Therapeutic nail polishes based on ciclopirox

• Autorzy: Drabczyk Anna K. , Podobińska Patrycja , Mamica Agnieszka , Jaśkowska Jolanta

Identyfikatory

DOI

10.58332/scirad2023v2i4a04

• Języki publikacji: EN

Abstrakty

EN

The aim of the research work was to create a nail polish formulation that would carry the therapeutic substance ciclopirox (ciclopiroxolamine), a drug with an exceptionally broad spectrum of activity, exhibiting antifungal, antibacterial, bacteriostatic and anti-inflammatory activity. The experiments conducted proved that ciclopirox can not only be released from the developed formulations when applied directly to the plate, but can also be applied to nails covered with cosmetic varnish. The amount of released active ingredient reaches the minimum inhibitory concentration for cyclopirox in Candida spp. infection. Which suggests that the formulations would be effective for fungal infections. The best results in terms of film formation were obtained for formulations that were based on PVP. The highest released drug concentration occurred with formulation No. 3 and was 4.47 (mg/10ml) after 24 hours.

Słowa kluczowe

EN

therapeutic nail polishes; ciclopirox; Candida spp; onychomycosis

PL

lecznicze lakiery do paznokci; cyklopiroks; Candida spp; onychomikoza

• Wydawca: Radomskie Towarzystwo Naukowe
• Czasopismo: Scientiae Radices
• Rocznik: 2023
• Tom: Vol. 2, Iss. 4
• Strony: 347--358
• Opis fizyczny: Bibliogr. 22 poz., 1 rys., wykr.

Twórcy

autor

Drabczyk Anna K.

• Department of Organic Chemistry and Technology, Faculty of Chemical and Engineering and Technology, Cracow University of Technology, 24 Warszawska Street, 31-155 Cracow, Poland

autor

Podobińska Patrycja

• Department of Organic Chemistry and Technology, Faculty of Chemical and Engineering and Technology, Cracow University of Technology, 24 Warszawska Street, 31-155 Cracow, Poland

autor

Mamica Agnieszka

• Department of Organic Chemistry and Technology, Faculty of Chemical and Engineering and Technology, Cracow University of Technology, 24 Warszawska Street, 31-155 Cracow, Poland

autor

Jaśkowska Jolanta

• Department of Organic Chemistry and Technology, Faculty of Chemical and Engineering and Technology, Cracow University of Technology, 24 Warszawska Street, 31-155 Cracow, Poland

Bibliografia

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Uwagi

Opracowanie rekordu ze środków MNiSW, umowa nr SONP/SP/546092/2022 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2024).