Spectral correlation analysis of Hammett substituent constants and biological activities of some (E)-1-(4-phenoxyphenyl)-3-phenylprop-2-en-1-ones

• Autorzy: Kalyanasundaram N. , Sakthinathan S. P. , Suresh R. , Kamalakkannan D. , Joseph S. J. , Vanangamudi G. , Thirunarayanan G.
• Języki publikacji: EN

Abstrakty

EN

A series of aryl chalcones have been synthesized from 4-phenoxyacetophonone with various substituted benzaldehydes. The purity of all chalcones has been checked using their physical constants and spectral data. These spectral data have been correlated with Hammett substituent constants and F and R parameters using single and multi-linear regression analysis. From the results of statistical analysis, the effect of substituents on the above spectral data has been studied. The single parameter correlation with few Hammett constants and F and R parameters gave satisfactory correlation coefficients whereas all multiple correlations gave satisfactory correlation coefficients with Resonance, Field and Swain-Lupton’s parameters. The antimicrobial activities of all chalcones have been studied using Bauer-Kirby method.

Słowa kluczowe

EN

substituted styryl 4-phenoxyphenylketones; UV-spectra; IR spectra; NMR spectra; Hammett constants; substituent effects; regression analysis and antimicrobial activities

• Wydawca: Przedsiębiorstwo Wydawnictw Naukowych "DARWIN"
• Czasopismo: International Letters of Chemistry, Physics and Astronomy
• Rocznik: 2014
• Tom: Vol. 9
• Strony: 23--47
• Opis fizyczny: Bibliogr. 40 poz., tab., zdj.

Twórcy

autor

Kalyanasundaram N.

• PG & Research Department of Chemistry, Government Arts College, C-Mutlur, Chidambaram - 608102, India

autor

Sakthinathan S. P.

• PG & Research Department of Chemistry, Government Arts College, C-Mutlur, Chidambaram - 608102, India

autor

Suresh R.

• PG & Research Department of Chemistry, Government Arts College, C-Mutlur, Chidambaram - 608102, India

autor

Kamalakkannan D.

• PG & Research Department of Chemistry, Government Arts College, C-Mutlur, Chidambaram - 608102, India

autor

Joseph S. J.

• PG & Research Department of Chemistry, Government Arts College, C-Mutlur, Chidambaram - 608102, India

autor

Vanangamudi G.

• PG & Research Department of Chemistry, Government Arts College, C-Mutlur, Chidambaram - 608102, India

autor

Thirunarayanan G.

