Pharmacokinetics of tectorigenin, tectoridi, irigenin, and iridin in mouse blood after intravenous administration by UPLC-MS/MS

• Autorzy: Li Jianbo , Yao Yuqi , Zhou Minyue , Yu Zheng , Jin Yinan , Wang Xianqin

Identyfikatory

DOI

10.1556/1326.2021.00936

• Języki publikacji: EN

Abstrakty

EN

Tectorigenin, tectoridin, irigenin, and iridin are the four most predominant compounds present in She Gan. She Gan has been used in traditional Chinese medicine because of its anti-inflammatory, hep- atoprotective, anti-tumor, antioxidant, phytoestrogen-like properties. In this paper, a UPLC-MS/MS method was developed to measure the pharmacokinetics of tectorigenin, tectoridin, irigenin, iridin after intravenous administration in mice. A UPLC BEH C18 (50 mm × 2.1 mm, 1.7 µm particle size) chromatographic column was utilized for separation of the four target analytes and internal standard (IS), and the analysis of blood plasma samples; the mobile phase consisted of an acetonitrile-water (w/0.1% formic acid) gradient elution. Electron spray ionization (ESI) positive-ion mode and multiple reaction monitoring (MRM) mode was used for quantitative analysis of the analytes and internal standard. The four compounds were administered intravenously (sublingual) at doses of 5 mg/kg. After blood sam- pling, samples were processed and then analyzed by UPLC-MS/MS. The linearity of the method was robust over the concentration range of 2-5,000 ng/mL. The intra-day precision of the analysis was within 15%, the inter-day precision was within 12%, and the accuracy was between 92% and 110%. The recoveries were 65–68%, and the matrix effect was 93-109%. The established UPLC-MS/MS detection method was then successfully applied to study the pharmacokinetics of tectorigenin, tectoridin, irigenin, iridin in mice.

Słowa kluczowe

EN

tectorigenin; tectoridin; irigenin; iridin; UPLC-MS/MS; pharmacokinetics

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2022
• Tom: Vol. 34, no. 3
• Strony: 246--252
• Opis fizyczny: Bibliogr. 25 poz., rys., wykr.

Twórcy

autor

Li Jianbo

• The Second Affiliated Hospital Zhejiang University School of Medicine Yuhang Campus, Hangzhou, China

autor

Yao Yuqi

• Analytical and Testing Centre, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China

autor

Zhou Minyue

• Analytical and Testing Centre, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China

autor

Yu Zheng

• Analytical and Testing Centre, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China

autor

Jin Yinan

• Analytical and Testing Centre, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China

autor

Wang Xianqin

• Analytical and Testing Centre, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China

• https://orcid.org/0000-0002-9821-3770

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