Resolution of propranolol and atenolol enantiomers on β-cyclodextrin-impregnated silica gel layers

• Autorzy: Joshi S , Sharma A.
• Języki publikacji: EN

Abstrakty

EN

Enantiomeric resolution of two commonly used β-blockers, namely, (±)-propranolol and (±)-atenolol, has been achieved on silica gel layers which were bulkimpregnated with β-cyclodextrin. Solvent systems DMF-ethyl acetate-butanol (3:2:5, υ/υ) and butanol-acetic acid-ethyl acetate-ammonia (5:2:2:0.5, υ/υ) successfully resolved the enantiomers of (±)-propranolol and (±)-atenolol, respectively. The spots were located with iodine vapor. The effects of concentration of the chiral selector and mobile phase variation were also studied.

Słowa kluczowe

EN

β-blocker drugs; enantiomeric resolution; β-cyclodextrin; impregnated silica gel plates; iodine vapor detection

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2012
• Tom: Vol. 24, no. 2
• Strony: 317--322
• Opis fizyczny: Bibliogr. 28 poz., rys., tab.

Twórcy

autor

Joshi S

• Doon University Department of Environmental Studies, School of Environment and Natural Resources Dehradun 248001 India

autor

Sharma A.

• K.L.D.A.V. (P.G.) College Department of Chemistry Roorkee 247667 India

Bibliografia

• [1] U. Borchard, J. Clin. Cardiol., 1, 5–9 (1998)
• [2] R. Mehvar and D.R. Brocks, J. Pharm. Pharmaceut. Sci., 4, 185–200 (2001)
• [3] A. Burger, Medicinal Chemistry — Part II, 3rd edn, Wiley Interscience, New York, 1970, p. 1246
• [4] M.H. Hyun, J. Sep. Sci., 29, 750–761 (2006)
• [5] A. Ghanem, H. Hoenen, and H.Y. Aboul-Enein, Talanta, 68, 602–609 (2006)
• [6] X. Zhang, J. Ouyang, W.R.G. Baryens, S. Zhae, Y. Yang, and G. Huang, J. Pharm. Biomed. Anal. 31, 1047–1057 (2003)
• [7] C. Vandenbosch, D.L. Massart, and W. Lindner, J. Pharm. Biomed. Anal., 10, 895–908 (1992)
• [8] B. Mistry, J.L. Leslie, and N.D. Eddington, J. Chromatogr. B, 758, 153–161 (2001)
• [9] M.I.R.M. Santoro, H.S. Cho, and E.R.M. Kedor-Hackmann, Drug Dev. Ind. Pharm., 27, 693–697 (2001)
• [10] A.M. Dyas, M.L. Robinson, and A.F. Fell, J. Chromatogr., 586, 351–355 (1991)
• [11] P.V. Petersen, J. Ekelund, L. Olsen, and S.V. Ovsen, J. Chromatogr. A, 757, 65–71 (1999)
• [12] A. Ceccato, Ph. Hubert, and J. Crommen, J. Chromatogr. A, 760, 193–203 (1997)
• [13] Y. Machida, H. Nishi, K. Nakamura, H. Nakai, and T. Sato, J. Chromatogr. A, 757, 73–79 (1997)
• [14] K. Krause, M. Girod, B. Chankvetadze, and G. Blaschke, J. Chromatogr. A, 837, 51–63 (1999)
• [15] D. Agbaba and B. Ivkovic, in: T. Kowalska and J. Sherma (Eds) Thin Layer Chromatography in Chiral Separations and Analysis, Taylor and Francis, New York, 2007, pp. 283–304
• [16] R. Bhushan and C. Agrawal, J. Planar Chromatogr., 21, 129–134 (2008)
• [17] R. Bhushan and D. Gupta, J. Planar Chromatogr., 19, 241–246 (2006)
• [18] R. Bhushan and M. Arora, Biomed. Chromatogr., 17, 226–230 (2003)
• [19] R. Bhushan and G.T. Thiongo, J. Chromatogr. B, 708, 330–334 (1998)
• [20] R. Bhushan and S. Tanwar, Biomed. Chromatogr., 22, 1028–1034 (2008)
• [21] M.B. Haung, J. Liq. Chromatogr. Relat. Technol., 20, 1507–1514 (1997)
• [22] R. Bhushan and C. Agrawal, J. Planar Chromatogr., 23, 7–13 (2010)
• [23] M.V. Rekharsky and Y. Inoue, Chem. Rev., 98, 1875–1917 (1998)
• [24] D.M. Radulovic, K.D. Karljikovic-Rajic, B.M. Lucic, and Z.B. Vujic, J. Pharm. Biomed. Anal., 24(5–6), 871–876 (2001)
• [25] A.F. Danil de Namor, R. Trabaulssi, and D.F.V. Lewis, J. Am. Chem. Soc., 112, 8442–8447 (1990)
• [26] B. Siegel and R. Breslow, J. Am. Chem. Soc., 97, 6869–6870 (1975)
• [27] Y. Sueishi, M. Kasahara, M. Inoue, and K.J. Matsueda, Inclusion Phenom. Macrocyclic Chem., 46, 71–75 (2003)
• [28] K.A. Cannors, Chem. Rev. 97, 1335–357 (1997)