Synthesis of novel 2-mercapto-4-(p-aminophenyl sulphonylamino)-6-(aryl)-pyrimidine-5-carboxamide derivatives via the Biginelli reaction

• Autorzy: Bhuva N. H. , Gothalia V. K. , Singala P. M. , Talpara P. K. , Faldu V. J. , Shah V. H.
• Języki publikacji: EN

Abstrakty

EN

Series of 2-mercapto-4-(p-aminophenylsulphonylamino)-6-(aryl)-pyrimidine-5-carboxamide Aa-h were synthesized via the biginelli condensation. 2-mercapto-4-amino-6-(aryl)-pyrimidine-5-carboxamide react with p-acetamidophenylsulphonylchloride in the presence of pyridine 2 to form 2-mercapto-4-(p-acetamidophenylsulphonylamino)-6-(aryl)-pyrimidine-5-carboxamide 3. It was treated with diluted HCl under reflux afforded 2-mercapto-4-(p-aminophenylsulphonylamino)-6-(aryl)-pyrimidine-5-carboxamide A _a-h. The newly synthesized compounds were characterized by elemental analyses, infrared (IR), ¹H NMR and ¹³ C NMR spectroscopic investigation.

Słowa kluczowe

EN

2-mercapto-4-(p-aminophenylsulphonylamino)-6-(aryl)-pyrimidine-5-carboxamide; Biginelli condensation

• Wydawca: Przedsiębiorstwo Wydawnictw Naukowych "DARWIN"
• Czasopismo: International Letters of Chemistry, Physics and Astronomy
• Rocznik: 2014
• Tom: Vol. 17, iss. 2
• Strony: 168--173
• Opis fizyczny: Bibliogr. 11 poz., wz.

Twórcy

autor

Bhuva N. H.

• Department of Chemistry, Saurashtra University, Rajkot - 360005, India

autor

Gothalia V. K.

• Department of Chemistry, Saurashtra University, Rajkot - 360005, India

autor

Singala P. M.

• Department of Chemistry, Saurashtra University, Rajkot - 360005, India

autor

Talpara P. K.

• Department of Chemistry, Saurashtra University, Rajkot - 360005, India

autor

Faldu V. J.

• Department of Chemistry, Saurashtra University, Rajkot - 360005, India

autor

Shah V. H.

• Department of Chemistry, Saurashtra University, Rajkot - 360005, India

Bibliografia

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