The effect of titanium dioxide addition on physical and biological properties of Na2O-B2O3-P2O5 and CaO-Na2O-P2O5 glasses

• Autorzy: Kalwasińska O. , Gajc M. , Kłos A. , Orliński K. , Pawlak D. A. , Krok-Borkowicz M. , Rumian Ł. , Pietryga K. , Reczyńska K. , Pamuła E.
• Języki publikacji: EN

Abstrakty

EN

Two types of phosphate glasses 50Na2O-20B2O3-30P2O5 (NBP) and 30CaO-20Na2O-50P2O5 (CNP) with different content of TiO2 (0, 3 and 5 mol%) have been prepared by melt-quenching process. TiO2 was added to increase glass network stability. Physical properties of glasses were investigated by density measurements, differential scanning calorimetry and degradation in phosphate buffered saline (PBS). Biological performance of glasses in a direct contact with osteoblast-like MG-63 cells was analysed with the use of resazurin test and live-dead staining. The results show that TiO2 addition increased density, glass transition temperature (Tg) and melting temperature (Tm) of both types of glasses. In the case of NBP glasses presence of TiO2 resulted in their fast degradation in PBS and acidification of cell culture medium. As a consequence such glasses did not support cell adhesion and growth, but they can be considered for e.g. drug delivery systems. On the other hand addition of TiO2 to CNP glasses resulted in enhanced cell adhesion and viability. Particularly positive results were found for CNP glass containing 5% TiO2, so it can be a good candidate as a scaffold material for bone tissue engineering.

Słowa kluczowe

EN

phosphate glasses; bioactive glasses; titanium dioxide; tissue engineering

• Wydawca: Polish Society for Biomaterials in Cracow
• Czasopismo: Engineering of Biomaterials
• Rocznik: 2016
• Tom: Vol. 19, no. 134
• Strony: 2--7
• Opis fizyczny: Bibliogr. 19 poz., tab., wykr., zdj.

Twórcy

autor

Kalwasińska O.

• Warsaw University of Technology, Faculty of Materials Science and Engineering, Wołoska 141, 02-507 Warsaw, Poland

autor

Gajc M.

• Institute of Electronic Materials Technology, Wólczyńska 133, 01-919 Warsaw, Poland

autor

Kłos A.

• Institute of Electronic Materials Technology, Wólczyńska 133, 01-919 Warsaw, Poland

autor

Orliński K.

• Institute of Electronic Materials Technology, Wólczyńska 133, 01-919 Warsaw, Poland

autor

Pawlak D. A.

• Institute of Electronic Materials Technology, Wólczyńska 133, 01-919 Warsaw, Poland
• Centre of New Technologies, Banacha 2C, 02-097 Warsaw, Poland

autor

Krok-Borkowicz M.

• AGH University of Science and Technology, Faculty of Materials Science and Ceramics, Department of Biomaterials, al. A. Mickiewicza 30, 30-059 Krakow, Poland

autor

Rumian Ł.

• AGH University of Science and Technology, Faculty of Materials Science and Ceramics, Department of Biomaterials, al. A. Mickiewicza 30, 30-059 Krakow, Poland

autor

Pietryga K.

• AGH University of Science and Technology, Faculty of Materials Science and Ceramics, Department of Biomaterials, al. A. Mickiewicza 30, 30-059 Krakow, Poland

autor

Reczyńska K.

• AGH University of Science and Technology, Faculty of Materials Science and Ceramics, Department of Biomaterials, al. A. Mickiewicza 30, 30-059 Krakow, Poland

autor

Pamuła E.

• AGH University of Science and Technology, Faculty of Materials Science and Ceramics, Department of Biomaterials, al. A. Mickiewicza 30, 30-059 Krakow, Poland

Bibliografia

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Uwagi

Opracowanie ze środków MNiSW w ramach umowy 812/P-DUN/2016 na działalność upowszechniającą naukę.