Development of a rapid UPLC-MS/MS method for the determination of toddalolactone in mouse blood and its application in pharmacokinetics

• Autorzy: Zhou Jing , Wang Hongzhe , Miao Caiyun , Yao Yunxi , Ma Jianshe

Identyfikatory

DOI

10.1556/1326.2020.00864

• Języki publikacji: EN

Abstrakty

EN

A rapid and simple UPLC-MS/MS method was developed to determine toddalolactone in mouse blood and applied to measure the pharmacokinetics of toddalolactone in mice. Blood samples were first preprocessed by ethyl acetate liquid-liquid extraction. Oxypeucedanin hydrate (internal standard, IS) and toddalolactone were gradient eluted from a UPLC BEH C18 column using a mobile phase consisting of acetonitrile and water (0.1% formic acid). Using electrospray ionization (ESI) as the ionization source, multiple reaction monitoring was used to detect the precursor and product ions of m/z 309.2 and 205.2, respectively, for toddalolactone and of m/z 305.1 and 203.0 for IS, respectively, for quantitative detection. A calibration curve was run over the concentration range of 5–4,000 ng/mL (r > 0.995). The matrix effects ranged from 93.5 to 98.4%, and the recovery was higher than 77.3%. The precision was less than 13%, and the accuracy ranged from 90.9 to 108.4%. The developed UPLC-MS/MS method was successfully used for measuring the pharmacokinetics of toddalolactone in mice after oral (20 mg/kg) and intravenous administration (5 mg/kg), and the absolute bioavailability of toddalolactone was 22.4%.

Słowa kluczowe

EN

toddalolactone; mice; UPLC-MS/MS; determination; bioavailability

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2022
• Tom: Vol. 34, no. 1
• Strony: 18--23
• Opis fizyczny: Bibliogr. 17 poz., rys., tab.

Twórcy

autor

Zhou Jing

• Department of Pharmy, Ningbo Women & Children Hospital, Ningbo 315032, China

autor

Wang Hongzhe

• School of Basic Medicine, Wenzhou Medical University, Wenzhou 325035, China

autor

Miao Caiyun

• Department of Pharmy, Ningbo Women & Children Hospital, Ningbo 315032, China

autor

Yao Yunxi

• Department of Pharmy, Ningbo Women & Children Hospital, Ningbo 315032, China

autor

Ma Jianshe

• School of Basic Medicine, Wenzhou Medical University, Wenzhou 325035, China

• https://orcid.org/0000-0003-3432-3468

Bibliografia

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Uwagi

Opracowanie rekordu ze środków MEiN, umowa nr SONP/SP/546092/2022 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2022-2023).