Molecular Dynamics and structural comparison approach to understanding the role of knots in proteins

• Autorzy: Perlinska A. P. , Macnar J. M. , Sulkowska J. I.

Identyfikatory

DOI

10.17466/tq2016/20.4/h

• Języki publikacji: EN

Abstrakty

EN

The role of knots in proteins is still unclear. In this short review, we summarize the current knowledge about structural and dynamical differences between knotted and unknotted proteins. We show how the topological difference helps to distinguish the physical properties, characterize the biological activity or identify the biological function of knotted proteins. This knowledge can be used to correctly annotate protein family members and to identify new members.

Słowa kluczowe

EN

knotted proteins; methyltransferases; TrmD; Trm5; TrmJ; Trm7

• Wydawca: Politechnika Gdańska
• Czasopismo: TASK Quarterly : scientific bulletin of Academic Computer Centre in Gdansk
• Rocznik: 2016
• Tom: Vol. 20, No 4
• Strony: 373--382
• Opis fizyczny: Bibliogr. 40 poz., rys.

Twórcy

autor

Perlinska A. P.

• Centre of New Technologies, University of Warsaw, Banacha 2c, 02-097 Warsaw, Poland
• Inter-Faculty Individual Studies in Mathematics and Natural Sciences, University of Warsaw, Banacha 2c, 02-097 Warsaw, Poland

autor

Macnar J. M.

• Centre of New Technologies, University of Warsaw, Banacha 2c, 02-097 Warsaw, Poland
• Inter-Faculty Individual Studies in Mathematics and Natural Sciences, University of Warsaw, Banacha 2c, 02-097 Warsaw, Poland
• Faculty of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland

autor

Sulkowska J. I.

• Centre of New Technologies, University of Warsaw, Banacha 2c, 02-097 Warsaw, Poland
• Faculty of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland

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