• Department of Chemistry, Annamalai University, Annamalainagar - 608002, India

Bibliografia

• [1] Ranganathan K., Arulkumaran R., Kamalakkannan D., Vanangamudi G., Thirunarayanan G., IUP J. Chem. 4(2) (2011) 60-69.
• [2] Wang Y. H., Zou J. W., Zhang B., Lu Y. X., Jin H. X., Yu Q. S., J Mol Struct (Theochem) 755(31) (2005) 1-2.
• [3] Thirunarayanan G., Vanangamudi G., Subramanian M., Umadevi U., Sakthinathan, S. P., Sundararajan R., Elixir Org. Chem. 39(2011) 4643-4653.
• [4] Yankep E., Fomumand Z. T, Dangne E., Phytochem. 46 (1997) 59.
• [5] Mulliken R. S., J. Chem. Phys. 7 (1939) 121-131.
• [6] Smith M. B., March J., Adv. Org. Chem, Reac, Mech & Stru, Wiley: New York, 2001, 1218-1224.
• [7] Deli J. Lorand, T. Szabo, D. Foldesi, A. Pharmaz. 39 (1984) 539.
• [8] Winternitz F., Conder G., Vassort P., Tetrahedron Lett. 26 (1986) 5981.
• [9] Misra S. S., Tewari R. S., J Ind. Chem. Soc. 50 (1973) 68.
• [10] Thirunarayanan G., J. Ind. Chem. Soc. 84 (2008) 447.
• [11] Sivakumar M., Phrabusreeneivasan S., Kumar V., Doble M., Bioorg. Med. Chem. Lett. 17(10) (2007) 3169.
• [12] Weber M. W., Hunsaker L. A., Abcouwer S. F., Decker L. M., Vander Jagat D. L., Bioorg. Med. Chem. 13 (2005) 3811.
• [13] Parmer V. S., Bishit K. S., Jain R., Singh S., Sharma S. K., Gupta S., Malhotra S., Tyagi O. D., Vardhan A., Pati H. N., Berghe D. V., Vlietinek A. J., Ind. J. Chem. 35B (1996) 220.
• [14] Deng J., Sanchez T., M. Lalith Q. A., Bioorg. Med. Chem. 15(14) (2007) 4985.
• [15] Dominguez J. N., Leon C., Rodrigues J., IL Farmaco. 60(4) (2005) 307.
• [16] Arulkumaran R., Sundararajan R., Vanangamudi G., Subramanian M., Ravi K., Sathiyendidran V., Srinivasan S.Thirunarayanan G., IUP J. Chem. 3(1) (2010) 82-98.
• [17] Mirinda C. L., Aponso G. L., Stevens J. F, Cancer Lett. 149(1-2) (2000) 21.
• [18] Sung D. D., Ananthakrishna Nadar P., Ind. J. Chem. 39A (2000) 1066.
• [19] Bauer A. W., Kirby W. M., Sherris J. C., Truck M., Am. J. Clin. Pathol. 45 (1996) 493-498.
• [20] Drabu Sushma, Asian Journal of Chemistry V19(7) (2007) 5743-5746.
• [21] Mala V., Sathiyamoorthy K., Sakthinathan S. P., Kamalakkannan D., Suresh R., Vanangamudi G., Thirunarayanan G., Q-Science Connect. 2013. DOI: http://dx.doi.org/10.5339/connect.2013.
• [22] Kamalakkannan D., Vanangamudi G., Arulkumaran R., Thirumurthy K., Mayavel P., Thirunarayanan G., Elixir Org. Chem. 46 (2012) 8157-8166.
• [23] Sathiyamoorthi K., Mala V., Sakthinathan S. P., Suresh R., Kamalakkannan D., Vanangamudi G., Thirunarayanan G., Spectrochim. Acta Part 112A (2013) 245-256.
• [24] Swain C. G., Lupton E. C. Jr., Am. Chem. Soc. 90 (1968) 4328-4337.
• [25] R. Arulkumaran, S. Vijayakumar, R. Sundararajan, S. P. Sakthinathan, D. Kamalakkannan, R. Suresh, K. Ranganathan, P. R. Rajakumar, G. Vanangamudi, G. Thirunarayanan, International Letters of Chemistry, Physics and Astronomy 5 (2013) 21-38.
• [26] S. P. Sakthinathan, R. Suresh, V. Mala, K.Sathiyamoorthi, D. Kamalakkannan, K. Ranganathan, R. Arulkumaran, S. Vijayakumar, R. Sundararajan, G. Vanangamudi, G. Thirunarayanan, International Letters of Chemistry, Physics and Astronomy 6 (2013) 77-90.
• [27] K. Sathiyamoorthi, V. Mala, R. Suresh, S. P. Sakthinathan, D. Kamalakkannan, K. Ranganathan, R. Arulkumaran, R. Sundararajan, S. Vijayakumar, G. Vanangamudi, G. Thirunarayanan, International Letters of Chemistry, Physics and Astronomy 7(2) (2013) 102-119.
• [28] G. Thirunarayanan, K. G. Sekar, International Letters of Chemistry, Physics and Astronomy 8(2) (2013) 160-174.
• [29] K. G. Sekar, G. Thirunarayanan, International Letters of Chemistry, Physics and Astronomy 8(3) (2013) 249-258.
• [30] S. Vijayakumar, R. Arulkumaran, R. Sundararajan, S. P. Sakthinathan, R. Suresh, D. Kamalakkannan, K. Ranganathan, K. Sathiyamoorthy, V. Mala, G. Vanangamudi, G. Thirunarayanan, International Letters of Chemistry, Physics and Astronomy 9(1) (2013) 68-86.
• [31] G. Thirunarayanan, K. G. Sekar, International Letters of Chemistry, Physics and Astronomy 10(1) (2013) 18-34.
• [32] R. Sundararajan, R. Arulkumaran, S. Vijayakumar, D. Kamalakkannan, R. Suresh, S. John Joseph, K. Ranganathan, S. P. Sakthinathan, G. Vanangamudi, G. Thirunarayanan, International Letters of Chemistry, Physics and Astronomy 1 (2014) 67-73.
• [33] S. John Joseph, R. Arulkumaran, D. Kamalakkannan, S. P. Sakthinathan, R. Sundararajan, R. Suresh, S. Vijayakumar, K. Ranganathan, N. Kalyanasundaram, G. Vanangamudi, G. Thirunarayanan, International Letters of Chemistry, Physics and Astronomy 4 (2014) 48-65.
• [34] G. Thirunarayanan, R. Sundararajan, R. Arulkumaran, International Letters of Chemistry, Physics and Astronomy 4 (2014) 82-97.
• [35] G. Thirunarayanan, International Letters of Chemistry, Physics and Astronomy 4 (2014) 109-116.
• [36] G. Thirunarayanan, International Letters of Chemistry, Physics and Astronomy 5 (2014) 89-98.
• [37] S. John Joseph, D. Kamalakkannan, R. Arulkumaran, S. P. Sakthinathan, R. Suresh, R. Sundararajan, S. Vijayakumar, K. Ranganathan, G. Vanangamudi, G. Thirunarayanan, International Letters of Chemistry, Physics and Astronomy 5 (2014) 99-123.
• [38] G. Thirunarayanan, S. Pazhamalai, K. G. Sekar, International Letters of Chemistry, Physics and Astronomy 8 (2014) 38-46.
• [39] Ranganathan K., et al., International Letters of Chemistry, Physics and Astronomy 4 (2012) 66-75.
• [40] Arulkumaran R., et al., International Letters of Chemistry, Physics and Astronomy 4 (2012) 17-38.