The comparative study of influence of lactic and glycolic acids copolymers type on properties of daunorubicin loaded nanoparticles and drug release

• Autorzy: Nikolskaya E. , Sokol M. , Faustova M. , Zhunina O. , Mollaev M. , Yabbarov N. , Tereshchenko O. , Popov R. , Severin E.

Identyfikatory

DOI

10.5277/ABB-01028-02

• Języki publikacji: EN

Abstrakty

EN

The aim of this study was to compare the physico-chemical and biological properties of polymeric nanoparticles obtained from poly(DL-lactide-co-glycolide) (PLGA) with different ratios of monomers loaded with daunorubicin (DNR). Methods: DNR-loaded nanoparticles (NPs) were prepared with use of modified simultaneous double-emulsion solvent evaporation/diffusion technique. NPs were characterized using dynamic light scattering, atomic force microscopy, transmission electron microscopy, scanning electron microscopy, and differential scanning calorimetry and Fourier transform infrared spectroscopy. Results: NPs with DNR were differing in size and zeta potential, depending on the type of polymer. The data obtained show that total content of DNR correlates with the values of the binding constant of DNR with polymers. The release of DNR from NPs proceeds predominantly for polymers with lower binding constants. The in vitro study of NPs on the MCF-7 cells showed similar activity of particles and substances while for the anthracycline-resistant MCF-7Adr cells the cytotoxicity of the nanoparticles was 3 to 7 times higher depending on the type of copolymer. Conclusions: PLGA DNR-loaded nanoparticles can be used to overcome multidrug resistance (MDR) as well as for reducing the frequency of DNR reception due to the prolonged effect, which allows maintaining the concentration of the drug at the required level. The usefulness of binding constant calculations for obtaining nanoparticles with the maximum drug loading was proven. The rate of drug administration and the frequency of administration can be calculated based on the DNR release profiles and release parameters that depend on polymer type.

Słowa kluczowe

EN

nanoparticles; daunorubicin; PLGA; controlled release; MCF7/MCF7 Adr; dissociation constant

PL

nanocząsteczki; daunorubicyna; PLGA; uwalnianie kontrolowane; stała dysocjacji

• Wydawca: Oficyna Wydawnicza Politechniki Wrocławskiej
• Czasopismo: Acta of Bioengineering and Biomechanics
• Rocznik: 2018
• Tom: Vol. 20, no. 1
• Strony: 65--77
• Opis fizyczny: Bibliogr. 28 poz., rys., tab., wykr.

Twórcy

autor

Nikolskaya E.

• Moscow Technological University, Moscow, Russian Federation
• Russian Research Center for Molecular Diagnostics and Therapy, Moscow, Russian Federation

autor

Sokol M.

• Moscow Technological University, Moscow, Russian Federation
• Russian Research Center for Molecular Diagnostics and Therapy, Moscow, Russian Federation

autor

Faustova M.

• Moscow Technological University, Moscow, Russian Federation
• Russian Research Center for Molecular Diagnostics and Therapy, Moscow, Russian Federation

autor

Zhunina O.

• Russian Research Center for Molecular Diagnostics and Therapy, Moscow, Russian Federation

autor

Mollaev M.

• Moscow Technological University, Moscow, Russian Federation
• Russian Research Center for Molecular Diagnostics and Therapy, Moscow, Russian Federation

autor

Yabbarov N.

• Russian Research Center for Molecular Diagnostics and Therapy, Moscow, Russian Federation

autor

Tereshchenko O.

• Russian Research Center for Molecular Diagnostics and Therapy, Moscow, Russian Federation

autor

Popov R.

• Moscow Technological University, Moscow, Russian Federation
• Russian Research Center for Molecular Diagnostics and Therapy, Moscow, Russian Federation

autor

Severin E.

• Russian Research Center for Molecular Diagnostics and Therapy, Moscow, Russian Federation

Bibliografia

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Uwagi

Opracowanie rekordu w ramach umowy 509/P-DUN/2018 ze środków MNiSW przeznaczonych na działalność upowszechniającą naukę (2018).