Engineered atenolol-glycoconjugates to target H9c2 cardiomyocyte cell lines

• Autorzy: Kumbha Smita Tukaram , Bhatia Manish Sudesh , Patil Shitalkumar Shivgonda

Identyfikatory

DOI

10.32933/ActaInnovations.43.3

• Języki publikacji: EN

Abstrakty

EN

Background: One of the most important fields of biomedical engineering study nowadays is targeted drug delivery to specific cells. A drug's therapeutic efficacy can be improved and optimised by tightly targeting it to a pathophysiologically essential tissue architecture. The goal of this research is to develop saccharide conjugates for the targeted delivery of Atenolol, a -blocker. Methods: Galactose (monosaccharide), pectin (polysaccharide), and chitosan were chosen as the saccharides (polysaccharide). By grafting Atenolol with the modified saccharides, the conjugates were created. Spectroscopic and thermal studies were used to describe the chemically changed saccharides conjugates. H9c2 cell lines were used to conduct drug release research and cellular uptake studies. To investigate cytotoxicity, a brine shrimp lethality test was done. Results: The outcomes exhibit that Atenolol-modified saccharide conjugates can productively convey the medication to the target. Conclusion: It can be inferred that the improvement of saccharide-drug conjugates can be a compelling methodology for targeting cardiovascular medication.

Słowa kluczowe

EN

glycoconjugates; atenolol; targeting

PL

glikokoniugaty; atenolol; targeting

• Wydawca: Centrum Badań i Innowacji Pro-Akademia ; Ukrainian Academy of Sciences - Research and Development Centre for Industrial Problems of Development
• Czasopismo: Acta Innovations
• Rocznik: 2022
• Tom: no. 43
• Strony: 36--43
• Opis fizyczny: Bibliogr. 17 poz.

Twórcy

autor

Kumbha Smita Tukaram

• Department of Pharmaceutical Chemistry, DSTS Mandal’s College of Pharmacy, Solapur, India

• https://orcid.org/0000-0002-3030-9477

autor

Bhatia Manish Sudesh

• Department of Pharmaceutical Chemistry, Bharati Vidyapeeth College of Pharmacy, Kolhapur, India

autor

Patil Shitalkumar Shivgonda

• Department of Pharmaceutics, Ashokrao Mane College of Pharmacy, Peth Vadgaon, India

Bibliografia

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Uwagi

Opracowanie rekordu ze środków MEiN, umowa nr SONP/SP/546092/2022 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2022-2023).