Classification of the Substances on the Basis of the Acute-Toxic-Class Method (ATC)

• Autorzy: Skowroń J. , Zapór L. , Miranowicz-Dzierżawska K.
• Języki publikacji: EN

Abstrakty

EN

The acute-toxic-class method (ATC) is an alternative to the classical LD50 test. Four substances were tested with an ATC testing procedure. The results were compared with LD50 data obtained from the literature. Great importance was attached to the observations of toxic signs following administration. The results of this study have shown that the ATC method allows allocation to toxicity classes in the same manner as on the basis of the classical LD50 tests. The ATC method uses fewer animals and yields the same information on toxic signs. Introducing the ATC method into the quality system allows estimating the acute oral toxicity of chemicals according to the Organisation for Economic Cooperation and Development (OECD; OECD, 1992, 1996).

Słowa kluczowe

EN

acute-toxic-class method; alternative LD50 test; animal welfare; classification

PL

toksyczność; substancje chemiczne; zwierzęta

• Wydawca: Taylor & Francis
• Czasopismo: International Journal of Occupational Safety and Ergonomics
• Rocznik: 1998
• Tom: Vol. 4, No. 1
• Strony: 107--115
• Opis fizyczny: Bibliogr. 2 poz., rys., tab.

Twórcy

autor

Skowroń J.

• Central Institute for Labour Protection, Poland

autor

Zapór L.

• Central Institute for Labour Protection, Poland

autor

Miranowicz-Dzierżawska K.

• Central Institute for Labour Protection, Poland

Bibliografia

• [1] Ballantyne, B. (1988). Toxicology and hazard evaluation of cyanide fumigation powders. Clinical Toxicology, 26(5 & 6), 325-335.
• [2] Bruce, R.D. (1985). An up-and-down procedure for acute toxicity testing. Fundamental and Applied Toxicology, 5, 151.