New LC–UV methods for pharmaceutical analysis of novel anti-diabetic combinations

• Autorzy: Abdel-Ghany M. F. , Abdel-Aziz O. , Ayad M. F. , Tadros M. M.

Identyfikatory

DOI

10.1556/1326.2016.00089

• Języki publikacji: EN

Abstrakty

EN

New, simple, selective, and sensitive liquid chromatography–ultraviolet (LC–UV) methods have been developed and subsequently validated for simultaneous determination of linagliptin–empagliflozin combination and simultaneous determination of alogliptin benzoate–pioglitazone hydrochloride combination. Linearity was found to be acceptable over the concentration ranges of 2–50 μg Ml^-1, 4–100 μg Ml^-1, 0.5–25 μg Ml^-1, and 1–25 μg Ml^-1 for linagliptin (LNG), empagliflozin (EMG), alogliptin (ALG), and pioglitazone (PGN), respectively. All the methods were applied successfully to the analysis of the pharmaceutical dosage forms. The optimized methods were validated and proved to be robust and accurate for the quality control of the mentioned drugs in their different pharmaceutical dosage forms.

Słowa kluczowe

EN

linagliptin; empagliflozin; alogliptin benzoate; piogliatazone hydrochloride; LC–UV

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2017
• Tom: Vol. 29, no. 4
• Strony: 448--452
• Opis fizyczny: Bibliogr. 14 poz., rys.

Twórcy

autor

Abdel-Ghany M. F.

• Analytical Chemistry Department, Faculty of Pharmacy, Ain Shams University, Abbassia, Cairo 11566, Egypt

autor

Abdel-Aziz O.

• Analytical Chemistry Department, Faculty of Pharmacy, Ain Shams University, Abbassia, Cairo 11566, Egypt

autor

Ayad M. F.

• Analytical Chemistry Department, Faculty of Pharmacy, Ain Shams University, Abbassia, Cairo 11566, Egypt

autor

Tadros M. M.

• Analytical Chemistry Department, Faculty of Pharmacy, Ain Shams University, Abbassia, Cairo 11566, Egypt

Bibliografia

• [1] Minze, M. G. ; Koffarnus, R. L. ; Bailey, T. A. ; Diec, S. ; Edwards, K. L. Expert Rev. Endocrinol. Metab. 2015 , 10 , 645 – 661
• [2] Baetta, R. ; Corsini, A. Drugs 2011 , 71 , 1441 – 1467
• [3] Carpino, P. A. ; Hepworth, D. Annu. Rep. Med. Chem. 2012 , 47 , 177 – 192
• [4] Ayoub, B. M. RSC Adv. 2015 , 5 , 95703 – 95709
• [5] Padmaja, N. ; Veerabhadram G. Pharm. Lett. 2015 , 7 , 306 – 312
• [6] Ayoub, B. M. Spectrochim. Acta, Part A 2016 , 168 , 118 – 122
• [7] Neelima, B. ; Kumar, P. R. ; Bindu, V. H. ; Prasad, Y. R. Int. J. Pharm. 2014 , 4 , 458 – 464 .
• [8] Kashyap, R. ; Srinivasa, U. Int. J. Curr. Res. 2014 , 6 , 10201 – 10207
• [9] Ahmed, M. ; Anusha, M. ; Satishkumar, S. A. ; Kuppast, I. J. ; Siddalingaswamy, M. S. ; Ravi, M. C. World J. Pharm. Pharm. Sci. 2014 , 4 , 863 – 874
• [10] M. M. Mabrouk , S. F. Hammad , F. R. Mansour , M. M. Amer , Pharm. Sin. 2016 , 7 , 32 – 40
• [11] Kashyap, R. ; Srinivasa, U. Int. J. Pharm. Pharm. Sci. 2014 , 6 , 730 – 738
• [12] El-Bagary, R. I. ; Elkady, E. F. ; Ayoub, B. M. Int. J. Biomed. Sci. 2012 , 8 , 209 – 214
• [13] Ayoub, B. M. Pharm. Chem. 2016 , 8 , 23 – 29
• [14] ICH, Q2 (R1), Validation of analytical procedures. In: Proceeding of the International Conference on Harmonization, Geneva, 2005.

Uwagi

PL

Opracowanie rekordu w ramach umowy 509/P-DUN/2018 ze środków MNiSW przeznaczonych na działalność upowszechniającą naukę (2018).