Increased quality of life indices among sepsis survivors rehabilitated in the RehaSep trial

• Autorzy: Wójcik Barbara , Superata Jerzy , Nguyen Bryant , Piwowar Monika Weronika , Szyguła Zbigniew

Identyfikatory

DOI

10.5604/01.3001.0054.9272

• Języki publikacji: EN

Abstrakty

EN

Objective: In this study, the gap was addressed in effective rehabilitation methodologies for preventing sepsis sequelae utilising a novel, two-way, diagnostically-monitored personalised rehabilitation model implemented to enhance quality of life (QoL) among sepsis survivors. Methods: Of 66 sepsis survivors post-hospital discharge, and those who met the inclusion criteria, 30 were eventually allocated into three groups: a control group (Group C, n = 10, no rehabilitation) and two intervention groups undergoing three- -month, diagnostically-monitored rehabilitation programmes. Group E (n = 10) received personalised aerobic and functional training, while Group H (n = 10) underwent intermittent hyperbaric oxygen therapy as a novel rehabilitative treatment alternative. QoL was evaluated at hospital discharge and again after 3 months using the newly developed Life After Sepsis Survey. Results: After three months, statistically significant (p < 0.05) improvement was observed in QoL among sepsis survivors from both intervention groups concerning the significant parts of the assessed physiological, physical and psychological functions. Conclusions: The personalised, patient-centric and supportive approach significantly improved QoL among sepsis survivors, highlighting the potential effectiveness of this rehabilitation model. The Life After Sepsis proved to be a practical assessment tool and currently stands as a uniquely suitable measure for evaluating sepsis rehabilitation outcomes.

Słowa kluczowe

EN

hyperbaric oxygen therapy; rehabilitation; sepsis; sepsis survivors; quality of life

• Wydawca: Uniwersytet Jagielloński - Collegium Medicum ; Index Copernicus Sp. z o.o.
• Czasopismo: Bio-Algorithms and Med-Systems
• Rocznik: 2024
• Tom: Vol. 20, no. 1
• Strony: 146--158
• Opis fizyczny: Bibliogr. 47 poz., tab., wykr.

Twórcy

autor

Wójcik Barbara

• Department of Clinical Rehabilitation, University of Physical Education in Kraków; Al. Jana Pawla II 78, 31-571 Kraków, Poland

• https://orcid.org/0000-0003-0761-581X

autor

Superata Jerzy

• Department of Clinical Rehabilitation, University of Physical Education in Kraków, Kraków, Poland

autor

Nguyen Bryant

• Division of Pulmonary, Critical Care, Hyperbaric and Sleep Medicine, Department of Medicine and Emergency Medicine, Loma Linda University, Loma Linda, CA, USA

• https://orcid.org/0000-0002-1297-6639

autor

Piwowar Monika Weronika

• Department of Bioinformatics and Telemedicine, Faculty of Medicine, Jagiellonian University Medical College, Kraków, Poland

• https://orcid.org/0000-0003-4645-8730

autor

Szyguła Zbigniew

• Department of Nutrition and Sport Medicine, University of Physical Education in Kraków, Kraków, Poland

