Green synthesis of pyrimidine derivative

• Autorzy: Sonawane R. P.
• Języki publikacji: EN

Abstrakty

EN

The majority of the drugs on the market today are entirely chemically synthesized in the laboratory. Several scientists had synthesized dihydropyrimidine (DHPMs) derivatives showing a wide spectrum of biological actions as antibacterials, antivirals as well as antitumor agents. This activity is principally due to presence of steriogenic carbon C4 in their structure. The current investigation is study and synthesis of dihydropyrimidinones efficiently and in high yields under mild, solvent free and eco-friendly conditions by using “Grindstone Chemistry Technique” catalyzed by CuCl2•2H2O and Conc. HCl. The obtained products have been identified by comparison with spectral data & their melting points. The synthesis of DHPMs derivative involves a multicomponent reaction (aldehyde derivative, urea /thiourea and 1,3-dicarbonyl compounds) in presence of HCl / NH4Cl as a catalyst. 3,4-dihydropyrimidin-2-(1H)-ones was synthesized and characterized using IR. The melting points was obtained 203 °C.

Słowa kluczowe

EN

dihydropyrimidine derivatives; Biginelli reaction; Grindstone chemistry

• Wydawca: Przedsiębiorstwo Wydawnictw Naukowych "DARWIN"
• Czasopismo: International Letters of Chemistry, Physics and Astronomy
• Rocznik: 2014
• Tom: Vol. 2
• Strony: 64--68
• Opis fizyczny: Bibliogr. 11 poz., tab., wz.

Twórcy

autor

Sonawane R. P.

• The Institute of Science, Mumbai 400032, India

Bibliografia

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• [10] Hue-Ming Hua, Jiangnan Peng, Tetrahedran 63(45) (2007) 11179-11188.
• [11] R. P. Sonawane, International Letters of Chemistry, Physics and Astronomy 5 (2013) 7-11.