IR and ¹H NMR spectral studies of some 2-Amino-4-isopropyl-6-methoxy-N-phenylpyrimidine-5-carboxamides: Assessment of substituent effects

• Autorzy: Arulkumaran R. , Sundararajan R. , Manikandan V. , Sathiyendiran V. , Pazhamalai S. , Thirunarayanan G.
• Języki publikacji: EN

Abstrakty

EN

A series of 2-Amino-4-isopropyl-6-methoxy-N-phenylpyrimidine-5-carboxamide compounds have been synthesized from various substituted dithioacetal and guanidine. The purities of these compounds were checked by their physical constants, UV, IR, NMR and MASS spectral data. The IR and ¹HNMR spectral data of these compounds have been correlated with Hammett sigma constants, F and R parameters using single and multi-linear regression analysis. From the results of statistical analysis, the effects of substituents on the spectral group frequencies have been discussed.

Słowa kluczowe

EN

2-Amino-4-isopropyl-6-methoxy-N-phenylpyrimidine-5-carboxamides; IR spectra; NMR spectra; substituent effects

• Wydawca: Przedsiębiorstwo Wydawnictw Naukowych "DARWIN"
• Czasopismo: International Letters of Chemistry, Physics and Astronomy
• Rocznik: 2014
• Tom: Vol. 19, iss. 1
• Strony: 15--25
• Opis fizyczny: Bibliogr. 40 poz., rys., tab., wz.

Twórcy

autor

Arulkumaran R.

• PG & Research Department of Chemistry, Government Arts College, C-Mutlur, Chidambaram - 608 102, India

autor

Sundararajan R.

• PG & Research Department of Chemistry, Government Arts College, C-Mutlur, Chidambaram - 608 102, India

autor

Manikandan V.

• PG & Research Department of Chemistry, Government Arts College, C-Mutlur, Chidambaram - 608 102, India

autor

Sathiyendiran V.

• Department of Chemistry, Sourashtra College, Madurai - 625 004, India

autor

Pazhamalai S.

• DDE wing of Chemistry, Annamalai University, Annamalainagar - 608 002, India

autor

Thirunarayanan G.

