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Toluene
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Toluen ma wszechstronne zastosowanie jako surowiec w procesie produkcji gumy, żywic, detergentów, barwników, leków, trinitrotoluenu, kwasu benzoesowego i diizocyanianu toluenu. Toluen jest składnikiem wielu takich produktów rynkowych, jak: farby, szelak, inhibitory korozji, rozcieńczalniki oraz środki czyszczące i sanitarne zawierające rozpuszczalniki organiczne. Narażenie zawodowe na toluen może występować na etapie produkcji, wytwarzania, konfekcjonowania i przechowywania półproduktów i produktów zawierających toluen, jak również ich stosowania, np. w trakcie malowania farbami i lakierami czy oczyszczania powierzchni. Toluen może wchłaniać się do organizmu przez płuca, z przewodu pokarmowego i przez skórę. Retencja par toluenu w płucach u ludzi wynosi około 60 ÷ 80%. Szybkość wchłaniania toluenu przez skórę wynosi w przypadku kontaktu 0,69 mg/cm2/h. Główną drogą przemiany toluenu u ludzi jest utlenianie reszty metylowej do grupy karboksylowej z utworzeniem kwasu benzoesowego, który następnie ulega sprzęganiu z glutationem z utworzeniem kwasu hipurowego. Półokres wydalania kwasu hipurowego z moczem po narażeniu inhalacyjnym wynosi około 3,5 h. Efekty krytyczne działania toluenu obejmują działanie drażniące na oczy, wpływ na reprodukcję, działanie oto toksyczne i neurotoksyczne. Wartość NOAEL dla działania neurotoksycznego toluenu (wykonywanie testów psychometrycznych) ustalono na poziomie około 375 mg/m3. Spontaniczne poronienia występowały u kobiet narażonych zawodowo na toluen o stężeniach rzędu 170 ÷ 550 mg/m3 (średnio 300 mg/m3). Narażenie na toluen powoduje podrażnienie układu oddechowego, oczu i ból głowy. Stężenie 150 mg/m3 toluenu przyjęto za wartość NOAEL dla tego typu skutków działania, a stężenie 375 mg/m3 za wartość LOAEL. Przyjmując za skutek krytyczny działanie drażniące, zaproponowano wartość NDS toluenu równą 100 mg/m3. Pozostawiono również oznakowanie normatywu literami „Sk” (substancja wchłania się przez skórę) i literami „Ft” (substancja działa toksycznie na płód). Ze względu na działanie drażniące związku ustalono wartość NDSCh toluenu równą 200 mg/m3. Oznaczanie stężenia kwasu hipurowego w moczu zastąpiono oznaczaniem stężenia o-krezolu. Wartość DSB (dopuszczalne stężenie w materiale biologicznym) ustalono na poziomie 0,5 mg o-krezolu/g kreatyniny w próbkach moczu pobranych po zakończeniu zmiany roboczej.
Toluene is a clear, colorless liquid with a distinctive smell. The largest source of toluene release is during the production, transport and use of gasoline, which contains 5 ÷ 7% toluene by weight. Toluene is used in making paints, paint thinners, lacquers and adhesives. Absorption of toluene results mainly from inhalation of its vapor. In human studies retention of toluene in the lungs has been estimated by different authors to be 60 ÷ 80%. Significant amounts may also be absorbed through the skin if there is contact with the liquid form. The rate of absorption through the skin amounts to about 0.69 mg/cm2/h. Following absorption, toluene is rapidly distributed, with the highest levels observed in adipose tissue followed by bone marrow, adrenals, kidneys, liver, brain and blood. A mean toluene half-life of toluene in blood amount to 4.5 h and to 3.8 h in alveolar air. Approximately 20% of the absorbed toluene is excreted unchanged in the expired air. A minute amount is excreted in urine. The reminder is oxidized by transformation of the methyl radical into the carboxyl radical, which is mainly conjugated with glycine to produce hippuric acis. Less than 1% of the dose is hydroxylated to cresols. Hippuric acid is excreted in urine with a biological half-life of 3.5 h. Adverse effects on the nervous system and respiratory tract irritation are the critical effects from inhalation exposure to toluene. Experimental exposure of human volunteers to toluene at about 375 mg/m3 did not produce statistically significant differences in the results of tests measuring psychometric performance and subjective evaluations of well-being when compared to controls (NOAEL). Spontaneous abortions were observed as result of occupational exposure to toluene in concentrations of 170 ÷ 550 mg/m3. Irritation of the nose and throat was reported in printers exposed to 375 mg/m3 of toluene for 6.5 h and in volunteers exposed to the same concentration of toluene for 6 h (LOAEL). The proposed occupational exposure limits OEL-TWA of 100 mg/m3 and OEL-STEL of 200 mg/m3 are based on the LOAEL of 375 mg/m3 for irritative properties of toluene. As toluene is absorbed through the skin and is potentially fetotoxic the “Sk” and “Ft” symbols should denote this compound. A BEI value of 0.5 mg of o-cresol in urine samples collected at the end of the workshift has been proposed.
