Geometrical Accuracy and Strength of Micro-Needles Made of Polylactide by Fused Filament Fabrication Method

• Autorzy: Wichniarek Radosław , Kuczko Wiesław , Tomczak Dorota , Nowicka Ariadna B. , Wojtyłko Monika , Froelich Anna , Osmałek Tomasz

Identyfikatory

DOI

10.12913/22998624/174079

• Języki publikacji: EN

Abstrakty

EN

Additive manufacturing is a technology that can be successfully used in pharmacy and medicine. One of the examples of products that can be additively manufactured are microneedle systems. The specificity of these products, which are used for transdermal drug delivery, makes additive manufacturing a perfect choice for related research. However, the dimensions of microneedles usually do not exceed 2 mm, which means that manufacturing them using the most widely available additive manufacturing method, Fused Deposition Modelling (FDM), is problematic. In this study, the authors decided to investigate the possibilities of manufacturing microneedle systems using the FDM method in such a way as to minimize or exclude the need for post-processing. Five types of microneedle geometries were tested in four sizes, examining how changing the values of FDM process parameters would affect the accuracy of reproducing the digital geometry of the microneedles. From the point of view of the application of microneedle systems, it is not only necessary to obtain the designed shape of the microneedles, but also to maintain their appropriate strength. The study presents the results of the bending and compression strength of microneedles made of polylactic acid.

Słowa kluczowe

EN

additive manufacturing; microneedle; 3D printing; transdermal drug delivery; polylactic acid

• Wydawca: Lublin University of Technology ; Polish Society of Ecological Engineering (PTIE), Branch of PTIE in Lublin
• Czasopismo: Advances in Science and Technology. Research Journal
• Rocznik: 2023
• Tom: Vol. 17, no 6
• Strony: 116--126
• Opis fizyczny: Bibliogr. 21 poz., fig.

Twórcy

autor

Wichniarek Radosław

• Institute of Materials Technology, Faculty of Mechanical Engineering, Poznan University of Technology, 5 M. Skłodowska-Curie Square, 60-965 Poznan, Poland

• https://orcid.org/0000-0003-0714-7462

autor

Kuczko Wiesław

• Institute of Materials Technology, Faculty of Mechanical Engineering, Poznan University of Technology, 5 M. Skłodowska-Curie Square, 60-965 Poznan, Poland

autor

Tomczak Dorota

• Institute of Chemical Technology and Engineering, Faculty of Chemical Technology, Poznan University of Technology, Berdychowo 4, 60-965 Poznan, Poland

autor

Nowicka Ariadna B.

• Faculty of Materials Engineering and Technical Physics, Poznan University of Technology, Piotrowo 3, 60-965 Poznan, Poland

autor

Wojtyłko Monika

• Department of Pharmaceutical Technology, Poznan University of Medical Sciences, 6 Grunwaldzka Street, 60-780 Poznań, Poland

autor

Froelich Anna

• Department of Pharmaceutical Technology, Poznan University of Medical Sciences, 6 Grunwaldzka Street, 60-780 Poznań, Poland

autor

Osmałek Tomasz

• Department of Pharmaceutical Technology, Poznan University of Medical Sciences, 6 Grunwaldzka Street, 60-780 Poznań, Poland

Bibliografia

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Uwagi

Opracowanie rekordu ze środków MNiSW, umowa nr SONP/SP/546092/2022 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2024).