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Tytuł artykułu

Preparation and characterization of pH-sensitive hydrogels from photo-crosslinked poly(ethylene glycol) diacrylate incorporating titanium dioxide

Identyfikatory
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
The purpose of the present investigation was to prepare pH-sensitive hydrogels from photo-crosslinked poly(ethylene glycol) diacrylate (PEG-DA). Rutile titanium dioxide (TiO2) was employed to modify the PEG-DA hydrogels. The rutile titanium dioxide (TiO2) nanoparticles were prepared by direct oxidation of titanium in the presence of polyethylene glycol (PEG) at high temperature. The nanoparticles were characterized by FT-IR, XRD and SEM. The influence of experimental conditions, such as pH, type and amount of photoinitiators on the release profiles of donepezil hydrochloride (active pharmaceutical ingredient for Alzheimer disease) from modified PEG-DA hydrogels, was investigated. The drug release processes were analyzed kinetically using zero-order, first-order, Hixson-Crowell and Peppas models.
Wydawca
Rocznik
Strony
443--449
Opis fizyczny
Bibliogr. 43 poz., rys., tab.
Twórcy
autor
  • Department of Chemical Engineering, Yıldız Technical University, 34210 Istanbul, Turkey
autor
  • Department of Chemical Engineering, Yıldız Technical University, 34210 Istanbul, Turkey
Bibliografia
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Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.baztech-79cc91f9-7096-4254-800a-05ae37e6ac42
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