Słowa kluczowe
Czasopismo
Rocznik
Tom
Strony
131--158
Opis fizyczny
Bibliogr. 95 poz., tab.
Twórcy
autor
- Instytut Medycyny Pracy im. prof. dr. med. Jerzego Nofera 91-348 Łódź ul. św. Teresy od Dzieciątka Jezus 8
Bibliografia
- 1.Abbate C. i in. (1993) Neurotoxicity induced by exposure to toluene. An electrophysiologic study. Int.
- 2.Arch. Occup. Environ. Health 64, 389-392.
- 3.ACGIH (2001) Biological exposure indices. Introduction. Cincinnati, OH.
- 4.ACGIH (2003) Toluene [W:] Documentation of threshold limit values and biological exposure indices. Cincinnati, OH.
- 5.ACGIH (2004) Threshold limit values for chemical substances and physical agents and biological exposure indices. Cincinnati, OH.
- 6.ACGIH (2006) Threshold limit values for chemical substances and physical agents and biological exposure indices. Cincinnati, OH.
- 7.ACGIH (2007) Threshold limit values for chemical substances and physical agents and biological exposure indices. Cincinnati, OH.
- 8.Andersen I. i in. (1983) Human response to controlled levels of toluene in six-hour exposures. Scand. J. Work Environ. Health. 9, 405-418.
- 9.Angerer J., Schildbach M., Krämer (1998) S-p-Toluylomercapturic acid in urine of workers exposed to toluene: a new biomarker for toluene exposure. Arch. Toxicol. 66, 309-315.
- 10.Bass M. (1970) Sudden sniffing death. JAMA 212, 2075-2079.
- 11.Baelum J. i in. (1985) Response of solvent-exposed printers and unexposed controls to six-hiur toluene exposure. Scand. J. Work Environment Health 11, 271-280.
- 12.Baelum J. i in. (1987) Toluene metabolism during exposure to varying concentrations combined with exercise. Int. Arch. Occup. Environ. Health 59, 281-294.
- 13.Baelum J. i in. (1990) Human response to varying concentrations of toluene. Int. Arch. Occup. Environ Health 62, 65-71.
- 14.Boey K.W. i in. (1997) Effects of occupational exposure to toluene: a neuropsychological study on workers in Singapore. Ann. Acad. Med. Singapore 26, 184-187.
- 15.De-Ceaurriz J.C. i in. (1981) sensory irritation caused by varius industrial airborne chemicals. Toxicol. Lett. 9, 137-143.
- 16.Cherry N., Venables H., Waldron H.A. (1983a) British studies on the neuropsychological effects of solvent exposure. Scand. J. Occup. Environ. Health, 10 (suppl.1), 10-13.
- 17.Cherry N. i in. (1983b) The effects of toluene and alcohol on psychomotor performance. Ergonomics 26, 1081-1087.
- 18.Chikasue F., Okamoto I., Miyazaki T. (1985) A case of death after glue sniffing. Hiroshima J. Med. Sci. 34, 419-423.
- 19.Courtney K.D. i in. (1986) A perinatal study of toluene in CD-1 micew. Fundam. Appl. Toxicol. 6, 145-154.
- 20.Da Silva V. i in. (1990) Developmental toxicology of in utreo exposure to toluene on malnourished and well nourished rats. Toxicology 64, 155-168.
- 21.Dawydzik L. i in.(2001) Opracowanie w ujęciu tabelarycznym danych o narażeniu zawodowym w nadzorowanych przez inspekcję sanitarną zakładach pracy w 2000 r. Sprawozdanie z realizacji umowy nr IMP-6/01. Łódź, IMP.
- 22.DFG, Deutsche Forschungsgemeinschaft (1999) Biological exposure values for occupational toxicants and carcinogens. Critical data evaluation for BAT and EKA Values. Vol. 3. Weinheim, Verlagesellschaft mbH, 264.
- 23.DFG (2006) List of MAK and BAT values 2006. Report nr 42. Weinheim, Wiley –VCH.
- 24.Dossing M. i in. (1983) Urinary hippuric acid and orthocresol excretion in man during experimental exposure to toluene. Br. J. Ind. Med. 40, 470-473.
