Characterization of biomaterials with reference to biocompatibility dedicated for patient-specific finger implants

• Autorzy: Byrski Adam , Kopernik Magdalena , Major Lukasz , Kasperkiewicz Katarzyna , Dyner Marcin , Lackner Juergen M. , Lumenta David B. , Major Roman

Identyfikatory

DOI

10.37190/ABB-02156-2022-02

• Języki publikacji: EN

Abstrakty

EN

The research was focused on determining basic mechanical properties, surface, and phase structure taking into consideration basic cytotoxicity analysis towards human cells. Methods: Biological tests were performed on human C-12302 fibroblasts cells using 3D-printed Ti6Al4V alloy (Ti64), produced by laser-based powder bed fusion (LB-PBF) and Alumina Toughened Zirconia 20 (ATZ20), produced by lithography-based ceramic manufacturing (LCM). Surface modifications included electropolishing and hydroxyapatite or hydroxyapatite/zinc coating. Structure analysis was carried out using a variety of techniques such as X-Ray diffraction, scanning electron microscopy (SEM), transmission electron microscopy (TEM) and confocal laser scanning microscopy (CLSM), followed by mechanical properties evaluation using nanoindentation testing. Results: Samples subjected to surface modifications showed diversity among surface and phase structure and mechanical properties. However, the cytotoxicity towards tested cells was not significantly higher than the control. Though, a trend was noted among the materials analysed, indicating that HAp/Zn coating on Ti64 and ATZ20 resulted in the best biological performance increasing cell survivability by more than 10%. Conclusions: Hydroxyapatite coating on Ti64 and ATZ20 resulted in the best biological properties. Tested materials are suitable for in vivo toxicity testing.

Słowa kluczowe

EN

laser based-powder bed fusion; lithography; ceramic manufacturing; bone implant; cytotoxicity; micromechanical properties

• Wydawca: Oficyna Wydawnicza Politechniki Wrocławskiej
• Czasopismo: Acta of Bioengineering and Biomechanics
• Rocznik: 2023
• Tom: Vol. 25, no. 1
• Strony: 3--17
• Opis fizyczny: Bibliogr. 50 poz., rys., tab., wykr.

Twórcy

autor

Byrski Adam

• Institute of Metallurgy and Materials Science, Polish Academy of Sciences, Kraków, Poland.

autor

Kopernik Magdalena

• AGH University of Krakow, Kraków, Poland.

autor

Major Lukasz

• Institute of Metallurgy and Materials Science, Polish Academy of Sciences, Kraków, Poland.

autor

Kasperkiewicz Katarzyna

• 3 Institute of Biology, Biotechnology and Environmental Protection, Faculty of Natural Sciences, University of Silesia in Katowice, Katowice, Poland

autor

Dyner Marcin

• Faculty of Science and Technology, Jan Dlugosz University in Czestochowa, Częstochowa, Poland.

autor

Lackner Juergen M.

• 5 JOANNEUM RESEARCH Forschungsgesellschaft mbH, MATERIALS – Institute for Sensors, Photonics and Manufacturing Technologies, Niklasdorf, Austria.

autor

Lumenta David B.

• Research Unit for Digital Surgery, Division of Plastic, Aesthetic and Reconstructive Surgery, Department of Surgery, Medical University of Graz, Austria.

autor

Major Roman

• Institute of Metallurgy and Materials Science, Polish Academy of Sciences, Kraków, Poland.

Bibliografia

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Uwagi

Opracowanie rekordu ze środków MNiSW, umowa nr SONP/SP/546092/2022 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2024).