Role of the hydrophobic core in cytoskeleton protein: cardiac myosin binding protein C

• Autorzy: Gołda M. , Banach M. , Wiśniowski Z. , Ziajka W. , Roterman I.

Identyfikatory

DOI

10.1515/bams-2017-0018

• Języki publikacji: EN

Abstrakty

EN

Cardiac myosin binding protein C is the object of analysis presented in this paper. The fuzzy oil drop model was applied to analyze the status of the hydrophobic core in two forms of this protein: WT and R502W mutant. The status of the mutant is revealed to be of lower stability than the WT form. The high order of the hydrophobic core is interpreted as the factor of stability of the tertiary structure. The muscle proteins, which undergo significant structural changes as the consequence of external stretching forces, are expected to return to initial structures after the release of an external force. The mutant R502W appears to represent lower stability; thus, the return to the initial structure may be of lower probability. The comparable analysis to other muscle domains (titin) and immunoglobulin domains suggests the very subtle relation to the biological activity of these proteins.

Słowa kluczowe

EN

cardiac myosin; hydrophobicity; hypertrophic cardiomyopathy; immunoglobulin; muscle proteins; titin

• Wydawca: Uniwersytet Jagielloński - Collegium Medicum ; De Gruyter
• Czasopismo: Bio-Algorithms and Med-Systems
• Rocznik: 2017
• Tom: Vol. 13, no. 3
• Strony: 161--165
• Opis fizyczny: Bibliogr. 17 poz., rys., wykr.

Twórcy

autor

Gołda M.

• Medical Practice Maria Gołda, Zyblikiewicza 11/3, 31-029 Krakow, Poland

autor

Banach M.

• Department of Bioinformatics and Telemedicine, Jagiellonian University Medical College, Lazarza 16, 30-531 Krakow, Poland

autor

Wiśniowski Z.

• Department of Bioinformatics and Telemedicine, Jagiellonian University Medical College, Lazarza 16, 30-531 Krakow, Poland

autor

Ziajka W.

• Department of Bioinformatics and Telemedicine, Jagiellonian University Medical College, Lazarza 16, 30-531 Krakow, Poland

autor

Roterman I.

• Department of Bioinformatics and Telemedicine, Jagiellonian University Medical College, Lazarza 16, 30-531 Krakow, Poland

Bibliografia

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