• https://orcid.org/0000-0002-6685-6579

Bibliografia

• 1. Fleischmann-Struzek C, Mellhammar L, Rose N, Cassini A, Rudd KE, Schlattmann P, et al. Incidence and mortality of hospital- and ICU-treated sepsis: results from an updated and expanded systematic review and meta-analysis. Intensive Care Med. 2020;46(8):1552-62. doi: https://doi.org/10.1007/s00134-020-06151-x.
• 2. Rudd KE, Johnson SC, Agesa KM, Shackelford KA, Tsoi D, Kievlan DR, et al. Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the Global Burden of Disease Study. Lancet. 2020;395(10219):200-11. doi: https://doi.org/10.1016/S0140-6736(19)32989-7.
• 3. Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016;315:801-10. doi: https://doi.org/10.1001/jama.2016.0287.
• 4. Prescott HC, Osterholzer JJ, Langa KM, Angus DC, Iwashyna TJ. Late mortality after sepsis: propensity matched cohort study. BMJ. 2016;353:i2375. doi: https://doi.org/10.1136/bmj.i2375.
• 5. Shankar-Hari M, Saha R, Wilson J, Prescott HC, Harrison D, Rowan K, et al. Rate and risk factors for rehospitalisation in sepsis survivors: systematic review and meta-analysis. Intensive Care Med. 2020;46(4):619-36. doi: https://doi.org/10.1007/s00134-019-05908-3.
• 6. Evans L, Rhodes A, Alhazzani W, Antonelli M, Coopersmith CM, French C, et al. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock. Intensive Care Med. 2021;47(11):1181-1247. doi: https://doi.org/10.1007/s00134-021-06506-y.
• 7. Prescott HC, Angus DC. Enhancing recovery from sepsis: a review. JAMA. 2018;319(1):62-75. doi: https://doi.org/10.1001/jama.2017.17687.
• 8. Carr AJ, Higginson IJ. Are quality of life measures patient centred? BMJ. 2001;322(7298):1357-60. doi: https://doi.org/10.1136/ bmj.322.7298.1357.
• 9. Reinhart K, Daniels R, Kissoon N. Recognizing Sepsis as a Global Health Priority - A WHO Resolution. NEJM. 2017;377(5):414-17. https://doi.org/10.1056/NEJMp1707170.
• 10. van der Slikke EC, Beumeler LFE, Holmqvist M, Linder A, Mankowski RT, Bouma HR. Understanding Post-Sepsis Syndrome: How Can Clinicians Help? Infect Drug Resist. 2023;16:6493-6511. doi: https://doi.org/10.2147/IDR.S390947.
• 11. Scruth E. Life After Sepsis: The Journey Continues. Criti Care Med 2023;51(10):1439-41. doi: https://doi.org/10.1097/CCM.0000000000005970.
• 12. Iwashyna TJ. Survivorship will be the defining challenge of critical care in the 21st century. Ann Intern Med. 2010;153:204-5. doi: https://doi.org/10.7326/0003-4819-153-3-201008030-00013.
• 13. Marx G, Zimmer A, Rothaug J, Mescha S, Reinhart K, Meissner W. Chronic pain after surviving sepsis. Crit Care. 2016;10(Suppl 1):P421. doi: https://doi.org/10.1186/cc4768.
• 14. Myhren H, Ekeberg O, Tøien K, Karlsson S, Stokland O. Posttraumatic stress, anxiety and depression symptoms in patients during the first year post intensive care unit discharge. Crit Care. 2010;14(1):R14. doi: https://doi.org/10.1186/cc8870.
• 15. Iwashyna TJ, Ely EW, Smith DM, Langa KM. Long-term cognitive impairment and functional disability among survivors of severe sepsis. JAMA. 2010;304:1787-94. doi: https://doi.org/10.1001/jama.2010.1553.
• 16. Hopkins RO, Key CW, Suchyta MR, Weaver LK, Orme JF. Risk factors for depression and anxiety in survivors of acute respiratory distress syndrome. Gen Hosp Psychiatry. 2010;32:147-55. doi: https://doi.org/10.1016/j.genhosppsych.2009.11.003.
