Harnessing biopolyesters in the design of functional materials for biomedical applications

• Autorzy: Renard E. , Babinot J. , Lemechko P. , Ramier J. , Vergnol G. , Versace D. L. , Grande D. , Langlois V.
• Języki publikacji: EN

Abstrakty

EN

The present contribution illustrates the versatility of poly(3-hydroxyalkanoate)s (PHAs) in the design of a wide variety of biodegradable and/or biocompatible macromolecular architectures with controlled degradability. Firstly, functionalized PHAs were prepared from unsaturated PHAs. Pendant double bonds have been turned into carboxyl, hydroxyl, alkyne or epoxy groups. These reactive functions were used for further grafting hydrolyzable polylactide (PLA) or poly(ε-caprolactone) (PCL) as well as hydrophilic poly(ethylene glycol) (PEG). Additionally, block copolymers with a PLA, PCL or PEG segment have been prepared by ring-opening polymerization or "click" chemistry from a PHA oligomeric macroinitiator. Functional PHAs represent biodegradable aliphatic polyesters with many possibilities to tune physico-chemical characteristics, such as hydrophilicity and degradation rate, thus making the resulting materials suitable as devices for drug delivery or as scaffolds for tissue engineering. Herein, we address the recent trends in the synthesis of these polymeric materials and their applications in controlled drug delivery and tissue engineering.

Słowa kluczowe

EN

poly(3-hydroxyalkanoate)s; block and graft copolymers; drug delivery; tissue engineering

• Wydawca: Polish Society for Biomaterials in Cracow
• Czasopismo: Engineering of Biomaterials
• Rocznik: 2012
• Tom: Vol. 15, no. 113
• Strony: 19--22
• Opis fizyczny: Bibliogr. 12 poz., rys., wykr.

Twórcy

autor

Renard E.

• Institut de Chimie et des Materiaux Paris Est, UMR 7182 CNRS- Universite Paris Est Creteil, 94320 Thiais, France

autor

Babinot J.

• Institut de Chimie et des Materiaux Paris Est, UMR 7182 CNRS- Universite Paris Est Creteil, 94320 Thiais, France

autor

Lemechko P.

• Institut de Chimie et des Materiaux Paris Est, UMR 7182 CNRS- Universite Paris Est Creteil, 94320 Thiais, France

autor

Ramier J.

• Institut de Chimie et des Materiaux Paris Est, UMR 7182 CNRS- Universite Paris Est Creteil, 94320 Thiais, France

autor

Vergnol G.

• Institut de Chimie et des Materiaux Paris Est, UMR 7182 CNRS- Universite Paris Est Creteil, 94320 Thiais, France

autor

Versace D. L.

• Institut de Chimie et des Materiaux Paris Est, UMR 7182 CNRS- Universite Paris Est Creteil, 94320 Thiais, France

autor

Grande D.

• Institut de Chimie et des Materiaux Paris Est, UMR 7182 CNRS- Universite Paris Est Creteil, 94320 Thiais, France

autor

Langlois V.

• Institut de Chimie et des Materiaux Paris Est, UMR 7182 CNRS- Universite Paris Est Creteil, 94320 Thiais, France

Bibliografia

• [1] Lenz, R. W.; Marchessault, R. H. Biomacromolecules 2005, 6, 1.
• [2] Chen, G. Q. Chem. Soc. Rev. 2009, 38, 2434.
• [3] Lee, S. Y. Biotechnol. Bioeng. 1996, 49, 1.
• [4] Timbart, L.; Renard, E.; Tessier, M.; Langlois, V. Biomacromolecules 2007, 8, 1255.
• [5] Kurth, N.; Renard, E.; Brachet, F.; Robic, D.; Guerin, P.; Bourbouze, R. Polymer 2002, 43, 1095.
• [6] Babinot, J.; Renard, E.; Langlois, V. Macromol. Rapid Commun. 31, 619.
• [7] Babinot, J.; Renard, E.; Langlois, V. Macromol. Chem. Phys. 212, 278.
• [8] Renard, E.; Poux, A.; Timbart, L.; Langlois, V.; Guerin, P. Biomacromolecules 2005, 6, 891.
• [9] Grande, D.; Renard, E.; Langlois, V.; Rohman, G.; Timbart, L.; Guerin, P. In Degradable Polymers and Materials - Principles and Practice; Khemani, K., Scholz, C., Eds.; ACS Symposium Series 939; American Chemical Society: Washington, DC, 2006; chap. 9, pp. 140-155.
• [10] Bear, M. M.; Leboucher-Durand, M. A.; Langlois, V.; Lenz, R. W.; Goodwin, S.; Guerin, P. React. Funct. Polym. 1997, 34, 65.
• [11] Renard, E.; Timbart, L.; Vergnol, G.; Langlois V. J. Appl. Polym. Sci. 2010, 117.
• [12] Renard, E.; Vergnol, G.; Langlois,V. IRBM 2011,32, 214.