1,4-Dioksan

• Autorzy: Starek A.

Warianty tytułu

EN

1,4-Dioxane

• Języki publikacji: PL

Abstrakty

PL

1,4-Dioksan jest łatwo palną cieczą, stosowaną w przemyśle głównie jako rozpuszczalnik farb, lakierów, tworzyw sztucznych i pochodnych celulozy. Obecnie narażenie na ten związek jest raczej niewielkie. Ostra toksyczność 1,4-dioksanu jest mała. W warunkach narażenia powtarzanego, zwłaszcza przewlekłego, 1,4-dioksan wywiera toksyczne działanie układowe, uszkadzając wątrobę i nerki. Działanie takie wywołuje 1,4-dioksan o dużych stężeniach lub dawkach. Stwierdzono, że związek ten działa drażniąco na błony śluzowe oczu, nosa i gardła. 1,4-Dioksan nie działa mutagennie i genotoksycznie. U gryzoni wywiera działanie kancerogenne, indukując głównie raka błony śluzowej nosa i wątroby. Dane na temat wpływu tego związku na ontogenetyczny rozwój organizmu są nieliczne. Za podstawę wartości NDS 1,4-dioksanu przyjęto jego działanie drażniące u ludzi oraz toksyczne działanie układowe u szczurów w 2-letnim doświadczeniu inhalacyjnym. Z wartości LOAEL (180 mg/m3), uzyskanej na podstawie wyników badań na ochotnikach, a także dwóch współczynników niepewności, obliczono wartość NDS wynoszącą 45 mg/m3, a wychodząc z wartości NOAEL dla efektów układowych (400 mg/m3) i dwóch współczynników niepewności, obliczono wartość NDS równą 100 mg/m3. Zaproponowano wartość NDS 1,4-dioksanu na poziomie 50 mg/m3, która będzie chroniła pracowników zarówno przed działaniem drażniącym, jak i przed działaniem układowym związku. Nie znaleziono podstaw merytorycznych do zaproponowania wartości najwyższego dopuszczalnego stężenia chwilowego (NDSCh) i dopuszczalnego stężenia w materiale biologicznym (DSB) 1,4-dioksanu.

EN

1,4-Dioxane is a highly flammable liquid with etheric odour. This compound is used, among other, as a solvent in the production of lacquers, varnishes, cleaning and detergent preparations, adhesives, cosmetics, extraction media for animal and vegetable oil. At present exposure to this chemical is rather low. Acute toxicity of 1,4-dioxane for laboratory animals is low. The liver, kidneys, mucous membrane of respiratory tract and eyes are critical organs in animals repeatedly exposed to 1,4-dioxane. No mutagenic, genotoxic, and teratogenic effects have been found in relevant experimental studies. Liver and nasal adenomas and carcinomas were seen in rats and mice after oral administration of 1,4- dioxane. The MAC (TWA) value was calculated on the basis of the LOAEL value (180 mg/m3) for irritation of the eye in volunteers and of the NOAEL value (400 mg/m3) for systemic toxic effects in rats.The MAC (TWA) value at the level of 50 mg/m3 was proposed. There is no evidence justifying a proposal of a MAC-STEL value.

Słowa kluczowe

PL

1,4-dioksan; rozpuszczalnik organiczny

EN

1,4-dioxane; organic solvent

• Wydawca: Centralny Instytut Ochrony Pracy - Państwowy Instytut Badawczy
• Czasopismo: Podstawy i Metody Oceny Środowiska Pracy
• Rocznik: 2006
• Tom: Nr 2 (48)
• Strony: 81--99
• Opis fizyczny: Bibliogr. 53 poz., rys., tab.

Twórcy

autor

Starek A.

