Synthesis, characterization, and molecular modeling of novel 1,3,4-oxadiazole derivatives of mefenamic acid

• Autorzy: Bhat Mashooq A. , Naglah Ahmed M. , Bakheit Ahmed Hassan , Al-Omar Mohamad A.

Identyfikatory

DOI

10.2478/pjct-2024-0016

• Języki publikacji: EN

Abstrakty

EN

A novel series of 1,3,4-oxadiazole derivatives of mefenamic acid was obtained by reacting hydrazones of mefenamic acid with anhydrous acetic anhydride. The mefenamic hydrazones were obtained by reacting different substituted aldehydes with mefenamic acid hydrazide. All the compounds were characterized by spectral data and elemental analysis. Molecular docking studies of all the compounds were performed against COX-1/COX-2 enzymes. Compound 4 and compound 10 were found to have the highest potential to bind with COX-1 while compound 3, compound 6, and compound 10 were found to have the highest potential to bind with COX-2 enzyme.

Słowa kluczowe

EN

Mefenamic acid; 1,3,4-Oxadiazoles; Hydrazones; Molecular docking; COX-1/COX-2 enzymes

• Wydawca: West Pomeranian University of Technology. Publishing House
• Czasopismo: Polish Journal of Chemical Technology
• Rocznik: 2024
• Tom: Vol. 26, nr 1
• Strony: 102--112
• Opis fizyczny: Bibliogr. 33 poz., rys., tab., wz.

Twórcy

autor

Bhat Mashooq A.

• Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University Riyadh, Saudi Arabia

autor

Naglah Ahmed M.

• Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University Riyadh, Saudi Arabia

autor

Bakheit Ahmed Hassan

• Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University Riyadh, Saudi Arabia

autor

Al-Omar Mohamad A.

• Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University Riyadh, Saudi Arabia

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