An HPLC method for the determination of moxifloxacin in breast milk by fluorimetric detection with precolumn derivatization

• Autorzy: Tekkeli S. E. , Gazioglu I. , Kiziltas M. V.

Identyfikatory

DOI

10.1556/1326.2017.29.1.4

• Języki publikacji: EN

Abstrakty

EN

A new, sensitive, and selective high-performance liquid chromatography (HPLC) method with fluorimetric detection was developed for the determination of moxifloxacin (MOX) in human breast milk. MOX was precolumn derivatized with fluorescamine; the fluorescent derivative was separated on an RP C18 column using a mobile phase composed of acetonitrile–10 mM orthophosphoric acid by isocratic elution with flow rate of 0.5 mL min ^-1. The method was based on the measurement of the derivative using fluorescence detection at 481 nm with excitation at 351 nm. The calibration curve was linear over the range of 1–40 μg Ml ^-1. Limit of detection (LOD) and limit of quantitation (LOQ) were found to be 0.3 and 1 μg Ml ^-1, respectively. Intra-day and interday repeatabilities were less than 3.15%.

Słowa kluczowe

EN

breast milk; fluorescamine; fluorimetric detection; moxifloxacin; liquid chromatography; precolumn derivatization

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2017
• Tom: Vol. 29, no. 1
• Strony: 57--65
• Opis fizyczny: Bibliogr. 20 poz., rys., tab.

Twórcy

autor

Tekkeli S. E.

• Bezmialem Vakif University, Faculty of Pharmacy, Department of Analytical Chemistry, 34093 Fatih, Istanbul, Turkey

autor

Gazioglu I.

• Bezmialem Vakif University, Faculty of Pharmacy, Department of Analytical Chemistry, 34093 Fatih, Istanbul, Turkey

autor

Kiziltas M. V.

• Bezmialem Vakif University, Faculty of Pharmacy, Department of Analytical Chemistry, 34093 Fatih, Istanbul, Turkey

Bibliografia

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Uwagi

PL

Opracowanie ze środków MNiSW w ramach umowy 812/P-DUN/2016 na działalność upowszechniającą naukę (zadania 2017).