A Monte Carlo study on the radio-sensitization effect of gold nanoparticles in brachytherapy of prostate by 103Pd seeds

• Autorzy: Jangjoo Amir Ghasemi , Ghiasi Hosein , Mesbahi Asghar

Identyfikatory

DOI

10.2478/pjmpe-2019-0012

• Języki publikacji: EN

Abstrakty

EN

¹⁰³Pd seed is being used for prostate brachytherapy. Additionally, the dose enhancement effect of gold nanoparticles (GNP) has been reported in previous studies. The aim of this study was to characterize the dosimetric effect of gold nanoparticles in brachytherapy with a ¹⁰³Pd source. Two brachytherapy seeds including ¹⁰³Pd source was simulated using MCNPX Monte Carlo code. The seeds’ models were validated by comparing the MC with reported results. Then, GNPs (10 nm in diameter) with a concentration of 7mg Au/g were simulated uniformly inside the prostate of a humanoid computational phantom. Additionally, the dose enhancement factor (DEF) of nanoparticles was calculated for both modeled brachytherapy seeds. A good agreement was found between the MC calculated and the reported dosimetric parameters. For both seeds, an average DEF of 23% was obtained in tumor volume for prostate brachytherapy. The application of GNPs in conjunction with ¹⁰³Pd seed in brachytherapy can enhance the delivered dose to the tumor and consequently leads to better treatment outcome.

Słowa kluczowe

EN

103Pd; prostate cancer; brachytherapy; Monte Carlo; gold nanoparticles

• Wydawca: Polskie Towarzystwo Fizyki Medycznej ; De Gruyter
• Czasopismo: Polish Journal of Medical Physics and Engineering
• Rocznik: 2019
• Tom: Vol. 25, Iss. 2
• Strony: 87--92
• Opis fizyczny: Bibliogr. 40 poz., rys., tab.

Twórcy

autor

Jangjoo Amir Ghasemi

• Radiation Oncology Department, Imam Reza Hospital, Tabriz

autor

Ghiasi Hosein

• Medical Radiation Sciences Research Team, Tabriz University of Medical Sciences, Tabriz

autor

Mesbahi Asghar

• Medical Radiation Sciences Research Team, Tabriz University of Medical Sciences, Tabriz
• Medical Physics Department, Medical School, Tabriz University of Medical Sciences, Tabriz

Bibliografia

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Uwagi

Opracowanie rekordu ze środków MNiSW, umowa Nr 461252 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2020).