Electrospun Thermoplastic Polyurethane Mats Containing Naproxen– Cyclodextrin Inclusion Complex

• Autorzy: Akduman C. , Özgüney I. , Kumbasar E. P. A.

Identyfikatory

DOI

10.2478/aut-2014-0024

• Języki publikacji: EN

Abstrakty

EN

Incorporation of cyclodextrins (CDs) into electrospun nanofibrous materials can be considered as potential candidates for functional medical textile applications. Naproxen (NAP) is a type of non-steroidal anti-inflammatory drug commonly administered for the treatment of pain, inflammation and fever. Drug-inclusion complex formation with CDs is an approach to improve the aqueous solubility via molecular encapsulation of the drug within the cavity of the more soluble CD molecule. In this study, NAP or different NAP-CD inclusion complexes loaded nanofibres were successfully produced through electrospinning and characterised. The inclusion complex loaded mats exhibited significantly faster release profiles than NAP-loaded thermoplastic polyurethane (TPU) mats. Overall, NAP-inclusion complex loaded TPU electrospun nanofibres could be used as drug delivery systems for acute pain treatments since they possess a highly porous structure that can release the drug immediately.

Słowa kluczowe

EN

naproxen; β-cyclodextrin; 2-hydroxy propyl-β-CD; inclusion complex; electrospinning; drug release

PL

naproksen; β-cyklodekstryna; 2-hydroksy-propylo-β-CD; kompleks inkluzyjny; elektroprzędzalnictwo; uwalnianie leku

• Wydawca: Lodz University of Technology, Faculty of Material Technologies and Textile Design
• Czasopismo: Autex Research Journal
• Rocznik: 2014
• Tom: Vol. 14, no. 4
• Strony: 239--246
• Opis fizyczny: Bibliogr. 27 poz.

Twórcy

autor

Akduman C.

• Pamukkale University, Denizli Vocational School of Technical Sciences, Department of Textile Technology, Denizli, Turkey

autor

Özgüney I.

• Ege University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Izmir, Turkey

autor

Kumbasar E. P. A.

• Ege University, Faculty of Engineering, Department of Textile Engineering, Izmir, Turkey

Bibliografia

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