Strength, Water Absorption, Thermal and Antimicrobial Properties of a Biopolymer Composite Wound Dressing

• Autorzy: Odili Cletus Chiosa , Sekunowo Olatunde Israel , Ilomuanya Margaret Okonawan , Gbenebor Oluwashina Philips , Adeosun Samson Oluropo

Identyfikatory

DOI

10.7494/jcme.2022.6.1.22

• Języki publikacji: EN

Abstrakty

EN

Conventional wound material allows bacterial invasions, trauma and discomfort associated with the changing of the dressing material, and the accumulation of body fluid for wounds with high exudate. However, there is a shift from conventional wound dressing materials to polymeric nanofibers due to their high surface area to volume ratio, high porosity, good pore size distribution, which allows for cell adhesion and proliferation. There is an urgent need to synthesis a biodegradable composite that is resistant to bacterial infection. In this study, an electrospun polylactide (PLA) composite suitable for wound dressing, with enhanced antimicrobial and mechanical properties, was produced. The neat PLA, PLA/CH (10 wt.%), PLA/CH (5 wt.%), PLA/CHS (10 wt.%), PLA/CHS (5 wt.%), PLA/CH (2.5 wt.%) /CHS (2.5 wt.%) and PLA/CH (5 wt.%)/CHS (5 wt.%), were electrospun using 0.14 g/ml solution. Results show that crystallinity (67.6%) of neat PLA declined by 3.8% on the addition of 2.5 wt.% chitin/chitosan with improved hydrophilicity of the composite. The tensile strength of neat PLA (0.3 MPa) increased (0.6 MPa) with 2.5 wt.% chitin/chitosan addition. The slight increase in the glass transition temperature from 75°C for neat PLA to 78°C of the composite fibre, showed improved ductility. The fibres showed little beads, hence suitable for wound dressing. The electrospun mats have good water absorption capacity and strong resistance against Staphylococcus aureus. Good performance was attained at 5 wt.% of chitin, chitosan and hybrid reinforcements. Therefore, a PLA/chitin/chitosan composite is recommended as a wound dressing material.

Słowa kluczowe

EN

chitin; chitosan; hydrophilicity; polylactide acid; skin; wound; staphylococcus-Auerus

• Wydawca: AGH University of Science and Technology Press
• Czasopismo: Journal of Casting & Materials Engineering
• Rocznik: 2022
• Tom: Vol. 6, no. 1
• Strony: 22--32
• Opis fizyczny: Bibliogr. 43 poz., fot., wykr.

Twórcy

autor

Odili Cletus Chiosa

• University of Lagos, Faculty of Engineering, Department of Metallurgical and Materials Engineering, Nigeria

• https://orcid.org/0000-0002-9697-1463

autor

Sekunowo Olatunde Israel

• University of Lagos, Faculty of Engineering, Department of Metallurgical and Materials Engineering, Nigeria

• https://orcid.org/0000-0002-9918-6874+

autor

Ilomuanya Margaret Okonawan

• University of Lagos, Faculty of Pharmacy, Department of Pharmaceutics and Pharmaceutical Technology, Nigeria

• https://orcid.org/0000-0001-8819-1937

autor

Gbenebor Oluwashina Philips

• University of Lagos, Faculty of Engineering, Department of Metallurgical and Materials Engineering, Nigeria

• https://orcid.org/0000-0003-1693-4601

autor

Adeosun Samson Oluropo

• University of Lagos, Faculty of Engineering, Department of Metallurgical and Materials Engineering, Nigeria
• Durban University of Technology, Durban South Africa, Industrial Engineering Department

• https://orcid.org/0000-0001-9847-7592

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Uwagi

PL

Opracowanie rekordu ze środków MEiN, umowa nr SONP/SP/546092/2022 w ramach programu „Społeczna odpowiedzialność nauki” - moduł: Popularyzacja nauki i promocja sportu (2022-2023)