• Department of Chemistry, Annamalai University, Annamalainagar - 608 002, India

Bibliografia

• [1] T. Panneer Selvam, C. Richa James, P. Vijaysarathy Dniandev, S. Karyn Valzita, Res. in Phar. 2(4) (2012) 01-09.
• [2] L. W. Hertel, G. B. Boder, J. S. Kroin, et al., Cancer Res. 50 (1990) 4417- 4422.
• [3] K. Desai, R. Patel, K. Chikhalia, J. Ind. Chem. 45(B) (2006) 773-778.
• [4] A. E. Amr, M. S. Nermien, M. M. Abdulla, Monatsh. Chem., 138 (2007) 699-707.
• [5] N. Fujiwara, T. Nakajima, Y. Ueda, H. Fujita, H. Kawakami, Bioorg. Med. Chem. 16 (2008) 9804-9816.
• [6] L. Ballell, R. A. Field, G. A. C. Chung, R. J. Young, Bioorg. Med. Chem. Lett. 17 (2007) 1736-1740.
• [7] E. Wagner, K. Al-Kadasi, M. Zimecki, W. Sawka-Dobrowolska, Eur. J. Med. Chem. 43 (2008) 2498-2504.
• [8] K. Gorlitzer, S. Herbig, R. D. Walter, Pharmazie. 52 (1997) 670-672.
• [9] W. ShenJeu, L. Cheng Tsung, T. Lo Ti, W. Jing Ru, K. Hrogn Huey. W. JihPyang, and L. C. Nan, Eur. J. Med. Chem. 40 (2005) 103-112
• [10] Z. Machon, J. Cieplik, Synthesis. 2 (1986) 142-144.
• [11] Z. Machon, J. Cieplik, J. Pharmacol. Pharm. 40 (1988) 201-208.
• [12] N. R. Mohamed, M. M. El-Saidi, Y. M. Ali, M. H. Elnagdi, Sci. Pharm. 75 (2007) 9-28.
• [13] J. Cieplik, Z. MachoN, M. Zimecki, Z. Wieczorek, Arch. Immunol. Ther. Exp. 41(1993)11-15.
• [14] J. Cieplik, Z. MachoN, M. Zimecki, Z. Wieczorek, Farmaco. 50 (1993) 131-132
• [15] J. Pluta, M. Flendrich, J. Cieplik, Boll. Chim. Farm. 135 (1996) 459-464
• [16] Y. A. Mostafa, M. A. Husein, A. A. Radwan, A. H. Kfafy, Arch. Pharm. Res. Soc. Korea. 31 (2008) 279-293
• [17] G. T. Kim, R. J. Ryu, S. Lee Ch, H. Youn, Y. R. Cho, H. Y. Joo, J. Antibio. Jap. Res. (2004) 468-471.
• [18] J. Cieplik, J. Pluta, A. Meler, Arch. Pharm. Pharm. Med. Chem. 330 (1997) 237-241.
• [19] N. S. Habib, R. Soliman, A. A. El-Tombary, S. A. El-Hawash, O. G. Shaaban, Arch. Pharm. Res. Soc. Korea. 30 (2007) 1511-1520.
• [20] J. Cieplik, J. Pluta, O. Gubrynowicz, Sci. Pharm. 68 (2000) 333-336.
• [21] J. Cieplik , M. Raginia, J. Pluta, O. Gubrynowicz, I. Bryndal, T. Lis, Acta. Pol. Pharm. Drug. Res. 65 (2008) 427-434.
• [22] Z. Macho, J. Cieplik, Eur. J. Med. Chem., Chim. Ther. 19 (1984) 359-363.
• [23] H. R. Khunt, P. P. Pipaliya, S. M. Ghelani, J. S. Babariya, Y. T. Naliapara, International Letters of Chemistry, Physics and Astronomy 5 (2014) 134-121.
• [24] W.P. Hays, C. J.Timmons., Spectrochim. Acta. 24A (1968) 323-334.
• [25] C.G. Swain, E. C. Lupton Jr., J. Am. Chem. Soc. 90 (1968) 4328-4337.
• [26] R. Ranganathan, R. Arulkumaran, D. Kamalakkannan, G. Vanangamudi, G. Thirunarayanan., IUP J. Chem. 4(2) (2011) 60-70.
• [27] K. Sathiyamoorthi, V. Mala, R. Suresh, S. P. Sakthinathan, D. Kamalakkannan, K. Ranganathan, R. Arulkumaran, R. Sundararajan, S. Vijayakumar, G. Vanangamudi, G. Thirunarayanan, International Letters of Chemistry, Physics and Astronomy 7 (2013) 102-119.
• [28] V. Mala, K. Sathiyamoorthi, S. P. Sakthinathan, D. Kamalakkannan, R. Suresh, G. Vanangamudi, G. Thirunarayanan, Q. Science Connect. (2013) 7, DOI:http://dx.doi.org/ 10.5339/ connect.2013.7
• [29] S. P. Sakthinathan, R. Suresh, V. Mala, K. Sathiyamoorthi, D. Kamalakkannan, K. Ranganathan, R. Arulkumaran, S. Vijayakumar, R. Sundararajan, G. Vanangamudi, G. Thirunarayanan, International Letters of Chemistry, Physics and Astronomy 6 (2013) 77-90.
• [30] R. Suresh, D. Kamalakkannan, K. Ranganathan, R. Arulkumaran, R. Sundararajan, S.P. Sakthinathan, S. Vijayakumar, K. Sathiyamoorthi, V. Mala, G. Vanangamudi, K. Thirumurthy, P. Mayavel, G. Thirunarayanan, Spectrochim. Acta Part A.,101 (2013) 239-248.
• [31] K. Sathiyamoorthi, V. Mala, S.P. Sakthinathan, D. Kamalakkannan, R. Suresh, G. Vanangamudi , G. Thirunarayanan., Spectrochim. Acta Part A, 112 (2013) 245-256
• [32] P. Janaki, K. G Sekar, G. Thirunarayanan., Organic Chem: An Indian J., 9 (2013) 68-80.
• [33] R. Arulkumaran, R. Sundararajan, G. Vanangamudi, M .Subramanian, K. Ravi, V. Sathiyendiran, S. Srinivasan, G. Thirunarayanan., IUP J. Chem., 3 (2010) 82-98.
• [34] S. Vijayakumar, R. Arulkumaran, R. Sundararajan, S. P. Sakthinathan, R. Suresh, D. Kamalakkannan, K. Ranganathan, K. Sathiyamoorthi, V. Mala, G. Vanangamudi, G. Thirunarayanan, International Letters of Chemistry, Physics and Astronomy 9 (2013) 68-86.
• [35] G. Thirunarayanan, K. G. Sekar, International Letters of Chemistry, Physics and Astronomy 17(2)(2014) 193-200.
• [36] G. Thirunarayanan, K. G. Sekar, International Letters of Chemistry, Physics and Astronomy 17(1) (2014) 10-20
• [37] G. Thirunarayanan, K.G. Sekar, R. Lakshmi Narayanan, International Letters of Chemistry, Physics and Astronomy 13(1) (2014) 88-94.
• [38] P. Mayavel, K. Thirumurthy, S. Dinesh Kumar, G. Thirunarayanan, Q-Science Connect. (2014). DOI: http://dx.doi.org/10.5339/connect.2014.10
• [39] G. Thirunarayanan, K. G. Sekar, J. Taibah Univ. Sci. 8(2014) 124-136.
• [40] V. Sathiyendiran, K. G. Sekar, G. Thirunarayanan, R. Arulkumaran, R. Sundararajan, D. Kamalakkannan, R. Suresh, V. Manikanadan, R. Vijayakumar, G. Vanangamudi, International Letters of Chemistry, Physics and Astronomy 11(1) (2014) 33-43.