Materiały z bioaktywnymi związkami wspomagającymi syntezę kolagenu w skórze. Przegląd i zastosowanie

Niziołek, Karina; Słota, Dagmara; Iwaniec, Julia; Polanowski, Patryk

doi:10.15199/28.2025.3.1

Artykuł - szczegóły

Tytuł artykułu

Materiały z bioaktywnymi związkami wspomagającymi syntezę kolagenu w skórze. Przegląd i zastosowanie

Autorzy

Niziołek Karina , Słota Dagmara , Iwaniec Julia , Polanowski Patryk

Identyfikatory

DOI

10.15199/28.2025.3.1

Warianty tytułu

Materials with bioactive compounds that promote collagen synthesis in the skin. Review and application

Języki publikacji

Abstrakty

W przeglądzie omówiono najnowsze osiągnięcia w zakresie wykorzystania wybranych substancji, takich jak astaksantyna, siarczan chondroityny, kwas hialuronowy, kwas askorbinowy, kwas ferulowy oraz argirelina, w projektowaniu biomateriałów oraz produktów dermatologicznych i kosmetycznych. Związki te wykazują działanie przeciwutleniające, immunomodulujące, nawilżające i regeneracyjne, często wykorzystywane są jako składniki hydrożeli, nanonośników lub biotuszy do druku 3D. Przeanalizowano zarówno ich indywidualne właściwości, jak i potencjał synergicznego działania w kontekście poprawy struktury i funkcji skóry. Podkreślono także znaczenie odpowiedniego doboru matrycy biomateriału dla skutecznego uwalniania substancji czynnej oraz stymulacji produkcji kolagenu in vitro i in vivo. Wyniki te podkreślają potencjał terapeutyczny wielofunkcyjnych systemów bioaktywnych w dermatologii estetycznej i medycynie regeneracyjnej.

A review, with. 80 refs., on current advancements in the use of bioactive compounds, such as astaxanthin, chondroitin sulfate, hyaluronic acid, ascorbic acid, ferulic acid, and argireline, in materials designed to enhance collagen synthesis. These compounds exhibit antioxidant, antiinflammatory, moisturizing, and regenerative properties, and are increasingly integrated into hydrogels, nanocarriers, and 3D-printed scaffolds. Both, their individual and synergistic effects on fibroblast activation and collagen gene expression through signaling pathways such as TGF-β and MAP were discussed. Additionally, emphasis on the role of the biomaterial matrix in modulating compound release and supporting tissue-specific responses in vitro and in vivo was placed. These findings underline the therapeutic potential of multifunctional bioactive systems in aesthetic dermatology and regenerative medicine.

Słowa kluczowe

skóra produkcja kolagenu substancje aktywne astaksantyna siarczan chondroityny

skin collagen production active ingredients astaxanthin chondroitin sulfate

Wydawca

Wydawnictwo SIGMA-NOT

Czasopismo

Inżynieria Materiałowa

Rocznik

2025

Tom

Vol. 46, nr 3

Strony

5--12

Opis fizyczny

Bibliogr. 80 poz., fig.

Twórcy

autor

Niziołek Karina

Politechnika Krakowska im. Tadeusza Kościuszki, Wydział Inżynierii Materiałowej i Fizyki, Katedra Inżynierii Materiałowej

autor

Słota Dagmara

Politechnika Krakowska im. Tadeusza Kościuszki, Szkoła Doktorska PK, Wydział Inżynierii Materiałowej i Fizyki, Katedra Inżynierii Materiałowej
Politechnika Krakowska im. Tadeusza Kościuszki, Wydział Inżynierii Materiałowej i Fizyki, Katedra Inżynierii Materiałowej

autor

Iwaniec Julia

Politechnika Krakowska im. Tadeusza Kościuszki, Wydział Inżynierii Materiałowej i Fizyki, Katedra Inżynierii Materiałowej

autor

Polanowski Patryk

Politechnika Krakowska im. Tadeusza Kościuszki, Wydział Inżynierii Materiałowej i Fizyki, Katedra Inżynierii Materiałowej

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Uwagi

Opracowanie rekordu ze środków MNiSW, umowa nr POPUL/SP/0154/2024/02 w ramach programu "Społeczna odpowiedzialność nauki II" - moduł: Popularyzacja nauki (2025).

Typ dokumentu

Bibliografia

Identyfikator YADDA

bwmeta1.element.baztech-656b6e06-81f1-4370-af9c-daf9a4d7557b