Generation and measurement of acoustic streaming in limited space

• Autorzy: Secomski W. , Nowicki A.
• Języki publikacji: EN

Abstrakty

EN

The aim of this work was to use the streaming phenomena to assist clot dissolution in blood vessel. Such treatment is called sonothrombolysis. Acoustic streaming is a steady flow in a fluid driven by the acoustic wave propagating in a lossy medium. It is a non-linear effect and it depends on ultrasound intensity, and sound absorption in the media. The source of ultrasound was a flat piezoceramic disc generating long pulses at 1 MHz frequency and 0.2 W/cm2 ITA acoustical intensity. The streaming was generated in a vessel simulating free space, and next repeated in a multi-well cell culture plate, and in the limited space inside the 8 mm diameter silicone tube positioned perpendicular to the ultrasonic beam. The tube was filled with a mixture of water, glycerol, and starch, so with acoustic properties similar to blood. The streaming velocity was recorded either by the Siemens Acuson Antares ultrasonic scanner operating in the color Doppler mode at 8.9 MHz, or by the custom built 20 MHz pulsed Doppler flowmeter. The results obtained using both systems were very similar. The recorded streaming velocities were 3.2 cm/s, 6.1 cm/s and 0.3 cm/s, respectively. They were an order of magnitude smaller than that calculated theoretically. However, the results obtained confirm existence of streaming, even very close to the source, in the limited space. This effect will be explored in in-vitro experiments of blood clot dissolution within the tube simulating a blood vessel.

Słowa kluczowe

EN

ultrasound; radiation force; blood; thrombolysis

• Wydawca: Polskie Towarzystwo Akustyczne. Oddział Gdański
• Czasopismo: Hydroacoustics
• Rocznik: 2016
• Tom: Vol. 19
• Strony: 361--368
• Opis fizyczny: Bibliogr. 7 poz., rys.

Twórcy

autor

Secomski W.

• Department of Ultrasound, Institute of Fundamental Technological Research Polish Academy of Sciences Pawińskiego 5B, 02-106 Warszawa, Poland

autor

Nowicki A.

• Department of Ultrasound, Institute of Fundamental Technological Research Polish Academy of Sciences Pawińskiego 5B, 02-106 Warszawa, Poland

Bibliografia

• [1] W.L. Nyborg, Acoustic streaming, in W.P. Mason, ed., Physical acoustics, IIB, Academic Press, 265-331, New York 1965.
• [2] S. Tjotta, On some non-linear effects in sound fields with special emphasis on generation of vorticity and the formation of streaming patterns, Arch.Math. Naturvidensk., 55, 1-68, 1959.
• [3] A. Nowicki, W. Secomski, J. Wojcik, Acoustic streaming: Comparison of lowamplitude linear model with streaming velocities measured by 32-MHz Doppler, Ultrasound in Med. & Biol. 23 (5): 783-791, 1997.
• [4] A.V. Alexandrov, Ultrasound-enhanced thrombolysis for stroke: clinical significance, European Journal of Ultrasound, 16 (1–2): 131–140, 2002.
• [5] T. Kujawska, W. Secomski, K. Bilmin, A. Nowicki, P. Grieb, Impact of thermal effects induced by ultrasound on viability of rat C6 glioma cells, Ultrasonics, 54 (5): 1366- 1372, 2014.
• [6] T. Yoshida, K. Tanaka, K. Sato, T. Kondo, K. Yasukawa, N. Miyamoto, M. Taniguchi, Blood-Mimicking Fluid for the Doppler Test Objects of Medical Diagnostic Instruments, 2012 IEEE International Ultrasonics Symposium, DOI: 10.1109/ULTSYM.2012.0403, 1-4, 2012.
• [7] G. Bambi, T. Morganti, S. Ricci, E. Boni, F. Guidi, C. Palombo, P. Tortoli, A novel ultrasound instrument for investigation of arterial mechanics, Ultrasonics 42 (1-9): 731- 737, 2004.

Uwagi

PL

Opracowanie ze środków MNiSW w ramach umowy 812/P-DUN/2016 na działalność upowszechniającą naukę (zadania 2017)