Keram: a novel stand-alone application for correlated mutations identification and analysis

• Autorzy: Kuśka J. , Leluk J. , Lesyng B.
• Języki publikacji: EN

Abstrakty

EN

Keram is a stand-alone Windows 2000/XP/Vista application designed for the detection and analysis of the correlated mutations. Study of this phenomenon provides important information about protein structure stability factors as well as the formation of protein complexes. It is generally assumed that the mechanism of compensation explains the mutations that occur simultaneously. Keram is designed to detect the mutational correlations by comparative analysis of multiple sequence alignments. Additionally a three dimensional structure can be applied to calculate the distance between correlated positions in the protein molecule. Keram has been succesfully applied for the analysis of kinase subfamilies. The obtained data suggest that the mechanism of compensation does not explain utterly this phenomenon which seems to be much more complex and diverse. The residues that are detected as correlated are often placed at very distant positions of the protein structure, therefore the direct mutual interaction between them is impossible. We have detected not only correlated pairs, but also clusters of positions (even more than 10) that reveal correlated changeability.

Słowa kluczowe

EN

correlated mutations; multiple sequence alignment; protein-protein interaction

• Wydawca: Uniwersytet Jagielloński - Collegium Medicum ; Index Copernicus Sp. z o.o.
• Czasopismo: Bio-Algorithms and Med-Systems
• Rocznik: 2011
• Tom: Vol. 7, no. 1
• Strony: 71--76
• Opis fizyczny: Bibliogr. 19 poz., rys., tab.

Twórcy

autor

Kuśka J.

• Faculty of Biology, University of Warsaw, Poland
• CoE BioExploratorium, University of Warsaw, Poland

autor

Leluk J.

• Faculty of Biological Sciences, University of Zielona Góra, Poland
• CoE BioExploratorium, University of Warsaw, Poland

autor

Lesyng B.

• Faculty of Physics, University of Warsaw, Poland
• CoE BioExploratorium, University of Warsaw, Poland

Bibliografia

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