• Collegium Medicum Uniwersytetu Jagiellońskiego 30-688 Kraków ul. Medyczna 9

Bibliografia

• 1.ACGIH, American Conference of Governmental Industrial Hygienists (2001) 1,4-1,4-dioksane. Baza danych CD-ROM, 1-5.
• 2.ACGIH, American Conference of Governmental Industrial Hygienists (2003) Guide to Occupational Exposure Values 53.
• 3.Argus M.F., Arcos J.C., Hoch-Ligeti C. (1965) Studies on the carcinogenic activity of proteindenaturing agents: hepatocarcinogenicity of dioxane. J. Natl. Cancer Inst. 35, 949-954.
• 4.Barber H. (1996) Hemorrhagic nephritis and necrosis of the liver from dioxan poisoning. Guys Hosp. Rep., 1934, 84, 267-280 (cyt. za DeRosa i in. 1996).
• 5.Braun W.H., Young J.D. (1977) Identification of β-hydroxyethoxyacetic acid as the major urinary metabolite of 1,4-dioxane in the rat. Toxicol. Appl. Pharmacol. 39, 33-38.
• 6.Buffler P.A. i in. (1978) Mortality follow-up of workers exposed to 1,4-dioxane. J. Occup. Med. 20, 255-259.
• 7.DeRosa C.T. i in. (1996) Health evaluation of 1,4-dioxane. Toxicol. Ind. Health 12, 1-43.
• 8.DFG, Deutsche Forschungsgemeinschaft (2003) List of MAK and BAT Values 2003. Wiley-VCH, 57.
• 9.Fisher J. i in. (1997) Lactational transfer of volatile chemicals in breast milk. Am. Ind. Hyg. Assoc. J. 58, 425-431.
• 10.Fregert S. (1974) Allergic contact dermatitis from dioxane in a solvent for cleaning metal parts. Cont. Dermat. Newslett. 15, 438.
• 11.Galloway S.M. i in. (1987) Chromosome aberrations and sister chromatid exchanges in Chinese hamster ovary cells: evaluations of 108 chemicals. Environ. Mol. Mutag. 10 (suppl. 10), 1-175.
• 12.Gingell R. i in. (1994) Glycol ethers and other selected glycol derivatives. W: Patty’s Industrial hygiene and toxicology. 4th ed., T. II, cz. D, Toxicology, 2821-2830.(Red.) G.D. Clayton, F.E.Clayton, NY, Willey Inc.
• 13.Giavini E., Vismara C., Broccia M.L. (1985) Teratogenesis study of dioxane in rats. Toxicol. Lett. 26, 85-88.
• 14.Goldsworthy T.L. i in. (1991) Examination of potential mechanisms of carcinogenicity of 1,4-dioxane in rat nasal epithelial cells and hepatocytes. Arch. Toxicol. 65, 1-9.
• 15.Haworth S. i in. (1983) Salmonella mutagenicity test results for 250 chemicals. Environ. Mutag. 5 (suppl. 1), 3-142.
• 16.Hoch-Ligeti C., Argus M.F., Arcos J.C. (1970) Induction of carcinomas in the nasal cavity of rats by dioxane. Br. J. Canc. 24, 164-167.
• 17.IARC, International Agency for Reserch on Cancer (1987) 1,4-Dioxane (Group 2B). W: IARC monographs on the evaluation of the carcinogenic risk to humans. Overall evaluation of carcinogenicity: an updating of IARC monographs. T. 1 to 42, supplement 7. Lyons, World Health Organization, 201.
• 18.Johnstone R.J. (1959) Death due to dioxane? Arch. Ind. Health 20, 445-447.
• 19.Kociba R.J. i in. (1974) 1,4-Dioxane. I. Results of a 2-year ingestion study in rats. Toxicol. Appl. Pharmacol. 1974, 30, 275-286.
• 20.Kurl R.N. i in. (1981) Effects of dioxane on RNA synthesis in the rat liver. Arch. Toxicol. 49, 29-33.
• 21.Laug E. i in. (1996) The toxicology of some glycols and derivatives. J. Ind. Hyg. Toxicol. 1939, 21, 173-201 (cyt. za DeRosa i in. 1996).
• 22.Lundberg I.M. i in. (1987) Three industrial solvents investigated for tumor promoting activity in tha rat liver. Cancer Lett. 36, 29-33.
• 23.Marzulli F.N., Anjo D.M., Maibach H.I. (1981) In vivo skin penetration studies of 2,4-toluenediamine, 2,4-diaminoanisole, 2-nitro-p-phenylenediamine, p-dioxane and N-nitrosodiethanolamine in cosmetics. Food Cosmet. Toxicol. 19, 743-747.
• 24.McFee A.F. i in. (1994) Results of mouse bone marrow micronucleus studies on 1,4-dioxane. Mutat. Res. 322, 145-148.
• 25.McGregor D.B. i in. (1991) Responses of L5178Y mouse lymphomas cell forward mutation assay. V. 27 coded chemicals. Environ. Mol. Mutagen. 17, 196-219.
• 26.Merck (2001) The Merck index. 13th ed. NJ, Whitehouse Station, Merck & CO, INC, 581.
• 27.Mirkova E.T. (1994) Activity of the rodent carcinogen 1,4-dioxane in the mouse bone marrow micronucleus assay. Mutat. Res. 322, 141-150.
• 28.Miyagawa M. i in. (1999) Repeat-assessment of 1,4-dioxane in a rat-hepatocyte replicative DNA synthesis (RDS) test: evidence for stimulus of hepatocyte proliferation. Exp. Toxic. Pathol. 51, 555-558.
• 29.Morita T., Hayashi M. (1998) 1,4-Dioxane is not mutagenic in five in vitro assays and mouse peripheral blood micronucleus assay, but is in mouse liver micronucleus assay. Environ. Mol. Mutagen. 32, 269-280.
