Study of the Properties and Cells Growth on Antibacterial Electrospun Polycaprolactone/Cefuroxime Scaffolds

• Autorzy: Mijovic Budimir , Zdraveva Emilija , Bajsić Emi Govorčin , Slivac Igor , Dekaris Iva , Grgurić Tamara Holjevac , Ferri Tea Zubin

Identyfikatory

DOI

10.2478/aut-2019-0036

• Języki publikacji: EN

Abstrakty

EN

Electrospun materials are good candidates for the design of tissue regeneration scaffolds as they can simulate the natural surroundings of tissue cells. The study proposes electrospun polycaprolactone (PCL)/cefuroxime (CFU) scaffolds for human cell culture and investigates the influence of the antibiotic content on scaffold morphology, thermal and mechanical properties. The increase in the CFU concentration resulted in the reduction of fiber diameter and number of deformations. It also influenced the reduction of scaffold thermal enthalpies and improved scaffold break strength. With regard to cell growth, the scaffolds showed precedence in greater colonization of the HeLa cells. Finally, these scaffolds showed compatibility with standard human cell lines, and thus they can be used for the repair of damaged tissues.

Słowa kluczowe

EN

electrospun; scaffolds; PCL; Cefuroxime; SEM; DSC; tensile behavior; human cell

PL

elektroprzędzenie; rusztowania; PCL; Cefuroksym; SEM; DSC; proces rozciągania; komórka ciała ludzkiego

• Wydawca: Lodz University of Technology, Faculty of Material Technologies and Textile Design
• Czasopismo: Autex Research Journal
• Rocznik: 2020
• Tom: Vol. 20, no. 3
• Strony: 312--318
• Opis fizyczny: Bibliogr. 20 poz.

Twórcy

autor

Mijovic Budimir

• University of Zagreb Faculty of Textile Technology, Department of Fundamental Natural and Engineering Sciences, Prilaz baruna Filipovića 28a, 10000 Zagreb, Croatia

autor

Zdraveva Emilija

• University of Zagreb Faculty of Textile Technology, Department of Fundamental Natural and Engineering Sciences, Prilaz baruna Filipovića 28a, 10000 Zagreb, Croatia

autor

Bajsić Emi Govorčin

• University of Zagreb Faculty of Chemical Engineering and Technology, Department of Polymer Engineering and Organic Chemical Technology, Marulićev Trg 19, 10000 Zagreb, Croatia

autor

Slivac Igor

• University of Zagreb Faculty of Food Technology and Biotechnology, Department of Biochemical Engineering, Pierottijeva ul. 6, 10000 Zagreb, Croatia

autor

Dekaris Iva

• Specialty Eye Hospital Svjetlost, Heinzelova ul. 39, 10000 Zagreb and Department of Ophthalmology Medical Faculty, University of Rijeka, Braće Branchetta 20/1, 51000 Rijeka, Croatia

autor

Grgurić Tamara Holjevac

• University of Zagreb, Faculty of Metallurgy, Department of Physical Metallurgy, Aleja narodnih heroja 3, Sisak, 44000, Croatia

autor

Ferri Tea Zubin

• Materials’ Research Center METRIS, Zagrebačka 30, 52100 Pula, Croatia

Bibliografia

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Uwagi

Opracowanie rekordu ze środków MNiSW, umowa Nr 461252 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2020).