Degradation process of TMC-based polymers by mass spectrometry

• Autorzy: Jaworska J. , Kasperczyk J. , Maksymiak M. , Adamus G. , Dobrzyński P.
• Języki publikacji: EN

Abstrakty

EN

This paper presents results of degradation process investigations of resorbable poly(lactide-trimethylene carbonate). Materials used in this work were synthesized by the ring opening polymerization. Polymerization was carried out in bulk using Zr(acac)4 as initiator. The resulting copolymers were characterized by high resolution NMR spectroscopy. Then the copolymers were allowed to degrade in H2O for 53 weeks. These conditions allowed to analyze the degradation products of poly(lactide-trimethylene carbonate) and to determine the structure of oligomers using multi-stage mass spectrometry technique (ESI-MSn). ESI-MS analysis revealed the presence of two kinds of oligomers.

Słowa kluczowe

EN

polymers degradation; mass spectroscopy; oligomers

• Wydawca: Polish Society for Biomaterials in Cracow
• Czasopismo: Engineering of Biomaterials
• Rocznik: 2012
• Tom: Vol. 15, no. 113
• Strony: 26--28
• Opis fizyczny: Bibliogr. 4 poz., wykr.

Twórcy

autor

Jaworska J.

• Centre of Polymer and Carbon Materials, Skłodowskiej-Curie 34 St., 41-819 Zabrze, Poland

autor

Kasperczyk J.

• Centre of Polymer and Carbon Materials, Skłodowskiej-Curie 34 St., 41-819 Zabrze, Poland

autor

Maksymiak M.

• Centre of Polymer and Carbon Materials, Skłodowskiej-Curie 34 St., 41-819 Zabrze, Poland

autor

Adamus G.

• Centre of Polymer and Carbon Materials, Skłodowskiej-Curie 34 St., 41-819 Zabrze, Poland

autor

Dobrzyński P.

• Centre of Polymer and Carbon Materials, Skłodowskiej-Curie 34 St., 41-819 Zabrze, Poland

Bibliografia

• [1] Hua J., Gebarowska K., Dobrzynski P., Kasperczyk J., Wei J., Li S.: Influence of chain microstructure on the hydrolytic degradation of copolymers from 1,3-trimethylene carbonate and L- lactide, J. Polym. Sci. Part A: Polym Chem. 47 (2009) 3869-3879.
• [2] Dobrzynski P., Pastusiak M., Bero M.: Less toxic acetylaceto- nates as initiators of trimethylene carbonate and 2,2-dimethyltrimethylene carbonate ring opening polymerization, J. Polym. Sci. Part A: Polym Chem. 43 (2005) 1913-1922.
• [3] Pego P., Poot A.A., Grijpma D.W., Feijen J.: Physical properties of high weight 1,3-trimethylene carbonate and D,L-lactide copolymers, J. Mater. Sci.: Mater. Med, 14 (2003) 767-773.
• [4] Sharifpoor S., Amsden B.: In vitro release of a water-soluble agent from low viscosity biodegradable, injectable oligomers, Eur. J. Pharm. And Biopharm. 65 (2007) 336-345.

Uwagi

EN

Researches were conducted with financial support from project no. UDA-POIG.01.03.01-00-123/08-00