• 17. Jackson JC, Hart RP, Gordon SM, Shintani A, Truman B, May L, et al. Sixmonth neuropsychological outcome of medical intensive care unit patients. Crit Care Med. 2003;31:1226-34. doi: https://doi.org/10.1097/01.CCM.0000059996.30263.94.
• 18. Weinert C, Meller W. Epidemiology of depression and antidepressant therapy after acute respiratory failure. Psychosom. 2006;47:399-407. doi: https://doi.org/10.1176/appi.psy.47.5.399.
• 19. Mira JC, Brakenridge SC, Moldawer LL, Moore FA. Persistent inflammation, immunosuppression and catabolism syndrome. Crit Care Clin. 2017;33(2):245-58. doi: https://doi.org/10.1016/j. ccc.2016.12.001.
• 20. DeMerle KM, Angus DC, Baillie JK, Brant E, Calfee CS, Carcillo J, et al. Sepsis Subclasses: A Framework for Development and Interpretation. Crit Care Med. 2021;49(5):748-59. doi: https://doi.org/10.1097/CCM.0000000000004842.
• 21. Varon J, Baron RM. Sepsis endotypes: The early bird still gets the worm. EBioMedicine. 2022;76:103832. doi: https://doi.org/10.1016/j.ebiom.2022.103832.
• 22. Wójcik B, Superata J, Nguyen HB, Szyguła Z. Exploration of Different Rehabilitation Routes for Sepsis Survivors with Monitoring of Health Status and Quality of Life: RehaSep Trial Protocol. Adv Ther. 2019;36(10):2968-78. doi: https://doi.org/10.1007/s12325-019-01047-9.
• 23. Huang CY, Daniels R, Lembo A, Hartog C, O’Brien J, Heymann T, et al. Life after sepsis: an international survey of survivors to understand the post-sepsis syndrome IJQHC. 2018;31(3):191-8. doi: https://doi. org/10.1093/intqhc/mzy137.
• 24. unmc.edu [Internet]. Group PHOPC. PROMIS-29. 2009 [cited 2024 May 26]. Available from: https://www.unmc.edu/centric/_documents/ PROMIS-29.pdf.
• 25. Szczesny W. On the performance of a discriminant function. J Classif. 1991;8:201-15. doi: https://doi.org/10.1007/BF02616239.
• 26. Piwowar M, Kocemba-Pilarczyk KA, Piwowar P. Regularization and grouping-omics data by GCA method: A transcriptomic case. PLoS One. 2018;13(11):e0206608. doi: https://doi.org/10.1371/journal. pone.0206608.
• 27. Schmidt, K., Worrack, S., Von Korff, M, Davydow D, Brunkhorst F, Ehlert U, et al. Effect of a primary care management intervention on mental healthrelated quality of life among survivors of sepsis: A randomized clinical trial. JAMA. 2016;315(24):2703-11. doi: https://doi.org/10.1001/jama.2016.7207.
• 28. Turnbull AE, Rabiee A, Davis WE, Nasser MF, Venna VR, Lolitha R, et al. Outcome measurement in ICU survivorship research from 1970 to 2013: A scoping review of 425 publications. Crit Care Med. 2016;44(7):1267-77. doi: https://doi.org/10.1097/CCM.0000000000001651.
• 29. Ware JE, Sherbourne CD. The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care. 1992;30(6):473-83.
• 30. EuroQol Group. EuroQol – A new facility for the measurement of health-related quality of life. Health Policy. 1990;16(3):199-208.
• 31. Ramsay P. Health-related quality of life: Implications for critical care interventional studies and why we need to collaborate with patients. Curr Opin Crit Care. 2011;17(5):510-4. doi: https://doi.org/10.1097/MCC.0b013e32834a4bd4.
• 32. König C, Matt B, Kortgen A, Turnbull AE, Hartog CS. What matters most to sepsis survivors: a qualitative analysis to identify specific health-related quality of life domains. Qual Life Res. 2019;28(3):637-47. doi: https://doi.org/10.1007/s11136-018-2028-8.
• 33. Lim WC, Black N, Lamping D, Rowan K, Mays N. Conceptualizing and measuring health-related quality of life in critical care. J Crit Care. 2016;31(1):183-93. doi: https://doi.org/10.1016/j.jcrc.2015.10.020.