• 30.Mungikar A.M., Sitaram S.P. (1978) Induction of the hepatic microsomal mixed function oxidase system in mice by p-dioxane. Environ. Contam. Toxicol. 20, 797-804.
• 31.NCI, National Cancer Institute U.S. (1978) Bioassay of 1,4-dioxane for possible carcinogenicity. Carcinogenesis (CAS No. 123-91-1). NCI-CG-TR-80. U.S. Dept. of Health, Education, and Welfare, Public Health Service, U.S. National Institutes of Health, Bethesda, MD, (cyt. za DeRosa 1996).
• 32.Nelson N. (1951) Solvent toxicity with particular reference to certain octyl alcohols and dioxanes. Med. Bull. 11, 226-238 (cyt. za DeRosa 1996).
• 33.Neumann H.G. i in. (1998) Changes in the classification of carcinogenic chemicals in the work area. Int. Arch. Occup. Environ. Health 71, 566-574.
• 34.NIOSH, National Institute for Occupational Safety and Health U.S. (1997) Criteria for a recommended standard-occupational exposure to dioxane. W: NIOSH Criteria documents plus CD-ROM. DHHS (NIOSH) Pub. No. 97-106; NTIS Pub. No. PB-502-082. Springfield, U.S. National Technical Information Service, VA (cyt. za ACGIH 2001).
• 35.Pozzani U.C., Weil C.S., Carpenter C.P. (1959) The toxicological basis of threshold limit values – 5. The experimental inhalation of vapor mixtures by rats, with notes upon the relationship between single dose inhalation and single dose oral data. Am. Ind. Hyg. Assoc. J. 20, 364-369.
• 36.Reitz R.H. i in. (1990) Development of a physiologically based pharmacokinetic model for risk assessment with 1,4-dioxane. Toxicol. Appl. Pharmacol. 105, 37-54.
• 37.Sekizawa J. i in. (1994) A simple method for screening assessment of skin and eye irritation. J. Toxicol. Sci., 19, 26-35.
• 38.Silverman L., Schulte H.F., First M.W. (1996) Further studies on sensory response to certain industrial solvent vapor. J. Ind. Hyg. Toxicol., 1946, 28, 262-266 (cyt. za DeRosa i in. 1996).
• 39.Sonneck H.J. (1964) Kontaktekzem durch Dioxan in überwiegender lineärer Anordnung. Dermatol. Wschr. 191, 24-27.
• 40.Stott W.T., Quast J.F., Watanabe P.G. (1981) Differentiation of the mechanisms of oncogenicity of 1,4-dioxane and 1,3-hexachlorobutadiene in the rat. Toxicol. Appl. Pharmacol. 60, 287-300.
• 41.Thiess A.M., Tress E., Fleig I. (1976) Arbeitsmedizinische Untersuchungsergebnisse von Dioxanexponierten Mitarbeitern. Arbeitsmed. Sozialmed. Präventivmed. 11, 36-46.
• 42.Tinwell H., Ashby J. (1994) Activity of 1,4-dioxane in mouse bone marrow micronucleus assays. Mutat. Res. 322, 148-150.
• 43.Torkelson T.R. i in. (1974) 1,4-Dioxane. II. Results of a 2-year inhalation study in rats. Toxicol. Appl. Pharmacol., 30, 287-298.
• 44.Woo Y. i in. (1977a) Metabolism in vivo of dioxane: identification of p-dioxane-2-one as the major urinary metabolite. Biochem. Pharmacol. 26, 1535-1538.
• 45.Woo Y., Argus M.F., Arcos J.C. (1977b) Tissue and subcellular distribution of 3H-dioxane in the rat and apparent lack of microsome-catalyzed covalent binding in the target tissue. Life Sci. 21, 1447- 1456.
• 46.Woo Y., Argus M.F., Arcos J.C. (1977c) Metabolism in vivo of dioxane: effect of inducers and inhibitors of hepatic mixed-functions oxidases. Biochem. Pharmacol. 26, 1539-1542.
• 47.Woo Y., Argus M.F., Arcos J.C. (1978) Effect of mixed-function oxidase modifiers on netabolism and toxicity of the oncogen dioxane. Cancer Res. 36, 1621-1625.
• 48.Yamazaki K. i in. (1994) Two-year toxicological and carcinogenesis studies of 1,4-dioxane in F344 rats and BDF1 mice – Drinking studies. Proceedings Second Asia-Pacific Symposium on Environmental and Occupational Health. Kobe, 22-24 July.
• 49.Yoon J.S. i in. (1985) Chemical mutagenesis testing in Drosophila. IV. Results of 45 coded compounds tested for the National Toxicology Program. Environ. Mutag. 7, 349-367.
• 50.Young J.D. i in. (1976) 1,4-Dioxane and β-hydroxyethoxyacetic acid excretion in urine of human exposed to dioxane vapor. Toxicol. Appl. Pharmacol. 38, 643-646.
• 51.Young J.D. i in. (1977) Pharmacokinetics of 1,4-dioxane in humans. J. Toxicol. Environ. Health 3, 507-520.
• 52.Young J.D., Braun W.H., Gehring P.J. (1978) Dose-dependent fate of 1,4-dioxane in rats. J. Toxicol. Environ. Health 4, 709-726.
• 53.Zimmermann F.K. i in. (1985) Acetone, methyl ethyl ketone, ethyl acetate, acetonitrile and other polar aprotic solvents are strong inducers of aneuploidy in Saccharomyces cerevisiae. Mutation. Res. 149, 339-351.