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Abstrakty
A HPLC-DAD method for simultaneous analysis of five flavonoids (rutin, quercitrin, quercetin, kaempferol, and isorhamnetin) in diabetic rat plasma has been developed and validated. Separation of the five flavonoids was accomplished on a C 18 column (250 mm × 4.6 mm i.d., 5-µm particle) and detection was performed at 350 nm. The best resolution was achieved with a methanol-0.1% formic acid gradient at a flow rate of 1.0 mL min −1 . The correlation coefficients for all the calibration plots ( r > 0.999) showed linearity was good over the range tested. The relative standard deviation of the method was less than 7% and 10% for intra- and inter-day assays, and average recovery was between 77.2 and 99.2%. Sensitivity was high and detection limits were between 0.006 and 0.02 µg mL −1 . The method has been successfully used to determine drug concentrations in diabetic rat plasma samples and the pharmacokinetics of the drugs.
Czasopismo
Rocznik
Tom
Strony
483--497
Opis fizyczny
Bibliogr. 29 poz., rys., tab.
Twórcy
autor
- Ministry of Education Key Laboratory of Drug Quality Control and Pharmacovigilance Nanjing Jiangsu 210009 China
- China Pharmaceutical University Center for Instrumental Analysis Nanjing Jiangsu 210009 China
autor
- Xuzhou Medical College Department of Pharmaceutical Analysis Xuzhou Jiangsu 221004 China
autor
- Ministry of Education Key Laboratory of Drug Quality Control and Pharmacovigilance Nanjing Jiangsu 210009 China
- China Pharmaceutical University Center for Instrumental Analysis Nanjing Jiangsu 210009 China
autor
- Xuzhou Medical College Department of Pharmaceutical Analysis Xuzhou Jiangsu 221004 China
autor
- Xuzhou Medical College Department of Pharmaceutical Analysis Xuzhou Jiangsu 221004 China
autor
- Xuzhou Medical College Department of Pharmaceutical Analysis Xuzhou Jiangsu 221004 China
autor
- Xuzhou Medical College Department of Pharmaceutical Analysis Xuzhou Jiangsu 221004 China
Bibliografia
- [1] World Health Organization/International Diabetes Federation: The Economics of Diabetes and Diabetes Care — A Report of the Diabetes Health Economics Study Group. WHO, Geneva, 1999
- [2] Y.C. Kim, E.Y. Oh, S.H. Kim, and M.G. Lee, Biopharm. Drug Dispos., 26 , 371 (2005)
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- [8] K. Welt, J. Weiss, R. Martin, D. Dettmer, T. Hermsdorf, K. Asayama, S. Meister, and G. Fitzl, Exp. Toxicol. Pathol., 55 , 331 (2004)
- [9] K. Welt, J. Weiss, R. Martin, T. Hermsdorf, S. Drews, and G. Fitzl, Phytomedicine, 14 , 196 (2007)
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- [21] Q.J. Yang, G.Z. Wu, W.J. Xue, Y.N. Tang, and X.Q. Wu, Herald Med., 21 , 687 (2002)
- [22] R.P. Webster, M.D. Gawde, and R.K. Bhattacharya, Cancer Lett., 109 , 185 (1996)
- [23] A.P. Rogerio, A. Kanashiro, C. Fontanari, E.V.G. da Silva, Y.M. Lucisano-Valim, E.G. Soares, and L.H. Faccioli, Inflamm. Res., 56 , 402 (2007)
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- [29] W.Q. Sun and J.F. Sheng, Handbook of Natural Active Constituents, Chinese Medicinal Science and Technology Press, Beijing, 1998, p. 2240
Typ dokumentu
Bibliografia
Identyfikator YADDA
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