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Introduction: The perfusion of a part of the lung depends on its distance from the pulmonary trunk (differences in vascular resistance) and on the horizontal plane (differences in hydrostatic pressure). The aim of this study was to determine the geometric parameters characterising their positions and sizes in order to analyse the diffusion of the ventilation/perfusion ratio. Material and methods: A developed virtual respiratory system has been supplemented with an appropriate model of pulmonary circulation that uses a lung outline that is divided into parts based on an anatomical atlas and a CT image; it comprises a 3D geometric model of the lungs that was developed using the Inventor CAD software (Autodesk, Inc, San Francisco, USA). Each panel was divided into 2 horizontal and 8 vertical parts; the 16-part division was then modified. Results: When taking human lungs as a research object and simulating their accompanying physical, biological, or biochemical phenomena, one necessary task is to construct a spatial model of the lungs that takes into account, and maintains awareness of, the limitations of the source of data that is relied upon. The developed modified geometric model of lung division turned out to be useful and was successfully applied to a virtual patient, among others, as part of the VirRespir project. Conclusions: Finally, we can conclude that the virtual cardiorespiratory system thus elaborated may serve as a proper tool for the preliminary analysis of such complex interactions, considering the elaborated model of the lung’s divisions and its future improvements.
Słowa kluczowe
Rocznik
Tom
Strony
52--68
Opis fizyczny
Bibliogr. 33 poz., rys., tab.
Twórcy
autor
- Department of Modeling and Supporting of Internal Organs Functions, Nalecz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Warsaw, Poland
autor
- Warsaw University of Technology, Faculty of Electronics and Information Technology, Institute of Radioelectronics and Multimedia Technology, Warsaw, Poland
autor
- Department of Modeling and Supporting of Internal Organs Functions, Nalecz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Warsaw, Poland
Bibliografia
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- 15. Gólczewski T, Zieliński K, Pałko KJ, Darowski M. A model of pulmonary circulation for cardiopulmonary interaction analysis. The International Journal of Artificial Organs. 2010;33(7):450-450.
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- 21. Varner VD, Nelson CM. Computational models of airway branching morphogenesis. Seminars in Cell & Developmental Biology. 2017;67:170–176. https://doi.org/10.1016/j.semcdb.2016.06.003
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- 27. Buess A, Van Muylem A, Nonclercq A, Haut B. Modeling of the Transport and Exchange of a Gas Species in Lungs With an Asymmetric Branching Pattern. Application to Nitric Oxide. Frontiers in Physiology. 2020;11:570015. https://doi.org/10.3389/fphys.2020.570015
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- 29. Maghsoudi-Ganjeh M, Mariano CA, Sattari S, Arora H, Eskandari M. Developing a Lung Model in the Age of COVID-19: A Digital Image Correlation and Inverse Finite Element Analysis Framework. Frontiers in Bioengineering and Biotechnology. 2021;9:684778. https://doi.org/10.3389/fbioe.2021.684778
- 30. Liu G, Bian W, Zu G, et al. Development of a 3D Printed Lung Model Made of Synthetic Materials for Simulation. The Thoracic and Cardiovascular Surgeon. 2022;70(4):355-360. https://doi.org/10.1055/s-0041-1731783
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Typ dokumentu
Bibliografia
Identyfikator YADDA
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