- 25.Echeverria D. i in. (1989) Acute neurobehavioural effects of toluene. Brit. J. Ind. Med. 46, 483-495.
- 26.Echeverria D. i in. (1991) Acute behavioural comparisons of toluene and ethanol in human subjects. Brit. J. Ind. Med. 48, 750-761.
- 27.Foo S.C., Jeyarantram J., Koh D. (1990) Chronic neurobehavioral effects of toluene. Br. J. Ind. Med. 47, 480-484.
- 28.Franchini I. i in. (1983) Early indicators of renal damage in workers exposed to organic solvents. Int. Arch. Occup. Environ. Health 52, 1-9.
- 29.Ghittori S. i in. (1987) The urinary concentration of solvents as a biological monitoring indicator of exposure. Proposal for the biological equivalent exposure limit to nine solvents. Am. Ind. Hyg. Assoc. J. 48, 786-790.
- 30.Gibson J.E., Hardisty J.F. (1983) Chronic toxicity and oncogenicity bioassay of inhaled toluene in Fisher-344 rats. Fund. Appl. Toxicol. 3, 315-319.
- 31.Hass U. i in. (1999) Developmental neurotoxicity after toluene inhalation exposure in rats. Neorotoxicol. Teratol. 21, 349-357.
- 32.Hougaard K.S. i in. (1999) Effect of prenatal exposure to toluene on postnatal development and behavior in rats. Neurotoxicol Teratol. 21, 241-250.
- 33.Hudak A., Ungvary G. (1978) Embryotoxic effects of benzene and its methyl derivatives: toluene, xylene. Toxicology 11, 55-63.
- 34.Huff J. (1990) Toxicology and carcinogenesis studies of toluene (Cas 108-88-3) in F344/N rats and B6C3F1 mice (inhalation studies). US Department of Health and Human Services. National Institute of Health.
- 35.Ikeda M. (1995) Exposure to complex mixtures. Implications for biological monitoring. Toxicol. Lett. 77, 85-91.
- 36.Iregren A. (1982) Effects on physiological test performance of workers exposed to single solvent (toluene) – a comparison with effects of exposure to mixture of organic solvents. Neurobehav. Toxicol. Teratol. 4, 695-701.
- 37.Iregren A. i in. (1986) Experimental exposure to toluene in combination with ethanol intake. Psychophysiological function. Scand. J. Work Environ. Health. 12, 128-136.
- 38.Jakubowski M., Kostrzewski P. (1989) Excretion of methylbenzoic acid in urine as a result of single and combined exposure to m-xylene. Pol. J. Occup. Med. 2, 238-247.
- 39.Jang J.Y., Droy P.O (1996) Simulation of the toluene in venous blood with a physiologically based pharmacokinetic model. Ist application to biological exposure index development. Appl. Occup. Environ. Hyg. 11, 1092-1095.
- 40.Johnson A.C., Canlon B. (1994) Toluene exposure affects the functional activity of the outer hair cells. Hear Res. 72, 189-196.
- 41.Jones H.E., Balster R.L. (1997) Neurobehavioral consequences of intermittent prenetal exposure to high concentrations of toluene. Neurotoxicol Teratol. 19, 305-313.
- 42.Jones H.E., Balster R.L. (1998) Inhalant abuse in pregnancy. Obstetrics and Gynencology Clinics of North America 25, 153-167.
- 43.Kawai T. i in. (1993) Comparative evaluation of blood and urine analysis as a tool for biological monitoring of n-hexane and toluene. Int. Arch. Occup. Environ. Health. 65, S123-S126.
- 44.Kostrzewski P., Piotrowski J.K. (1991) Toluene determination in capillary blood as a biological indicator of exposure to low levels of toluene. Polish J. Occup. Med. Env. Health. 4, 249-259.
- 45.Loquet G., Campo P., Lataye R. (1999) Comparison of toluene-induced and styrene-induced hearing losses. Neurotoxicol Teratol. 21, 689-697.
- 46.Luderer U. i in. (1999) Reproductive endocrine effects of acute exposure to toluene in men and women. Occup. Environ. Health. 56, 657-666.
- 47.Meulenbelt J., de Groot G., Savelkoult T. (1990) Two cases of acute toluene intoxication. Br. J. Ind. Med. 47, 417-420.
- 48.Morata T.C., Fiorini A.C., Fischer F.M. (1997) Toluene-induced hearing loss among rotogravure printing workers. Scand. J. Work. Environ. Health 23, 289-298.
