Preparation of chitosan/calcium phosphate based injectable system for guided bone regeneration and its properties investigation

• Autorzy: Bubak G. , Kowalczyk M. , Brynk T. , Bojar W. , Kucharska M. , Ciach T.
• Języki publikacji: EN

Abstrakty

EN

The main objective of the work was to design and fabricate an injectable biomaterial with osteoconductive properties that can be used in dental applications in peri-implant therapy concerning guided bone regeneration. For that purpose, a self-setting biomaterial consisting of chitosan/tricalcium phosphate microparticles and sodium alginate was formulated. The obtained material was characterized regarding microsphere and formed agglomerates morphology and microstructure. Physical properties, relating to setting time and mechanical properties, were also investigated. Finally, in vivo response to implanted biomaterial was studied on a rat model and compared with commercially available alloplastic material. The results showed that designed injectable biomaterial fulfi lled main requirements for guided bone regeneration application.

Słowa kluczowe

EN

chitosan; alginate; β-tricalcium phosphate; injectable systems; guided bone regeneration; in vivo studies; biomaterial

• Wydawca: Foundation for Young Scientists
• Czasopismo: Challenges of Modern Technology
• Rocznik: 2011
• Tom: Vol. 2, no. 4
• Strony: 21--26
• Opis fizyczny: Bibliogr. 7 poz., fot., rys., wykr.

Twórcy

autor

Bubak G.

• Biomedical Engineering Laboratory, Warsaw University of Technology, Faculty of Chemical and Process Engineering

autor

Kowalczyk M.

autor

Brynk T.

autor

Bojar W.

autor

Kucharska M.

autor

Ciach T.

Bibliografia

• [1] Reis L. R., and J. San Roman. Biodegradable systems in tissue engineering and regenerative medicine. CRC Press, 2005.
• [2] Meyer U., et al. Fundamentals of Tissue Engineering and Regenerative Medicine. Berlin: Springer, 2009.
• [3] Mazen, Almasri, and Mostafa Altalibi. ”Efficacy of reconstruction of alveolar bone using an alloplastic hydroxyapatite tricalcium phosphate graft under biodegradable chambers.” British Journal of Oral and Maxillofacial Surgery 2010. In Press. Corrected Proof. Available online 22 October 2010.
• [4] Friedman, Craig D. “Future directions in alloplastic materials for facial skeletal augmentation.” Facial Plastic Surgery Clinics of North America 10(2), 2002: 175--180.
• [5] Zhensheng, Lia, et al. “Chitosan-alginate hybrid scaff olds for bone tissue engineering.” Biomaterials 26(18), 2005:3919–1928.
• [6] Ravi Kumar, M.N.V, et al. ”Chitosan chemistry and pharmaceutical perspectives.” Chemical Review 104 (12), 2004: 6017–6084.
• [7] Augst, A.D., H.J. Kong, and D.J. Mooney. “Alginate Hydrogels as Biomaterials.” Macromolecular Bioscience 2006: 623–633.