Static compression optical coherence elastography for the measurement of porcine corneal mechanical properties ex-vivo

• Autorzy: Quince Zachery , Alonso-Caneiro David , Read Scott A. , Harkin Damien G. , Collins Michael J.

Identyfikatory

DOI

10.1016/j.bbe.2024.08.006

• Języki publikacji: EN

Abstrakty

EN

Significance: The biomechanical properties of the cornea are important for vision and ocular health. Optical coherence elastography (OCE) has the potential to improve our capacity to measure these properties. Aim: This study tested a static compression OCE method utilising a commercially available optical coherence tomography (OCT) device, to estimate the Young’s modulus of ex-vivo porcine corneal tissue. Approach: OCT was used to image corneal tissue samples before and during loading by static compression. The compressive force was measured with a piezoresistive force sensor, and tissue deformation was quantified through automated image analysis. Ten ex-vivo porcine corneas were assessed and the corneal thickness was also measured to assess the impact of corneal swelling. Results: An average (standard deviation) Young’s modulus of 0.271 (+/- 0.091) MPa was determined across the 10 corneas assessed. There was a mean decrease of 1.78 % in corneal thickness at the end of the compression series. These results showed that there was a moderate association between corneal thickness and the Young’s modulus recording (R² = 0.274). Conclusions: Optical coherence elastography utilising clinical instrumentation, can reliably characterise the mechanical properties of the cornea. These results support the further investigation of the technique for in-vivo measurement of the mechanical properties of the human cornea.

Słowa kluczowe

EN

optical coherence elastography; boundary segmentation; animal model

PL

optyczna elastografia koherentna; segmentacja graniczna; model zwierzęcy

• Wydawca: Nałęcz Institute of Biocybernetics and Biomedical Engineering of the Polish Academy of Sciences ; Elsevier
• Czasopismo: Biocybernetics and Biomedical Engineering
• Rocznik: 2024
• Tom: Vol. 44, no. 3
• Strony: 609--616
• Opis fizyczny: Bibliogr. 46 poz., rys., tab., wykr.

Twórcy

autor

Quince Zachery

• School of Engineering, University of Southern Queensland, Springfield, Queensland, Australia
• Contact Lens and Visual Optics Laboratory, Centre for Vision and Eye Research, Optometry and Vision Science, Queensland University of Technology, Brisbane, Australia

autor

Alonso-Caneiro David

• Contact Lens and Visual Optics Laboratory, Centre for Vision and Eye Research, Optometry and Vision Science, Queensland University of Technology, Brisbane, Australia
• School of Science, Technology and Engineering, University of Sunshine Coast, Petrie, Queensland, Australia

autor

Read Scott A.

• Contact Lens and Visual Optics Laboratory, Centre for Vision and Eye Research, Optometry and Vision Science, Queensland University of Technology, Brisbane, Australia

autor

Harkin Damien G.

• Centre for Vision and Eye Research, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology (QUT), Brisbane, QLD, Australia

autor

Collins Michael J.

• Contact Lens and Visual Optics Laboratory, Centre for Vision and Eye Research, Optometry and Vision Science, Queensland University of Technology, Brisbane, Australia

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Uwagi

Opracowanie rekordu ze środków MNiSW, umowa nr POPUL/SP/0154/2024/02 w ramach programu "Społeczna odpowiedzialność nauki II" - moduł: Popularyzacja nauki (2025).