Effect of activated carbon on methomyl poisoning by urine metabolomics base on gas chromatography–mass spectrometry

• Autorzy: Li L. , Hu L. , Chen B. , Dong Y. , Lin Z. , Wang Z. , Wen C. , Wang X. , Wang S.

Identyfikatory

DOI

10.1556/1326.2017.00146

• Języki publikacji: EN

Abstrakty

EN

In this study, we developed a urine metabolomic method by gas chromatography–mass spectrometry (GC–MS) combination with biomedical results to evaluate the effect of activated carbon on methomyl poisoning rats. The rats were divided into four groups, methomyl group, two activated carbon treatment group, and control group. According to the biochemical results, it indicated that activated carbon treated rats could cause liver and kidney function changes. According to the urine metabolomics results, activated carbon treatment group (10 min) and activated carbon treatment group (30 min) could be distinguished from methomyl group, and activated carbon treatment group (10 min) could be separated from activated carbon treatment group (30 min) rats, which indicated that the treatment of rats by activated carbon in different time had a different effect. The results indicate that metabolomic method by GC–MS may be useful to elucidate activated carbon treated on methomyl poisoning rats.

Słowa kluczowe

EN

Metabolomics; GC–MS; methomyl; urine; rat

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2018
• Tom: Vol. 30, no. 1
• Strony: 21--25
• Opis fizyczny: Bibliogr. 18 poz., rys.

Twórcy

autor

Li L.

• The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou 325000, China

autor

Hu L.

• Department of Pharmacy, The First People's Hospital of Wenling, Wenling 317500, China

autor

Chen B.

• Laboratory Animal Centre of Wenzhou Medical University, Wenzhou 325035, China

autor

Dong Y.

• Laboratory Animal Centre of Wenzhou Medical University, Wenzhou 325035, China

autor

Lin Z.

• Laboratory Animal Centre of Wenzhou Medical University, Wenzhou 325035, China

autor

Wang Z.

• The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou 325000, China

autor

Wen C.

autor

Wang X.

• Analytical and Testing Centre of Wenzhou Medical University, Wenzhou 325035, China

autor

Wang S.

• The Laboratory of Clinical Pharmacy, People's Hospital of Lishui City, Lishui 323000, China

Bibliografia

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Uwagi

PL

Opracowanie rekordu w ramach umowy 509/P-DUN/2018 ze środków MNiSW przeznaczonych na działalność upowszechniającą naukę (2018).