Diffusion and migration of nano particles and filaments suspended in oscillating flow

Pawłowska, S.

Artykuł - szczegóły

Tytuł artykułu

Diffusion and migration of nano particles and filaments suspended in oscillating flow

Autorzy

Pawłowska S.

Treść / Zawartość

Pełne teksty:

IPPT_Reports_2018_2_Sylwia_Pawlowska_online_24_June_2018.pdf

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Identyfikatory

Warianty tytułu

Dyfuzja i migracja nano cząstek i filamentów zawieszonych w przepływie oscylacyjnym

Języki publikacji

Abstrakty

The subject of this work is an experimental analysis of the dynamics of nanoobjects suspended in a liquid. The research will make it possible to appreciate the role played by hydrodynamic and ionic interactions on the transport properties of Brownian solid spherical objects, as well as strongly deformable nanofilaments and macromolecules. In the first stage of the work, an analysis of the Brownian fluctuations of spherical nanoparticles suspended in electrolytes was conducted. This report presents the results of the research carried out on the influence of the medium ionic strength and the wall on the size of the apparent (hydrodynamic) diameter of these spherical nanoobjects. The second stage of the research concerns the mobility of deformable nanoobjects with a structure similar to long macromolecules. These are nanofilaments made of a hydrogel material. The original coaxial electrospinning technique was developed to produce them. This technique allows for the fabrication of core-shell fibres, with a highly elastic hydrogel filamentous core. The mechanical properties of nanofilaments are evaluated by analysing their Brownian characteristics. The aim of this analysis is to determine the value of the persistent length of the object analysed, which is correlated with its bending Young's module. After assessing their full morphological characteristics and mechanical properties, the behaviour of hydrogel nanofilaments in the flow was analysed. An experimental system was used to analyse the dynamics of filament deformation and the migration of nanofilaments in the oscillating flow, simulating intercellular and inter-tissue flows in living organisms. The basic goal of the analysis of the dynamics of nanofilaments is the possibility to use them as models of elongated biological particles, such as proteins and DNA. The analysis of their movement and deformation in the flow will support the verification of existing theoretical models, and will expand our understanding of the physical phenomena which are responsible for the folding dynamics of long biomolecules. Another very important aim of this work is to offer the possibility of using such highly deformable, biocompatible objects in biomedical applications.

Przedmiotem pracy jest eksperymentalna analiza dynamiki nanoobiektów zawieszonych w cieczy. Badania pozwolą na ocenę roli oddziaływań hydrodynamicznych, chemicznych i fluktuacji brownowskich na dynamikę i parametry transportu w mikro i nanoskali dla obiektów sferycznych, silnie deformowalnych filamentów i makromolekuł. W pierwszym etapie pracy przeprowadzono analizę ruchów brownowskich sferycznych nanocząstek zawieszonych w elektrolitach. W pracy przedstawiono wyniki przeprowadzonych badań dotyczących wpływu siły jonowej medium oraz bliskości ścianki na wielkość średnicy hydrodynamicznej tychże sferycznych nanoobiektów (efektywnego oporu lepkiego). Drugi etap badań dotyczył mobilności deformowalnych nanoobiektów o strukturze analogicznej do długich makromolekuł. Są to wytworzone z materiału hydrożelowego nanofilamenty. Opracowano oryginalną metodę ich wytwarzania, wykorzystującą technikę elektroprzędzenia współosiowego. Nowością w prowadzonych badaniach jest zamknięcie hydrożelowego materiału w postaci filamentów, charakteryzujących się dodatkowo wysoką elastycznością. Po pełnej charakterystyce morfologicznej oraz właściwości mechanicznych, hydrożelowe nanofilamenty poddane zostały analizie ich zachowania w przepływie. Stworzony układ eksperymentalny, posłużył do analizy dynamiki deformacji oraz zjawiska migracji nanofilamentów w przepływie oscylacyjnym, symulującym przepływy międzykomórkowe i międzytkankowe w żywych organizmach. W pracy zbadane zostało zjawisko migracji w poprzek kanału. To zagadnienie jest istotne dla opisu transportu deformowalnych makromolekuł w kapilarach. Przeprowadzone badania dynamiki nanofilamentów stwarzają możliwość ich wykorzystania jako modeli wydłużonych cząstek biologicznych (białka, DNA), weryfikacji istniejących już modeli teoretycznych, oraz zrozumienia zjawisk fizycznych odpowiedzialnych za fałdowanie i dynamikę zginania biomolekuł. Kolejnym bardzo ważnym celem pracy jest możliwość wykorzystania takich silnie deformowalnych, biokompatybilnych obiektów w zastosowaniach biomedycznych.

Słowa kluczowe

nanotechnology dynamics nanofilament

nanotechnologia dynamika nanofilament

Wydawca

Instytut Podstawowych Problemów Techniki PAN

Czasopismo

IPPT Reports on Fundamental Technological Research

Rocznik

2018

Tom

nr 2

Strony

1--106

Opis fizyczny

Bibliogr. 115 poz., rys., tab.

Twórcy

autor

Pawłowska S.

Institute of Fundamental Technological Research, Polish Academy of Sciences

Bibliografia

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Uwagi

Opracowanie rekordu w ramach umowy 509/P-DUN/2018 ze środków MNiSW przeznaczonych na działalność upowszechniającą naukę (2019).

Typ dokumentu

Bibliografia

Identyfikator YADDA

bwmeta1.element.baztech-6b759a9f-3cd7-4354-930d-c4c846ecff5f