Pharmacokinetics of isocorynoxeine in rat plasma after intraperitoneal administration by UPLC–MS/MS

• Autorzy: Zhan Haichao , Wei Zhen , Ren Ke , Tong Shuhua , Wang Xianqin , Wu Qing

Identyfikatory

DOI

10.1556/1326.2019.00716

• Języki publikacji: EN

Abstrakty

EN

Isocorynoxeine is one of the main alkaloids in Chinese medicinal herbs, and has pharmacological activities such as antihypertensive, sedative, anticonvulsant, and neuronal protection. It is an effective component of Uncaria for the treatment of hypertension. In this study, we used a fast and sensitive ultra-performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) to detect isocorynoxeine in rat plasma and investigated its pharmacokinetics in rats. Six rats were given isocorynoxeine (15 mg/kg) by intraperitoneal (i.p.) administration. Blood (100 μL) was withdrawn from the caudal vein at 5 and 30 min and 1, 2, 4, 6, 8, 12, and 24 h after administration. Chromatographic separation was achieved using a UPLC BEH C18 column using a mobile phase of acetonitrile–0.1% formic acid with gradient elution. Electrospray ionization (ESI) tandem mass spectrometry in the multiple reaction monitoring (MRM) mode with positive ionization was applied. Intra-day and inter-day precisions (relative standard deviation, %RSD) of isocorynoxeine in rat plasma were lower than 12%. The method was successfully applied in the pharmacokinetics of isocorynoxeine in rats after intraperitoneal administration. The t1/2 of isocorynoxeine is 4.9 ± 2.1 h, which indicates quick elimination.

Słowa kluczowe

EN

isocorynoxeine; pharmacokinetics; rat

• Wydawca: University of Silesia in Katowice ; Akademiai Kiado
• Czasopismo: Acta Chromatographica
• Rocznik: 2020
• Tom: Vol. 32, no. 4
• Strony: 260--263
• Opis fizyczny: Bibliogr. 34 poz., rys.

Twórcy

autor

Zhan Haichao

• Jinhua Central Hospital, Jinhua 321000, China

autor

Wei Zhen

• The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325035, China

autor

Ren Ke

• Ningbo YinZhou No.2 Hospital, Ningbo 315192, China

autor

Tong Shuhua

• Jinhua Central Hospital, Jinhua 321000, China

autor

Wang Xianqin

• Wenzhou Medical University, Wenzhou 325035, China

autor

Wu Qing

• The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325035, China

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Uwagi

PL

Opracowanie rekordu ze środków MNiSW, umowa Nr 461252 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2020).