- 49.Morck H.I., Winkel P., Gyntelberg F. (1985) Helbredsdeffecten af toluenudsaettelse. Kobenhaven, Arbejdsmiliofondet [summary].
- 50.Muller J., Greff G. (1984) Relation between the toxicity of molecules of industrial value and their physico-chemical properties: test of upper airway irritation applied to 4 chemical groups. Food Chem. Toxicol. 22, 661-664.
- 51.Murata K., Araki S., Yokoyama K. (1993) Cardiac autonomic dysfunction in rotagravure printers exposed to toluene in relation to peripheral nerve conduction. Ind. Health. 31, 79-90.
- 52.Muttray A. i in. (1995) Effect of subacute occupational exposure to toluene on color vision.
- Int. J. Occup. Med. Environ. Health. 8, 339-345.
- 53.Ng T.P. i in. (1990) Urinary levels of proteins and metabolites in workers exposed to toluene. Int. Arch. Occup. Environ. Health. 62, 43-46.
- 54.Ng T.P., Foo S.Ch., Yoong T. (1992a) Risk of spontaneous abortion in workers exposed to toluene. Brit. J. Ind. Med. 49, 804-808.
- 55.Ng T.P., Foo S.Ch., Yoong T. (1992b) Menstrual function in workers exposed to toluene. Brit. J. Ind. Med. 49, 799-803.
- 56.Nielsen H.K., Alarie Y. (1982) Sensory irritation, pulmonary irritation, and respiratory stimulation by airborne benzene and alkylbenzenes: prediction of safe industrial exposure levels and correlation with their thermodynamic properties. Toxicol. Apel. Pharmacol. 65, 459-477.
- 57.Nise G. i in. (1989) Elimination of toluene frtom venous blood and adipose tissue after occupational exposure. Brit. J. Ind. Med. 46, 407-411.
- 58.NTP (1990) U.S. National Toxicology Program Toxicology and carcinogenesis studies of toluene in F344/N rats and B6C3F1 Mice (inhalation studies). NTP TR 371.DHHS 9NIH Pub.No.90-2826. NTP, Research Triangle Park, NC.
- 59.O’Brien E.T., Yeomn W.O., Hobby J.A.E. (1971) Hepatorenal damage from toluene in “glue sniffer”. Brit. Med. J. 2, 29-30.
- 60.Ono A., Sekita K., Ogawa Y. (1996) Reproductive and developmental toxicity studies of toluene II. Effects of inhalation exposure on fertility in rats. J. Environ. Pathol. Toxicol. Oncol. 15, 9-20.
- 61.Orbaek P., Nise G. (1989) Neurasthenic complaints and psychometric function of toluene-exposed rotogravure printers. Am. J. Ind. Med. 16, 67-77.
- 62.Ostergaard G. (2000) The Nordic Expert Group for criteria documentationof health risks from chemicals. 125. Toluene. Arbete och Halsa. Stockholm, National Institute of Working Life, 1-45.
- 63.Pierce C.H. i in. (2002) Toluene metabolites as biological indicators of exposure. Tox. Letters 129, 65-76.
- 64.Piotrowski J.K. (1977) Exposure tests for organic compounds in industrial toxicology. Cincinnati, U.S. Department of Health, Education and Welfare, 137.
- 65.Plenge-Bonig A., Karmaus W. (1999) Exposure to toluene in the printing industry is associated with subfecundity in women but not in men. Occup. Environ. Med. 56, 443-448.
- 66.Pozzani U.C., Weil C.S., Carpenter C.P. (1959) The toxicological basis of threshold limit values: 5. The experimental inhalation of vapor mixtures by rats, with notes upon the relationship between single dose inhalation and single dose oral data. Am. Ind. Hyg. Assos. J. 20, 364-369.
- 67.Pryor G.T. i in. (1983) Transient cognitive deficits and high-frequency hearing loss in weanling rats exposed to toluene. Neurobehav. Toxicol. Teratol. 5, 53-57.
- 68.Pryor G.T. i in. (1984) Factors affecting toluene-induced ototoxicity in rats. Neurobehav. Toxicol. Teratol. 6, 223-238.
- 69.Pyykko K., Tahti H., Vapaatalo H. (1977) Toluene concentrations in various tissues of rats after inhalation and oral administration. Arch. Toxicol. 38, 169-176.
- 70.Rebert C.S. i in. (1983) Toluene-induced hearing loss in rats evidenced by the brainstem auditoryevoked response. Neurobehav. Toxicol. Teratol. 5, 59-62.
- 71.Riihimaki V., Pfaffli P. (1978) Percutaneous absorption of solvent vapors in man. Scand. J. Work. Envioron. Health 4, 73-85.
