UPLC–MS/MS simultaneous determination of methamphetamine, amphetamine, morphine, monoacetylmorphine, ketamine, norketamine, MDMA, and MDA in hair

• Autorzy: Chen Siyuan , Ma Jianshe , Wang Xianqin , Geng Peiwu

Identyfikatory

DOI

10.1556/1326.2019.00615

• Języki publikacji: EN

Abstrakty

EN

Hair is a stable specimen and has a longer detection window (from weeks to months) than blood and urine. Through the analysis of hair, the long-term information of the drug use of the identified person could be explored. Our work is to establish an ultra-performance liquid chromatography–tandem mass spectroscopy (UPLC–MS/MS) method for simultaneous determination of methamphetamine, amphetamine, morphine, monoacetylmorphine, ketamine, norketamine, 3,4-methylenedioxymethamphetamine (MDMA), and 3,4-methylenedioxyamphetamine (MDA) in hair. Methoxyphenamine was used as an internal standard. The chromatographic separation was performed on a UPLC ethylene bridged hybrid (BEH) C18 (2.1 mm × 50 mm, 1.7 μm) column using a mobile phase of acetonitrile–water with 10 mmol/L ammonium acetate solution which containing 0.05% ammonium hydroxide. The multiple reaction monitoring in positive electrospray ionization was used for quantitative determination. The intra-day and inter-day precisions (relative standard deviation [RSD]) were below 15%. The accuracy ranged between 85.5% and 110.4%, the average recovery rate was above 72.9%, and the matrix effect ranged between 92.7% and 109.2%. Standard curves were in the range of 0.05–5.0 ng/mg, and the correlation coefficients were greater than 0.995. The established UPLC–MS/MS method was applied to analyze the hair samples successfully.

Słowa kluczowe

EN

UPLC–MS/MS; methamphetamine; amphetamine; morphine; monoacetymorphine; ketamine

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2020
• Tom: Vol. 32, no. 2
• Strony: 145--148
• Opis fizyczny: Bibliogr. 33 poz., rys.

Twórcy

autor

Chen Siyuan

• Wenzhou Medical University, Wenzhou 325035, China
• Wenzhou Medical University, Wenzhou 325035, China

autor

Ma Jianshe

• Wenzhou Medical University, Wenzhou 325035, China

autor

Wang Xianqin

• Wenzhou Medical University, Wenzhou 325035, China
• Wenzhou Medical University, Wenzhou 325035, China

autor

Geng Peiwu

• The People's Hospital of Lishui, Lishui 323000, China

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Uwagi

PL

Opracowanie rekordu ze środków MNiSW, umowa Nr 461252 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2020).