 041020_1-041020_9.
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• [9] Dietmar W H, Thorsten S, Iwan Z, et al Mechanical properties and cell cultural response of polycap rolact one scaffolds designed and fabricated via fused deposition modeling [J]. J Biomedical Materials Research, 2001, 55(2): 203-216.
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• [12] Cong Bang Pham, Kah Fai Leong, Tze Chiun Lim and Kerm Sin Chian.Rapid freeze prototyping technique in bio-plotters for tissue scaffold fabrication [J]. Rapid Prototyping Journal, 2008,14:246–253.
• [13] Dellinger, Jennifer G. Bone response to 3D periodic hydroxyapatite scaffolds with and without tailored microporosity to deliver bone morphogenetic protein 2[J]. Journal of Biomedical Materials Research - Part A, 2006, 76(2):366-376.
• [14] Joseph R. Woodard, Amanda J. Hilldore, Sheeny K. Lan and etc. The mechanical properties and osteoconductivity of hydroxyapatite bone scaffold with multi-scale porosity [J]. Biomaterials, 2007, 28:45–54.