- 72.Riihimaki V. i in. (1982) Acute solvent interactions with special reference to xylene. Scand. J. Work. Environ. Health 8, 77-79.
- 73.Russ G. i in. (1981) Renal failure from glue sniffing. Med. J. Aust. 2,121-123.
- Sato A. i in. (1974) Pharmacokinetics of benzene and toluene. Int. Arch. Arbeitsmed 33, 169-182.
- 74.Screicher H.Z. i in. (1981) Syndrome of toluene sniffing in adults. An. Int. Med. 94, 758-762.
- 75.Smyth H.F. i in. (1969) Range-finding toxicity data. List VII. Am. Ind. Hyg. Assoc. J. 30, 470-476.
- 76.Svensson B.G., Nise G., Englander V. (1990) Deaths and tumors among rotagravure printers exposed to toluene. Brit. J. Ind. Med. 47, 372-379.
- 77.Svensson B.G. i in. (1992a) Neuroendocrine effects in printing workers exposed to toluene. Br. J. Ind. Med. 49, 402-408.
- 78.Svensson B.G. i in. (1992b) Hormone status in occupational toluene exposure. Am. J. Ind. Med. 22, 99-107.
- 79.Tardiff R. i in. (1991) Effect of simultaneous exposure to toluene and xylene on their respective biological exposure indices in humans. Int. Arch. Occup. Environ. Health. 63, 279-284.
- 80.Thiel R., Chahoud I. (1997) Postnatal dvelopment and behaviour of Wistar rats after prenatal toluene exposure. Arch. Toxicol. 71, 258-265.
- 81.Toluen (1994) Kryteria Zdrowotne Środowiska .T. 52. Łódź, IMP.
- 82.Toxicological profile for toluene (update) (2000) U.S. Department of Health & Human Services. Public Health Service, Agency for Toxic Substances and Diseases Registry.
- 83.Truchon G., Tardif R., Brodeur J. (1999) o-Cresol. A good indicator of exposure to low levels of toluene. Appl. Occup. Environ. Hyg. 14, 677-681.
- 84.Ungvary G.Y., Manya S., Tatrai E. (1980) Effect of toluene inhalation on the liver of rats. Dependenceon sex, dose and exposure time. J. Hyg. Epidemiol. Microbiol. Immunol. 24, 243-252.
- 85.Ungvary G.Y. (1984) The possible contribution of industrial chemicals (organic solvents) to the incidence of congenital defects caused by teratogenic drugs and consumer goods. An experimental study. [W:] Prevention of physical and mental congenital defects. Part A The scope of the problem. New York, A.R. Liss Inc.
- 86.Venkatamran G. (1981) Renal damage and glue sniffing. Brit. Med. J. 284, 1467.
- 87.Vrca A. i in. (1995) Visual evoked potentials in individuals exposed to long-term low concentrations of toluene. Arch. Toxicol. 69, 337-340.
- 88.Vrca A., Karacic V., Bozievic D.(1996) Brainstem auditory evoked potentials in individuals exposed to long term low concentrations of toluene. Am. J. Ind. Med. 30, 62-66.
- 89.Vrca A., Karacic V., Bozievic D. (1997) Cognitive evoked potentials VEP P300 in persons occupationally exposed to low concentrations of toluene. Arch. Hig. Rada Toxicol. 48, 277-285.
- 90.Waldron H.A., Cherry N., Johnston J.D. (1983) The effect of ethanol on blood toluene concentrations. Int. Arch. Occup. Environ. Health. 51, 365-369.
- 91.Wallen M., Naslund P.H., Byfalt-Nordqvist M. (1984) The effects of ethanol on the kinetics of toluene in man. Toxicol. Appl. Pharmacol. 76, 414-419.
- 92.Wallen M., Holm S., Norqvist M.B. (1985) Co-exposure to toluene and p-xylene in man; uptake and elimination. Brit. J. Ind. Med. 42, 111-116.
- 93.Winek C.L., Wecht C.H., Collom W.D. (1968) Toluene fatality from glue sniffing. Pa Med. 71, 81.
- 94.Winneke G., Kramer U., Kastka J. (1976) Zur Beeinflussung psychomotorischer Leistungen durch Alkohol and durch verschidene Lösunsmitteldämpfe. [W:] Adverse effects of environmental chemical and psychotropic drug. T. 2. Amsterdam, Elsevier Scientific Publishing Company.
- 95.Yin S. i in. (1987) Symptoms and signs of workers exposed to bezene, toluene or the combinations. Ind. Health 25, 113-130.
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