Intraoperative imaging based on common-path time-domain reflectometry for brain tumor surgery

• Autorzy: Han Jae-Ho , Cha Jaepyeong

Identyfikatory

DOI

10.37190/oa200205

• Języki publikacji: EN

Abstrakty

EN

Minimally invasive intraoperative imaging plays a crucial role in delicate microsurgeries for precise operation monitoring in which fiber optic imaging can be considered as an endoscopy and surgical proximity guidance tool due to its compactness. This paper presents a near-infrared time-domain reflectometric common-path optical coherence tomography imaging technique using a bare-fiber probe mounted directly on a scanning galvanometer. The common-path setup allows the use of a freely adjustable optical path length and a disposable fiber probe, as well as eliminating the need for an additional dedicated reference optical path. Experimental results demonstrate clear discrimination between the brain tumor tissue and the normal tissue for mouse brains with the images acquired in real-time over a wide area. The proposed method enables real-time and in situ visualization of tumor resection for intraoperative imaging, and this study demonstrates the feasibility of its application to microsurgical interventions.

Słowa kluczowe

EN

optical coherence tomography; intraoperative imaging; reflectometry; endoscopy

• Wydawca: Oficyna Wydawnicza Politechniki Wrocławskiej
• Czasopismo: Optica Applicata
• Rocznik: 2020
• Tom: Vol. 50, nr 2
• Strony: 223--227
• Opis fizyczny: Bibliogr. 8 poz., rys.

Twórcy

autor

Han Jae-Ho

• Department of Brain and Cognitive Engineering, Korea University, 145 Anam Rd., Seoul 02841, South Korea

autor

Cha Jaepyeong

• Sheikh Zayed Institute for Pediatric Surgical Innovation, Children’s National Health System, Department of Pediatrics, George Washington University School of Medicine and Health Sciences, Washington, DC 20010 USA

Bibliografia

• [1] CHA J., BROCH A., MUDGE S. KIM K., NAMGOONG J., OH E., KIM P., Real-time, label-free, intraoperative visualization of peripheral nerves and micro-vasculatures using multimodal optical imaging techniques, Biomedical Optics Express 9(3), 2018, pp. 1097–1110, DOI:10.1364/BOE.9.001097.
• [2] GARZON-MUVDI T., KUT C., LI X., CHAICHANA K.L., Intraoperative imaging techniques for glioma surgery, Future Oncology 13(19), 2017, pp. 1731–1745, DOI:10.2217/fon-2017-0092.
• [3] KEATING J., TCHOU J., OKUSANYA O., FISHER C., BATISTE R., JIANG J., KENNEDY G., NIE S., SINGHAL S.,Identification of breast cancer margins using intraoperative near-infrared imaging, Journal of Surgical Oncology 113(5), 2016, pp. 508–514, DOI:10.1002/jso.24167.
• [4] LEE S., LEE C., VERKADE R., CHEON G.W., KANG J.U., Common-path all-fiber optical coherence tomography probe based on high-index elliptical epoxy-lensed fiber, Optical Engineering 58(2), 2019, article 026116, DOI:10.1117/1.OE.58.2.026116.
• [5] KATTA N., MCELROY A.B., ESTRADA A.D., MILNER T.E., Optical coherence tomography image-guided smart laser knife for surgery, Lasers in Surgery and Medicine 50(3), 2018, pp. 202–212, DOI:10.1002/lsm.22705.
• [6] LI X., HAN J.-H., LIU X., KANG J.U., Signal-to-noise ratio analysis of all-fiber common-path optical coherence tomography, Applied Optics 47(27), 2008, pp. 4833–4840, DOI:10.1364/AO.47.004833.
• [7] BÖHRINGER H.J., LANKENAU E., STELLMACHER F., REUSCHE E., HÜTTMANN G., GIESE A., Imaging of human brain tumor tissue by near-infrared laser coherence tomography, Acta Neurochirurgica 151(5), 2009, pp. 507–517, DOI:10.1007/s00701-009-0248-y.
• [8] CHEON G.W., HUANG Y., CHA J., GEHLBACH P.L., KANG J.U., Accurate real-time depth control for CP-SSOCT distal sensor based handheld microsurgery tools, Biomedical Optics Express 6(5), 2015, pp. 1942–1953, DOI:10.1364/BOE.6.001942.

Uwagi

Opracowanie rekordu ze środków MNiSW, umowa Nr 461252 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2020).