• 34. Singer JP, Chen J, Katz PP, Blanc PD, Kagawa-Singer M, Stewart AL. Defining novel health-related quality of life domains in lung transplantation: A qualitative analysis. Qual Life Res. 2015;24(6):1521-33. doi: https://doi.org/10.1007/s11136-014-0875-5.
• 35. Connolly B, Salisbury L, O’Neill B, Geneen LJ, Douiri A, Grocott MP, et al. Exercise rehabilitation following intensive care unit discharge for recovery from critical illness. CDSR. 2015;6:1-4. doi: https://doi.org/10.1002/14651858.CD008632.
• 36. Rahmel T, Schmitz S, Nowak H, Schepanek K, Bergmann L, Halberstadt P, et al. Long-term mortality and outcome in hospital survivors of septic shock, sepsis, and severe infections: The importance of aftercare. PLoS One. 2020;15(2):e0228952. doi: https://doi.org/10.1371/journal. pone.0228952.
• 37. Schmidt KF, Schwarzkopf D, Baldwin LM, Brunkhorst FM, Freytag A, Heintze C, et al. Long-Term Courses of Sepsis Survivors: Effects of a Primary Care Management Intervention. Am J Med. 2020;133(3);381-5. e5. doi: https://doi.org/10.1016/j.amjmed.2019.08.033.
• 38. Apitzsch S, Larsson L, Larsson AK, Linder A. The physical and mental impact of surviving sepsis - a qualitative study of experiences and perceptions among a Swedish sample. Arch Pub Health. 2021;79(1):66. doi: https://doi.org/10.1186/s13690-021-00585-5.
• 39. Gallop KH, Kerr CE, Nixon A, Verdian L, Barney JB, Beale RJ. A qualitative investigation of patients’ and caregivers’ experiences of severe sepsis. Crit Care Med. 2015;43(2):296-307. doi: https://doi.org/10.1097/CCM.0000000000000613.
• 40. Jensen US, Knudsen JD, Wehberg S, Gregson DB, Laupland KB. Risk factors for recurrence and death after bacteraemia: a population-based study. CMI. 2011;17:1148-54. doi: https://doi.org/10.1111/j.1469-0691.2011.03587.x.
• 41. Prescott HC. Toward a Nuanced Understanding of the Role of Infection in Readmissions After Sepsis. Crit Care Med. 2016;44:634-5. doi: https://doi.org/10.1097/CCM.0000000000001508.
• 42. Sun A, Netzer G, Small DS. Association Between Index Hospitalization and Hospital Readmission in Sepsis Survivors. Crit Care Med. 2016;44:478-87. doi: https://doi.org/10.1097/CCM.0000000000001464.
• 43. Suzuki K, Inoue S, Kametani Y, Komori Y, Chiba S, Sato T, et al. Reduced Immunocompetent B Cells and Increased Secondary Infection in Elderly Patients With Severe Sepsis. Shock. 2016;46(3):270-8. https://doi.org/10.1097/SHK.0000000000000619.
• 44. Wang T, Derhovanessian A, De Cruz S, Belperio JA, Deng JC, Hoo GS. Subsequent infections in survivors of sepsis: epidemiology and outcomes. J Intensive Care Med. 2014;29,87-95. doi: https://doi.org/10.1177/0885066612467162.
• 45. Gritte RB, Souza-Siqueira T, Curi R, Machado MC, Soriano FG. Why Septic Patients Remain Sick After Hospital Discharge? Front Immunol. 2021;11:605666. doi: https://doi.org/10.3389/fimmu.2020.605666.
• 46. Umberger RA, Thomas SP. Survivor but not fully recovered: the lived experience after 1 year of surviving sepsis. Dimens Crit Care Nurs. 2019;38(6):317-27. doi: https://doi.org/10.1097/ DCC.0000000000000381.
• 47. Born S, Matthäus-Krämer C, Bichmann A, Boltz HS, Esch M, Heydt L, et al. Sepsis survivors and caregivers perspectives on post-acute rehabilitation and aftercare in the first year after sepsis in Germany. Front Med (Lausanne). 2023;10:1137027. doi: https://doi.org/10.3389/fmed.2023.1137027.