In situ methanolic solvent synthesis, spectroscopic and thermogravimetric characterizations of three new transition metal complexes of trimethoprim drug

• Autorzy: Refat Moamen S. , Al-Humaidi Jehan Y. , El-Sayed Mohamed Y. , Hassan Reham F.

Identyfikatory

DOI

10.2478/pjct-2021-0009

• Języki publikacji: EN

Abstrakty

EN

Trimethoprim drug (TMP) complexes of copper (II), cobalt (II), and nickel (II) were prepared and discussed by using elemental analysis (C, H, N analysis), magnetic, molar conductance, FTIR, Raman spectroscopy, electron spin resonance (ESR) and UV-vis spectroscopy analyses. TMP drug coordinated as a tridentate ligand towards the respected three metal ions through two nitrogen atoms of amino groups and nitrogen atom of pyrimidine ring which flanked between –NH₂ groups, these assignments confirmed by spectroscopic, magnetic, ESR and thermogravimetric analyses with formulas [Cu(TMP)(H₂O)₃]Cl₂, [Co(TMP)(H₂O)₃]Cl₂ and [Ni(TMP) (H₂O)]Cl₂. Copper (II) and cobalt (II) complexes have an octahedral geometrical structure included one TMP molecule, three coordinated water molecules and two uncoordinated chlorine atoms while, nickel(II)–TMP complex has a tetrahedral geometric configuration that involved one TMP molecule, one coordinated water molecule and two uncoordinated chlorine atoms. The activation energies and other kinetic thermodynamic parameters were estimated based on the employed of the Coats-Redfern and Horowitz-Metzger equations. The nano–structured form of the synthesized TMP complexes was confirmed dependent on the transmission electron microscopy (TEM).

Słowa kluczowe

EN

complexation; trimethoprim; transition metals; TGA; thermogravimetric analysis; FTIR; Fourier transform infrared spectroscopy; ESR; kinetic thermodynamic parameters

• Wydawca: West Pomeranian University of Technology. Publishing House
• Czasopismo: Polish Journal of Chemical Technology
• Rocznik: 2021
• Tom: Vol. 23, nr 1
• Strony: 60--67
• Opis fizyczny: Bibliogr. 45 poz., rys., tab., wz.

Twórcy

autor

Refat Moamen S.

• Department of Chemistry, College of Science Taif University Saudi Arabia

autor

Al-Humaidi Jehan Y.

• Department of Chemistry, College of Science Princess Nourah bint Abdulrahman University Riyadh

autor

El-Sayed Mohamed Y.

• Chemistry Department, College of Science, Jouf University, P.O. Box: 2014, Sakaka, Saudi Arabia
• Department of Chemistry, Faculty of Science, Zagazig University, Egypt

autor

Hassan Reham F.

• Department of Chemistry, Faculty of Science Helwan University Cairo, Egypt

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Uwagi

Opracowanie rekordu ze środków MNiSW, umowa Nr 461252 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2021).